SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5d5p HCGB
(Methanococcus
maripaludis) 		5 / 10 LEU A 112
GLY A 110
GLY A 125
LEU A 114
ALA A  82
 None
 0.99A 2v3kA-5d5pA:
undetectable		 2v3kA-5d5pA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5d5p HCGB
(Methanococcus
maripaludis) 		5 / 11 ILE A  65
ILE A  60
LEU A 150
ILE A 115
THR A  44
 None
 0.89A 3clbA-5d5pA:
undetectable		 3clbA-5d5pA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5d5p HCGB
(Methanococcus
maripaludis) 		5 / 12 ILE A  65
ILE A  60
LEU A 150
ILE A 115
THR A  44
 None
 0.82A 3clbC-5d5pA:
undetectable		 3clbC-5d5pA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5d5p HCGB
(Methanococcus
maripaludis) 		5 / 11 ILE A  65
ILE A  60
LEU A 150
ILE A 115
THR A  44
 None
 0.80A 3hbbC-5d5pA:
undetectable		 3hbbC-5d5pA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5d5p HCGB
(Methanococcus
maripaludis) 		4 / 5 ARG A 101
SER A 111
SER A 128
SER A 126
 None
 1.39A 5hswA-5d5pA:
undetectable		 5hswA-5d5pA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5d5p HCGB
(Methanococcus
maripaludis) 		4 / 6 THR A 124
ARG A 152
ILE A  27
GLU A  26
 None
 0.96A 5uigA-5d5pA:
undetectable		 5uigA-5d5pA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5d5p HCGB
(Methanococcus
maripaludis) 		5 / 10 ILE A  30
ILE A  34
LEU A  97
ILE A   7
ASN A   5
 None
 1.39A 5vkqA-5d5pA:
undetectable
5vkqD-5d5pA:
undetectable		 5vkqA-5d5pA:
7.45
5vkqD-5d5pA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5d5p HCGB
(Methanococcus
maripaludis) 		5 / 10 ILE A   7
ASN A   5
ILE A  30
ILE A  34
LEU A  97
 None
 1.37A 5vkqA-5d5pA:
undetectable
5vkqB-5d5pA:
undetectable		 5vkqA-5d5pA:
7.45
5vkqB-5d5pA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5d5p HCGB
(Methanococcus
maripaludis) 		5 / 10 ILE A   7
ASN A   5
ILE A  30
ILE A  34
LEU A  97
 None
 1.38A 5vkqC-5d5pA:
undetectable
5vkqD-5d5pA:
undetectable		 5vkqC-5d5pA:
7.45
5vkqD-5d5pA:
7.45