SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d68'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 514
TYR A 460
ILE A 664
GLU A 534
LEU A 626
 None
 1.24A 1mrqA-5d68A:
undetectable		 1mrqA-5d68A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 683
LEU A 669
VAL A 660
PHE A 697
HIS A 668
 None
 1.27A 1q23A-5d68A:
undetectable
1q23B-5d68A:
undetectable		 1q23A-5d68A:
19.45
1q23B-5d68A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		3 / 3 TRP A 322
PHE A 361
TRP A 330
 None
 1.35A 1r15C-5d68A:
undetectable		 1r15C-5d68A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		3 / 3 TRP A 322
PHE A 361
TRP A 330
 None
 1.34A 1r15F-5d68A:
undetectable		 1r15F-5d68A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		3 / 3 TRP A 322
PHE A 361
TRP A 330
 None
 1.34A 1r15G-5d68A:
undetectable		 1r15G-5d68A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		3 / 3 TRP A 322
PHE A 361
TRP A 330
 None
 1.34A 1r15H-5d68A:
undetectable		 1r15H-5d68A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 530
LEU A 626
ALA A 535
GLU A 534
 None
 1.05A 1xvaA-5d68A:
undetectable
1xvaB-5d68A:
undetectable		 1xvaA-5d68A:
17.99
1xvaB-5d68A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 708
TYR A 683
VAL A 660
LEU A 669
 None
 0.80A 2w98B-5d68A:
undetectable		 2w98B-5d68A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 621
GLN A 622
PHE A 625
LEU A 608
 None
 1.01A 3ag1C-5d68A:
undetectable
3ag1J-5d68A:
undetectable		 3ag1C-5d68A:
19.57
3ag1J-5d68A:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		5 / 12 THR A 380
GLY A 439
ASP A 381
ILE A 384
SER A 357
 None
 1.32A 4pooB-5d68A:
undetectable		 4pooB-5d68A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 411
ALA A 407
VAL A 371
GLY A 364
GLY A 366
 None
 0.98A 4rn6B-5d68A:
undetectable		 4rn6B-5d68A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 340
GLU A 335
LEU A 374
HIS A 326
 None
 1.35A 4xi3B-5d68A:
undetectable		 4xi3B-5d68A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 374
ASP A 381
LEU A 375
LEU A 411
ALA A 414
 None
 1.01A 5dqfA-5d68A:
undetectable		 5dqfA-5d68A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_C_IPHC101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 5 ILE A 395
CYH A 396
LEU A 411
HIS A 360
 None
 1.34A 5hrqC-5d68A:
undetectable
5hrqD-5d68A:
undetectable
5hrqL-5d68A:
undetectable		 5hrqC-5d68A:
4.76
5hrqD-5d68A:
7.69
5hrqL-5d68A:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 7 GLN A 689
GLY A 691
ILE A 709
GLN A 643
 None
 1.06A 5vlmC-5d68A:
undetectable		 5vlmC-5d68A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN A 689
GLY A 691
ILE A 709
GLN A 643
 None
 0.95A 5vlmD-5d68A:
2.7		 5vlmD-5d68A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5d68 KREV INTERACTION
TRAPPED PROTEIN 1
(Homo
sapiens) 		4 / 4 ASP A 320
SER A 319
ASP A 318
HIS A 293
 None
 1.31A 5wyqB-5d68A:
1.8		 5wyqB-5d68A:
21.32