SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d27'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 5d27 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN
(Homo
sapiens) 		4 / 8 ILE A 361
LEU A 298
LYS A 382
GLY A 276
 None
 0.84A 1os6A-5d27A:
undetectable		 1os6A-5d27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SEL_X_DXCX75_0
(CYTOCHROME C7)		 5d27 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN
(Homo
sapiens) 		4 / 8 ILE A 361
LEU A 298
LYS A 382
GLY A 276
 None
 0.81A 3selX-5d27A:
undetectable		 3selX-5d27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5d27 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN
(Homo
sapiens) 		4 / 6 ILE A 361
LEU A 298
LYS A 382
GLY A 276
 None
 0.77A 3sj1X-5d27A:
undetectable		 3sj1X-5d27A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 5d27 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 361
LEU A 298
LYS A 382
GLY A 276
 None
 0.84A 4hbfA-5d27A:
undetectable		 4hbfA-5d27A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 5d27 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN
(Homo
sapiens) 		4 / 5 HIS A 349
VAL A 355
GLY A 352
ALA A 346
 NI  A 501 (-3.5A)
None
None
None
 0.99A 5hwaA-5d27A:
undetectable		 5hwaA-5d27A:
20.46