SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d3o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO A 295
HIS A 311
GLY A 315
ASN A 336
GLY A 342
 None
 1.22A 1ffyA-5d3oA:
undetectable		 1ffyA-5d3oA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GHM_A_CEDA1_1
(BETA-LACTAMASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		6 / 12 SER A 291
LYS A 294
ASN A 340
LYS A 486
SER A 487
GLY A 488
 None
 0.42A 1ghmA-5d3oA:
4.9		 1ghmA-5d3oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 386
SER A 389
SER A 291
VAL A 293
TYR A 419
 None
 1.22A 1x70B-5d3oA:
undetectable		 1x70B-5d3oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TYR A 535
GLY A 469
PHE A 477
SER A 474
 None
 1.04A 2a3cB-5d3oA:
undetectable		 2a3cB-5d3oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 300
ILE A 350
PHE A 418
VAL A 376
VAL A 427
 None
 1.05A 2ygoA-5d3oA:
undetectable		 2ygoA-5d3oA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 289
ALA A 371
VAL A 496
VAL A 363
ILE A 425
 None
 1.02A 3czhB-5d3oA:
undetectable		 3czhB-5d3oA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 VAL A 489
SER A 291
ILE A 425
THR A 347
ASN A 340
 None
 1.13A 3ddyA-5d3oA:
undetectable		 3ddyA-5d3oA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PHE A 477
PHE A 473
ASN A 515
ILE A 493
GLY A 519
 None
 1.20A 3t3rD-5d3oA:
undetectable		 3t3rD-5d3oA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLU A 456
GLY A 306
SER A 454
 None
 0.67A 4b53B-5d3oA:
undetectable		 4b53B-5d3oA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU A 168
THR A 171
GLY A 275
ILE A 447
 None
 0.65A 4yjiA-5d3oA:
undetectable		 4yjiA-5d3oA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE A 224
PHE A 220
GLY A 275
LEU A 180
PHE A 164
 None
 1.19A 5fsaA-5d3oA:
undetectable		 5fsaA-5d3oA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLU A 145
LEU A 173
LEU A 215
LEU A 180
THR A 175
 None
 1.22A 5hnyB-5d3oA:
undetectable		 5hnyB-5d3oA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.03A 5n0oA-5d3oA:
undetectable		 5n0oA-5d3oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.03A 5n0oB-5d3oA:
undetectable		 5n0oB-5d3oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.01A 5n0rA-5d3oA:
undetectable		 5n0rA-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 0.99A 5n0sA-5d3oA:
undetectable		 5n0sA-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.00A 5n0tA-5d3oA:
undetectable		 5n0tA-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.00A 5n0tB-5d3oA:
undetectable		 5n0tB-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.02A 5n0wA-5d3oA:
undetectable		 5n0wA-5d3oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.03A 5n0wB-5d3oA:
undetectable		 5n0wB-5d3oA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.04A 5n0xA-5d3oA:
undetectable		 5n0xA-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.03A 5n0xB-5d3oA:
undetectable		 5n0xB-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 493
GLY A 519
HIS A 521
PHE A 473
ALA A 485
 None
 1.05A 5n4iA-5d3oA:
undetectable		 5n4iA-5d3oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 MET A 504
ASN A 441
VAL A 496
LEU A 494
 None
 1.38A 5xdhA-5d3oA:
undetectable
5xdhC-5d3oA:
undetectable		 5xdhA-5d3oA:
10.40
5xdhC-5d3oA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 549
ARG A 548
ASP A 546
 None
 0.77A 6d8pA-5d3oA:
undetectable		 6d8pA-5d3oA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 TYR A 419
VAL A 376
MET A 338
GLY A 342
 None
 1.43A 6hd4A-5d3oA:
undetectable		 6hd4A-5d3oA:
9.31