SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER A 347
GLY A 346
ARG A 233
 None
 0.63A 1t9wA-5d6bA:
undetectable		 1t9wA-5d6bA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU A 272
PRO A  91
ILE A  98
LEU A  99
 None
 1.01A 1ya4B-5d6bA:
undetectable		 1ya4B-5d6bA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  99
ALA A  95
ILE A 201
ALA A 103
PHE A 191
 None
 1.21A 2ejtA-5d6bA:
undetectable		 2ejtA-5d6bA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP A  65
THR A  72
GLY A  69
TYR A  68
 None
 0.95A 2f6dA-5d6bA:
undetectable		 2f6dA-5d6bA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 276
GLY A 282
ASN A 284
ALA A 308
LEU A 315
 None
 0.90A 3p2kA-5d6bA:
undetectable		 3p2kA-5d6bA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 GLN A  71
ASN A 178
ASN A 152
THR A 149
 None
 1.44A 4d1yA-5d6bA:
undetectable
4d1yB-5d6bA:
undetectable		 4d1yA-5d6bA:
17.20
4d1yB-5d6bA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL A 293
VAL A 297
LEU A 300
ASN A 150
 None
 0.94A 4e1gB-5d6bA:
1.0		 4e1gB-5d6bA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 123
VAL A 127
VAL A 106
GLN A 185
PHE A 289
 None
 1.34A 4zj8A-5d6bA:
4.2		 4zj8A-5d6bA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 170
VAL A 181
ILE A 116
GLY A 166
GLY A 167
 None
 0.94A 5koxA-5d6bA:
undetectable		 5koxA-5d6bA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 353
GLY A 348
LEU A 244
ASN A 441
LEU A 356
 None
 0.95A 5nfjB-5d6bA:
undetectable		 5nfjB-5d6bA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 353
GLY A 348
LEU A 244
ASN A 441
LEU A 356
 None
 0.95A 5nfjC-5d6bA:
undetectable		 5nfjC-5d6bA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS A 447
LEU A 448
ARG A 444
 None
 0.76A 5yw0A-5d6bA:
undetectable		 5yw0A-5d6bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET A  77
ASP A  55
ARG A  51
 None
 1.00A 5z6jA-5d6bA:
undetectable		 5z6jA-5d6bA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET A  77
ASP A  55
ARG A  51
 None
 1.15A 5z6kA-5d6bA:
undetectable		 5z6kA-5d6bA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 SER A 452
GLU A 355
ASP A 341
ASP A 238
 None
 1.28A 5zw4A-5d6bA:
undetectable		 5zw4A-5d6bA:
20.13