SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 4 GLY A 233
LEU A 231
GLY A 296
ARG A 232
 None
 1.21A 1j7kA-5d4kA:
undetectable		 1j7kA-5d4kA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 6 LEU A 217
ASP A 196
GLY A 318
ARG A 172
 None
 0.88A 1mt1G-5d4kA:
undetectable
1mt1J-5d4kA:
undetectable		 1mt1G-5d4kA:
6.38
1mt1J-5d4kA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 GLN A 314
SER A 319
LEU A 315
PRO A 222
ILE A 321
 None
 1.46A 1ynnC-5d4kA:
undetectable		 1ynnC-5d4kA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		3 / 3 ARG A  43
GLY A 242
PRO A 243
 None
 0.49A 2hreD-5d4kA:
undetectable		 2hreD-5d4kA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		3 / 3 PRO A  26
GLY A  73
TYR A  24
 None
 0.75A 2vouA-5d4kA:
undetectable		 2vouA-5d4kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		3 / 3 VAL A 540
TRP A 480
TRP A 525
 None
 1.36A 2xdcC-5d4kA:
undetectable
2xdcD-5d4kA:
undetectable		 2xdcC-5d4kA:
3.55
2xdcD-5d4kA:
3.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 8 GLN A 255
GLN A 314
ASP A 262
SER A 256
 None
 1.14A 2xz5C-5d4kA:
undetectable
2xz5D-5d4kA:
undetectable		 2xz5C-5d4kA:
18.67
2xz5D-5d4kA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		5 / 11 ASP A 312
SER A 311
PHE A 251
LEU A 126
SER A 319
 None
 1.38A 3ko0Q-5d4kA:
undetectable
3ko0R-5d4kA:
undetectable
3ko0S-5d4kA:
undetectable
3ko0T-5d4kA:
undetectable		 3ko0Q-5d4kA:
8.94
3ko0R-5d4kA:
8.94
3ko0S-5d4kA:
8.94
3ko0T-5d4kA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 GLY A  45
VAL A 124
ASP A 125
ALA A 240
SER A 289
 None
 1.02A 3sudD-5d4kA:
undetectable		 3sudD-5d4kA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 6 ARG A 144
GLN A 203
PHE A 185
LEU A 175
 None
 1.37A 3tgvB-5d4kA:
undetectable		 3tgvB-5d4kA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 5 PHE A 275
ARG A 271
PRO A 273
ALA A 274
 None
 1.37A 3vm4A-5d4kA:
undetectable		 3vm4A-5d4kA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 8 PHE A 406
SER A 396
VAL A 381
TRP A 366
 None
 0.98A 4d32A-5d4kA:
undetectable
4d32B-5d4kA:
undetectable		 4d32A-5d4kA:
20.82
4d32B-5d4kA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 GLN A 314
SER A 319
LEU A 315
PRO A 222
ILE A 321
 None
 1.43A 4kmuC-5d4kA:
undetectable		 4kmuC-5d4kA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 SER A 319
LEU A 315
PRO A 222
ILE A 321
ARG A  43
 None
 1.45A 4kmuC-5d4kA:
undetectable		 4kmuC-5d4kA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 312
LYS A 250
LEU A 241
 None
 0.94A 4ptjA-5d4kA:
undetectable		 4ptjA-5d4kA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 5 ARG A 416
THR A 414
ASP A 417
TYR A 391
 None
 1.08A 4qwpB-5d4kA:
undetectable		 4qwpB-5d4kA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 6 PHE A  69
PRO A  70
GLY A  73
THR A  74
 NAG  A 602 ( 2.9A)
None
None
NAG  A 602 ( 4.2A)
 0.94A 5x24A-5d4kA:
undetectable		 5x24A-5d4kA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 519
VAL A  56
GLN A 486
GLY A  62
ALA A  61
 None
None
NAG  A 605 (-2.5A)
None
None
 1.07A 5xxiA-5d4kA:
undetectable		 5xxiA-5d4kA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 5 GLN A 325
VAL A 227
TRP A 324
THR A 236
 None
 1.28A 6cduA-5d4kA:
undetectable
6cduB-5d4kA:
undetectable		 6cduA-5d4kA:
20.65
6cduB-5d4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_I_EY4I500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 5 GLN A 325
VAL A 227
TRP A 324
THR A 236
 None
 1.38A 6cduI-5d4kA:
undetectable
6cduJ-5d4kA:
undetectable		 6cduI-5d4kA:
20.65
6cduJ-5d4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR
(Homo
sapiens) 		4 / 7 VAL A 292
LEU A 241
LEU A 326
GLY A 308
 None
 0.80A 6eu9D-5d4kA:
undetectable		 6eu9D-5d4kA:
9.27