SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 TYR A 337
VAL A 294
ILE A 329
LEU A 355
 None
 0.97A 1j96A-5d4wA:
undetectable		 1j96A-5d4wA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 MET A 276
PHE A 351
MET A 301
ALA A 313
 None
 1.34A 1linA-5d4wA:
undetectable		 1linA-5d4wA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 GLN A 690
PHE A 661
PHE A 705
GLY A 677
 None
 1.20A 2qmzA-5d4wA:
undetectable
2qmzB-5d4wA:
undetectable		 2qmzA-5d4wA:
12.75
2qmzB-5d4wA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 823
ASP A 820
ASP A 822
 None
 0.92A 3jb2A-5d4wA:
2.2		 3jb2A-5d4wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 823
ASP A 820
ASP A 822
 None
 0.85A 3jb3A-5d4wA:
undetectable		 3jb3A-5d4wA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 4 PHE A 700
TYR A 398
VAL A 744
LEU A 703
 None
 1.32A 3keeD-5d4wA:
undetectable		 3keeD-5d4wA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ILE A 659
PHE A 705
ASP A 662
GLU A 665
 None
 1.05A 3kp6A-5d4wA:
undetectable
3kp6B-5d4wA:
undetectable		 3kp6A-5d4wA:
9.99
3kp6B-5d4wA:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 VAL A 561
ARG A 423
VAL A 421
GLN A 565
 None
 0.98A 3remA-5d4wA:
undetectable		 3remA-5d4wA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 8 VAL A 561
ARG A 423
VAL A 421
GLN A 565
 None
 0.99A 3remB-5d4wA:
undetectable		 3remB-5d4wA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 11 GLN A 690
PHE A 661
ILE A 659
PHE A 705
GLY A 677
 None
 1.32A 4fglA-5d4wA:
undetectable
4fglB-5d4wA:
undetectable		 4fglA-5d4wA:
12.02
4fglB-5d4wA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 716
LEU A 691
PHE A 705
ALA A 711
MET A 663
 None
 1.32A 4hwkC-5d4wA:
undetectable		 4hwkC-5d4wA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 255
LEU A 292
LEU A 211
ILE A 240
VAL A 245
 None
 1.14A 4ok1A-5d4wA:
undetectable		 4ok1A-5d4wA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 6 ARG A 403
ASP A 406
GLY A 228
GLU A 234
 None
ADP  A1001 (-4.1A)
ADP  A1001 (-3.3A)
None
 1.05A 5cdqA-5d4wA:
2.8
5cdqC-5d4wA:
2.8
5cdqD-5d4wA:
undetectable		 5cdqA-5d4wA:
20.37
5cdqC-5d4wA:
20.37
5cdqD-5d4wA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 702
PHE A 650
ILE A 614
ILE A 599
ALA A 595
 None
 1.05A 5e72A-5d4wA:
undetectable		 5e72A-5d4wA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 423
HIS A 379
ARG A 420
 None
 1.14A 5iaoC-5d4wA:
undetectable		 5iaoC-5d4wA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		4 / 7 GLY A 270
GLU A 273
LYS A 311
ALA A 313
 None
 0.91A 5mvsA-5d4wA:
undetectable		 5mvsA-5d4wA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5d4w PUTATIVE HEAT SHOCK
PROTEIN
(Chaetomium
thermophilum) 		3 / 3 GLY A 689
THR A 692
GLU A 693
 None
 0.60A 6b58A-5d4wA:
2.5		 6b58A-5d4wA:
20.09