SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 10 ALA A 209
VAL A 385
TYR A 188
LEU A 148
GLN A 147
 None
 1.37A 1aqbA-5d2eA:
undetectable		 1aqbA-5d2eA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 11 LEU A 475
ALA A 477
LEU A 481
ILE A 447
LEU A 285
 None
None
None
None
NAP  A 601 (-4.1A)
 1.15A 1g50A-5d2eA:
undetectable		 1g50A-5d2eA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 11 ALA A 209
VAL A 385
TYR A 188
LEU A 148
GLN A 147
 None
 1.34A 1kt6A-5d2eA:
undetectable		 1kt6A-5d2eA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 10 LEU A 475
ALA A 477
LEU A 481
ILE A 447
LEU A 285
 None
None
None
None
NAP  A 601 (-4.1A)
 1.21A 1pcgA-5d2eA:
undetectable		 1pcgA-5d2eA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 6 LEU A 475
GLY A 480
LEU A 285
ILE A 447
 None
None
NAP  A 601 (-4.1A)
None
 0.89A 1yajF-5d2eA:
2.2		 1yajF-5d2eA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 GLY A 280
ARG A 306
ASP A 333
SER A 335
ALA A 361
 NAP  A 601 (-3.5A)
NAP  A 601 (-3.7A)
NAP  A 601 (-3.6A)
GOL  A 602 (-3.6A)
NAP  A 601 (-3.5A)
 0.73A 2br4C-5d2eA:
2.6		 2br4C-5d2eA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 TYR A 292
VAL A 404
ALA A 477
ALA A 479
THR A  35
 None
 1.06A 2x2nC-5d2eA:
undetectable		 2x2nC-5d2eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 TYR A 346
VAL A 275
ALA A 332
THR A 313
LEU A 317
 PG4  A 603 (-3.4A)
None
PG4  A 603 (-3.9A)
None
None
 1.29A 2x2nC-5d2eA:
undetectable		 2x2nC-5d2eA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 TYR A 188
LEU A 148
SER A 151
SER A 410
ILE A 381
 None
 1.37A 3frqA-5d2eA:
undetectable		 3frqA-5d2eA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 GLY A 430
LEU A 148
SER A 151
SER A 410
VAL A 385
 None
 1.00A 3frqB-5d2eA:
undetectable		 3frqB-5d2eA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 10 VAL A 330
ALA A 332
ILE A 357
LEU A 354
ILE A 302
 PG4  A 603 (-4.6A)
PG4  A 603 (-3.9A)
None
None
None
 1.09A 3hbbA-5d2eA:
undetectable		 3hbbA-5d2eA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 7 MET A  40
LEU A 255
SER A 493
GLY A 426
 None
 1.11A 3hcnA-5d2eA:
2.6		 3hcnA-5d2eA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 5 PRO A 414
SER A 419
LEU A 409
SER A 408
 None
None
None
NAP  A 601 ( 4.0A)
 1.28A 3iluH-5d2eA:
undetectable		 3iluH-5d2eA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 5 ASN A 189
ALA A 190
TYR A 175
ALA A 209
 None
 1.32A 3twpD-5d2eA:
undetectable		 3twpD-5d2eA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 LEU A 114
LEU A 118
CYH A 168
ILE A 128
ILE A  85
 None
 1.12A 4a7aB-5d2eA:
undetectable		 4a7aB-5d2eA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 7 VAL A 364
SER A 408
GLN A 418
TYR A 421
 None
NAP  A 601 ( 4.0A)
None
NAP  A 601 (-4.4A)
 0.55A 4hxyB-5d2eA:
35.0		 4hxyB-5d2eA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 5 ILE A 129
PHE A 423
CYH A 207
HIS A 127
 None
 1.14A 4rzvA-5d2eA:
undetectable		 4rzvA-5d2eA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 7 PHE A 289
GLY A 480
THR A  35
LEU A  37
 None
 0.89A 4zdzA-5d2eA:
undetectable		 4zdzA-5d2eA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 LEU A 132
PHE A 159
ILE A  60
PHE A  63
TYR A 111
 None
 1.36A 5dlvA-5d2eA:
undetectable		 5dlvA-5d2eA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5d2e MLNE
(Bacillus
velezensis) 		3 / 3 ALA A 319
ASN A 322
LEU A 323
 None
 0.28A 5i1nB-5d2eA:
undetectable		 5i1nB-5d2eA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 4 LEU A 391
ARG A 440
ILE A 357
PHE A 403
 None
 1.31A 5kirB-5d2eA:
undetectable		 5kirB-5d2eA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5d2e MLNE
(Bacillus
velezensis) 		4 / 6 LYS A 208
PHE A 205
PHE A 159
LEU A 155
 None
 1.20A 5x19P-5d2eA:
undetectable		 5x19P-5d2eA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 GLY A 356
PRO A 441
GLY A 442
LEU A 277
ASP A 401
 None
 1.32A 5ynmA-5d2eA:
4.3		 5ynmA-5d2eA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5d2e MLNE
(Bacillus
velezensis) 		3 / 3 SER A 446
SER A 407
ALA A 190
 None
 0.58A 6dwnC-5d2eA:
undetectable		 6dwnC-5d2eA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 5d2e MLNE
(Bacillus
velezensis) 		5 / 12 GLY A 387
ILE A 357
GLU A 339
LEU A 343
ILE A 344
 None
None
PG4  A 603 (-3.9A)
PG4  A 603 ( 4.5A)
None
 1.06A 6ectA-5d2eA:
3.2		 6ectA-5d2eA:
21.20