SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d43'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 5d43 CENTRIN-1
(Mus
musculus) 		5 / 9 ILE A 121
LEU A 126
GLU A 148
ALA A 149
VAL A 157
 None
None
None
None
CA  A1204 ( 4.9A)
 1.29A 1ctrA-5d43A:
12.4		 1ctrA-5d43A:
46.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CTR_A_TFPA153_1
(CALMODULIN)		 5d43 CENTRIN-1
(Mus
musculus) 		5 / 9 ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
None
None
None
CA  A1204 ( 4.9A)
 0.67A 1ctrA-5d43A:
12.4		 1ctrA-5d43A:
46.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DTL_A_BEPA204_1
(CARDIAC TROPONIN C)		 5d43 CENTRIN-1
(Mus
musculus) 		5 / 11 PHE A 113
ILE A 121
LEU A 126
LEU A 133
MET A 145
 None
 0.84A 1dtlA-5d43A:
11.8		 1dtlA-5d43A:
37.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5d43 CENTRIN-1
(Mus
musculus) 		7 / 12 PHE A 113
ILE A 121
LEU A 126
MET A 145
ILE A 146
VAL A 157
MET A 166
 None
None
None
None
None
CA  A1204 ( 4.9A)
None
 0.84A 1lxfC-5d43A:
9.9		 1lxfC-5d43A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5d43 CENTRIN-1
(Mus
musculus) 		5 / 12 ILE A  48
LEU A  90
ALA A  91
PHE A  89
LEU A  60
 None
 0.88A 4psyA-5d43A:
undetectable		 4psyA-5d43A:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_A_TFPA203_1
(CALMODULIN)		 5d43 CENTRIN-1
(Mus
musculus) 		6 / 8 PHE A 113
ILE A 121
LEU A 126
MET A 145
ALA A 149
VAL A 157
 None
None
None
None
None
CA  A1204 ( 4.9A)
 0.36A 4rjdA-5d43A:
12.9		 4rjdA-5d43A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RJD_B_TFPB203_1
(CALMODULIN)		 5d43 CENTRIN-1
(Mus
musculus) 		5 / 7 PHE A 113
LEU A 126
MET A 145
ALA A 149
MET A 166
 None
 0.61A 4rjdB-5d43A:
12.7		 4rjdB-5d43A:
30.61