SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 5d28 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
(Ovis
aries) 		4 / 4 THR B  71
LEU B  66
LEU B  59
GLN B  56
 None
 1.26A 1fbmA-5d28B:
undetectable		 1fbmA-5d28B:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		5 / 12 ALA A  87
LEU A  40
ALA A 212
LEU A 214
VAL A 210
 None
 1.02A 1sn5B-5d28A:
undetectable
1sn5D-5d28A:
undetectable		 1sn5B-5d28A:
17.72
1sn5D-5d28A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		5 / 12 LEU A  40
ALA A 212
LEU A 214
VAL A 210
ALA A  87
 None
 1.02A 1sn5B-5d28A:
undetectable
1sn5D-5d28A:
undetectable		 1sn5B-5d28A:
17.72
1sn5D-5d28A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 5d28 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
(Ovis
aries) 		4 / 4 LEU B  73
SER B  29
LEU B 114
LEU B 110
 None
 1.09A 1yajA-5d28B:
undetectable		 1yajA-5d28B:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 6 ARG A  26
GLY A  24
ALA A 220
GLU A  25
 None
 1.05A 4g0uA-5d28A:
undetectable		 4g0uA-5d28A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 8 MET A  44
LEU A  40
ALA A 212
LEU A 214
 None
 0.94A 4ik6B-5d28A:
undetectable		 4ik6B-5d28A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 6 LEU A 214
ALA A  38
LEU A  40
SER A 115
 None
 1.05A 4ikiB-5d28A:
undetectable		 4ikiB-5d28A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 6 ARG A  96
ASP A 117
ASP A 114
ARG A  39
 None
 1.36A 4kcnA-5d28A:
undetectable		 4kcnA-5d28A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 6 ARG A  96
ASP A 117
ASP A 114
ARG A  39
 None
 1.39A 4kcnB-5d28A:
undetectable		 4kcnB-5d28A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		5 / 10 ARG A 184
PRO A 185
ALA A 192
PHE A 229
LEU A 140
 None
 1.45A 4la0A-5d28A:
undetectable		 4la0A-5d28A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 8 MET A 176
LEU A 179
LEU A 144
LEU A 137
 None
 1.22A 5dxeA-5d28A:
undetectable		 5dxeA-5d28A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_A_IPHA101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 4 CYH A  90
LEU A 149
LEU A  40
ALA A 212
 None
 1.13A 5hpuA-5d28A:
undetectable
5hpuB-5d28A:
undetectable		 5hpuA-5d28A:
6.48
5hpuB-5d28A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
(Orf
virus;
Ovis
aries) 		3 / 3 TYR A 228
TYR A 112
SER B  24
 None
 0.98A 5iktB-5d28A:
undetectable		 5iktB-5d28A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 5d28 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR
(Ovis
aries) 		5 / 10 PRO B 118
ALA B  18
GLY B  75
THR B  74
ALA B  22
 None
 1.17A 5vyhA-5d28B:
undetectable		 5vyhA-5d28B:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5d28 GM-CSF/IL-2
INHIBITION FACTOR
(Orf
virus) 		4 / 8 MET A 176
LEU A 179
LEU A 144
LEU A 137
 None
 1.22A 6cbzA-5d28A:
undetectable		 6cbzA-5d28A:
18.97