SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d6n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 264
VAL A 310
ALA A 338
ILE A 339
ILE A 317
 None
 1.01A 1epbA-5d6nA:
undetectable		 1epbA-5d6nA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 264
VAL A 310
ALA A 338
ILE A 339
ILE A 317
 None
 0.97A 1epbB-5d6nA:
undetectable		 1epbB-5d6nA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A  67
LEU A  70
ASP A 109
LEU A  83
VAL A 141
 None
 1.10A 1i9gA-5d6nA:
2.7		 1i9gA-5d6nA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASN A   5
PHE A  15
VAL A 209
 None
 0.70A 1kijA-5d6nA:
undetectable		 1kijA-5d6nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 ASP A 303
GLY A 330
ALA A 289
ILE A 264
 None
 0.64A 1n49A-5d6nA:
undetectable		 1n49A-5d6nA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 286
LEU A 267
VAL A 307
PHE A 334
ALA A 309
 None
 1.21A 1q23A-5d6nA:
undetectable
1q23B-5d6nA:
undetectable		 1q23A-5d6nA:
15.98
1q23B-5d6nA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 286
LEU A 267
VAL A 307
PHE A 334
ALA A 309
 None
 1.20A 1q23D-5d6nA:
undetectable
1q23E-5d6nA:
undetectable		 1q23D-5d6nA:
15.98
1q23E-5d6nA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 286
LEU A 267
VAL A 307
PHE A 334
ALA A 309
 None
 1.22A 1q23H-5d6nA:
undetectable
1q23I-5d6nA:
undetectable		 1q23H-5d6nA:
15.98
1q23I-5d6nA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 393
ILE A 339
ILE A 317
GLY A 313
ALA A 309
 None
 1.01A 1sh9B-5d6nA:
undetectable		 1sh9B-5d6nA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ALA A 472
VAL A 402
TRP A 421
 None
 0.92A 1tkqA-5d6nA:
undetectable		 1tkqA-5d6nA:
2.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLN A 185
ILE A 199
PHE A  95
LEU A  91
ILE A  82
 None
 0.98A 1xozA-5d6nA:
undetectable		 1xozA-5d6nA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A 133
THR A 134
THR A 135
ALA A 158
GLY A 140
 None
 1.22A 2f162-5d6nA:
undetectable		 2f162-5d6nA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 THR A 133
THR A 134
THR A 135
ALA A 158
GLY A 140
 None
 1.21A 2f16N-5d6nA:
undetectable		 2f16N-5d6nA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 ALA A 285
TRP A 226
LEU A 267
ALA A 289
 None
 1.17A 2jstA-5d6nA:
undetectable
2jstB-5d6nA:
undetectable		 2jstA-5d6nA:
8.57
2jstB-5d6nA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 471
ALA A 472
ASP A 414
VAL A 366
ILE A 376
 None
 1.03A 3d1zA-5d6nA:
undetectable		 3d1zA-5d6nA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ALA A 285
VAL A 310
ILE A 264
LEU A 304
PHE A 325
 None
 1.31A 3fl9H-5d6nA:
undetectable		 3fl9H-5d6nA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A 153
THR A  74
THR A 133
 None
 0.68A 3k2hB-5d6nA:
undetectable		 3k2hB-5d6nA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A  66
VAL A  80
ASN A  63
GLY A  96
 None
 1.14A 3kmoB-5d6nA:
undetectable		 3kmoB-5d6nA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 TYR A 343
LEU A 345
ASP A 232
SER A 188
 None
 1.06A 3lslA-5d6nA:
undetectable
3lslD-5d6nA:
undetectable		 3lslA-5d6nA:
19.09
3lslD-5d6nA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 SER A 188
TYR A 343
LEU A 345
ASP A 232
 None
 1.06A 3lslA-5d6nA:
undetectable
3lslD-5d6nA:
undetectable		 3lslA-5d6nA:
19.09
3lslD-5d6nA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 186
LEU A 184
GLY A 196
THR A 195
CYH A 126
 None
 1.18A 3okxA-5d6nA:
undetectable		 3okxA-5d6nA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 186
LEU A 184
GLY A 196
THR A 195
CYH A 126
 None
 1.19A 3okxB-5d6nA:
undetectable		 3okxB-5d6nA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 PHE A 145
THR A 147
ARG A 153
PRO A 149
 None
 1.07A 3tzfB-5d6nA:
undetectable		 3tzfB-5d6nA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A  80
GLY A  96
ALA A  97
ALA A 100
THR A  74
 None
 0.89A 3ucjA-5d6nA:
undetectable		 3ucjA-5d6nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A  80
GLY A  96
ALA A  97
ALA A 100
THR A  74
 None
 0.90A 3ucjB-5d6nA:
undetectable		 3ucjB-5d6nA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLU A 347
PHE A 442
ILE A 480
LEU A 478
GLY A 344
 None
 1.34A 4djfB-5d6nA:
undetectable		 4djfB-5d6nA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS A  14
PRO A  16
LYS A   9
 None
 1.28A 4duzL-5d6nA:
undetectable		 4duzL-5d6nA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ARG A  27
TRP A  56
GLY A 245
 None
 0.78A 4e7cA-5d6nA:
undetectable		 4e7cA-5d6nA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 110
ASP A 109
ILE A 131
VAL A 159
 None
 1.39A 4hytA-5d6nA:
undetectable		 4hytA-5d6nA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 TYR A 343
THR A 467
GLY A 482
ILE A 403
VAL A 417
 None
 1.19A 4jx1B-5d6nA:
undetectable		 4jx1B-5d6nA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  91
LEU A  98
LEU A 235
ILE A  82
ALA A 104
 None
 0.98A 4o2bD-5d6nA:
undetectable		 4o2bD-5d6nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.18A 4ojbA-5d6nA:
undetectable		 4ojbA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.16A 4ok1A-5d6nA:
undetectable		 4ok1A-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.14A 4okbA-5d6nA:
undetectable		 4okbA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.16A 4okxA-5d6nA:
undetectable		 4okxA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  98
GLY A  96
LEU A 132
VAL A 105
THR A  74
 None
 1.00A 4olmA-5d6nA:
undetectable		 4olmA-5d6nA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 401
GLY A 396
GLN A 210
ALA A 346
GLY A 344
 None
 1.16A 4r29A-5d6nA:
undetectable		 4r29A-5d6nA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
 1.47A 5mzrA-5d6nA:
undetectable		 5mzrA-5d6nA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
 1.46A 5mzrC-5d6nA:
undetectable		 5mzrC-5d6nA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ILE A 403
ILE A 420
VAL A 417
THR A 481
ILE A 480
 None
 1.48A 5mzrD-5d6nA:
undetectable		 5mzrD-5d6nA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5d6n ACYL-COA SYNTHASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 104
GLY A  77
THR A 180
LEU A 132
LEU A  70
 None
 1.25A 5nfjB-5d6nA:
undetectable		 5nfjB-5d6nA:
15.84