SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		3 / 3 TRP A 499
VAL A 441
TRP A 428
 None
 1.26A 1c4dC-5d39A:
undetectable
1c4dD-5d39A:
undetectable		 1c4dC-5d39A:
3.30
1c4dD-5d39A:
3.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 5 THR A 187
GLU A 185
THR A 253
LEU A 261
 None
 1.37A 1d4fC-5d39A:
undetectable		 1d4fC-5d39A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 8 LEU A 507
LEU A 477
VAL A 521
GLY A 520
 None
 1.02A 2po5A-5d39A:
undetectable		 2po5A-5d39A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		3 / 3 GLU A 185
GLY A 188
THR A 187
 None
 0.55A 3iazA-5d39A:
undetectable		 3iazA-5d39A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 5 PHE A 518
GLY A 468
THR A 465
VAL A 463
 None
 1.04A 3wrkD-5d39A:
undetectable		 3wrkD-5d39A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 8 ARG A 260
GLU A 191
GLU A 189
ARG A 140
 None
 1.12A 4bqfB-5d39A:
undetectable		 4bqfB-5d39A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 6 LEU A 302
GLU A 348
VAL A 311
ALA A 390
 None
 1.05A 4nkvC-5d39A:
undetectable		 4nkvC-5d39A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 8 ILE A 577
LEU A 561
VAL A 547
LEU A 551
 None
 0.80A 4r38A-5d39A:
undetectable		 4r38A-5d39A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		5 / 12 ILE A 568
PHE A 514
GLY A 511
ILE A 506
LEU A 455
 None
 1.03A 5e72A-5d39A:
undetectable		 5e72A-5d39A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 6 ARG A 140
LEU A 137
ARG A 135
ARG A 136
 None
 1.10A 5l6eA-5d39A:
undetectable
5l6eB-5d39A:
undetectable		 5l6eA-5d39A:
19.38
5l6eB-5d39A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		4 / 6 THR A 267
ARG A 266
ASP A 262
GLY A 259
 None
 0.89A 5mraA-5d39A:
undetectable
5mraB-5d39A:
undetectable		 5mraA-5d39A:
16.14
5mraB-5d39A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		5 / 10 SER A 531
LEU A 615
ILE A 606
SER A 627
GLY A 603
 None
 1.34A 6dlzA-5d39A:
undetectable
6dlzD-5d39A:
2.3		 6dlzA-5d39A:
11.60
6dlzD-5d39A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		5 / 10 ILE A 606
SER A 627
GLY A 603
SER A 531
LEU A 615
 None
 1.34A 6dlzB-5d39A:
2.3
6dlzC-5d39A:
undetectable		 6dlzB-5d39A:
11.60
6dlzC-5d39A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		5 / 10 SER A 531
LEU A 615
ILE A 606
SER A 627
GLY A 603
 None
 1.26A 6dm0B-5d39A:
undetectable
6dm0C-5d39A:
undetectable		 6dm0B-5d39A:
11.60
6dm0C-5d39A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		5 / 10 SER A 531
LEU A 615
ILE A 606
SER A 627
GLY A 603
 None
 1.35A 6dm1A-5d39A:
undetectable
6dm1D-5d39A:
2.3		 6dm1A-5d39A:
11.60
6dm1D-5d39A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		5 / 10 ILE A 606
SER A 627
GLY A 603
SER A 531
LEU A 615
 None
 1.34A 6dm1B-5d39A:
2.3
6dm1C-5d39A:
undetectable		 6dm1B-5d39A:
11.60
6dm1C-5d39A:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5d39 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 6
(Homo
sapiens) 		3 / 3 LEU A 552
ASN A 588
LEU A 560
 None
 0.72A 6exiD-5d39A:
undetectable		 6exiD-5d39A:
9.70