SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d6o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A 219
ALA A 215
SER A 211
TRP A 214
 None
None
None
GOL  A 407 (-4.4A)
 1.24A 1lqtA-5d6oA:
undetectable		 1lqtA-5d6oA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A 219
ALA A 215
SER A 211
TRP A 214
 None
None
None
GOL  A 407 (-4.4A)
 1.25A 1lquA-5d6oA:
undetectable		 1lquA-5d6oA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ALA A 145
VAL A 139
TRP A  65
 None
 0.85A 1nt5A-5d6oA:
undetectable		 1nt5A-5d6oA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 ALA A 145
VAL A 139
TRP A  65
 None
 0.85A 1nt5B-5d6oA:
undetectable		 1nt5B-5d6oA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 GLU A 333
ALA A 228
PHE A 244
LEU A 245
ASN A 330
 None
 1.22A 1nw3A-5d6oA:
undetectable		 1nw3A-5d6oA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 GLY A 140
ILE A  54
TRP A  57
SER A  85
 None
None
GOL  A 407 ( 4.1A)
None
 1.21A 1rs7A-5d6oA:
undetectable		 1rs7A-5d6oA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 TYR A 335
ARG A 317
ILE A 319
ASP A 340
 None
 1.06A 2xytE-5d6oA:
undetectable		 2xytE-5d6oA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 8 TYR A 335
ARG A 317
ILE A 319
ASP A 340
 None
 1.00A 2xytH-5d6oA:
undetectable		 2xytH-5d6oA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 PHE A 347
ALA A  75
ILE A  83
SER A  79
GLY A 140
 None
 1.22A 3lbdA-5d6oA:
undetectable		 3lbdA-5d6oA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 4 GLY A 116
GLU A  26
ASP A 268
ASP A 118
 None
 1.29A 3mb5A-5d6oA:
undetectable		 3mb5A-5d6oA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VXI_A_ASCA502_0
(DYP)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 ALA A  39
ASN A  87
PRO A  14
HIS A  62
 GOL  A 409 ( 3.7A)
None
GOL  A 409 ( 3.9A)
GOL  A 409 ( 4.7A)
 1.39A 3vxiA-5d6oA:
undetectable		 3vxiA-5d6oA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 SER A 220
GLY A 324
VAL A 331
ASP A 321
 None
 1.14A 4eohA-5d6oA:
2.1		 4eohA-5d6oA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 11 TRP A 214
ILE A 115
GLY A  60
PHE A 299
PHE A 298
 GOL  A 407 (-4.4A)
None
CL  A 402 ( 3.7A)
None
None
 1.13A 4qoiA-5d6oA:
3.0
4qoiB-5d6oA:
3.1		 4qoiA-5d6oA:
21.94
4qoiB-5d6oA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 GLU A 307
ILE A 115
ALA A 280
 None
 0.66A 4wnwB-5d6oA:
1.3		 4wnwB-5d6oA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 6 PHE A 244
SER A 211
PRO A 247
LEU A 241
 None
 1.32A 5dzka-5d6oA:
undetectable
5dzko-5d6oA:
undetectable		 5dzka-5d6oA:
22.07
5dzko-5d6oA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A 166
LEU A 328
GLY A 206
THR A 185
LEU A 213
 None
GOL  A 407 ( 4.8A)
None
None
None
 1.18A 5eshA-5d6oA:
undetectable		 5eshA-5d6oA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 ILE A 339
LEU A 343
ALA A 145
LEU A 328
HIS A 325
 None
None
None
GOL  A 407 ( 4.8A)
GOL  A 407 (-4.1A)
 1.07A 5km9B-5d6oA:
undetectable		 5km9B-5d6oA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  76
LEU A 343
TRP A  65
ALA A 162
LEU A 135
 None
 1.06A 5og9B-5d6oA:
undetectable		 5og9B-5d6oA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 12 LEU A  23
ILE A  31
VAL A 159
GLY A  90
LEU A  36
 None
 1.17A 6a7pA-5d6oA:
undetectable		 6a7pA-5d6oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ILE A  70
LEU A  76
ILE A  86
ALA A 163
 None
 0.71A 6b5vA-5d6oA:
0.0
6b5vC-5d6oA:
0.0		 6b5vA-5d6oA:
14.41
6b5vC-5d6oA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ILE A  70
LEU A  76
ILE A  86
ALA A 163
 None
 0.71A 6b5vC-5d6oA:
0.0
6b5vD-5d6oA:
undetectable		 6b5vC-5d6oA:
14.41
6b5vD-5d6oA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 7 ALA A 163
ILE A  70
LEU A  76
ILE A  86
 None
 0.68A 6b5vB-5d6oA:
undetectable
6b5vD-5d6oA:
undetectable		 6b5vB-5d6oA:
14.41
6b5vD-5d6oA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		5 / 9 LEU A  36
ARG A 127
ALA A 121
VAL A 119
ASP A 123
 None
GOL  A 408 (-4.3A)
None
None
None
 1.23A 6c2mB-5d6oA:
undetectable		 6c2mB-5d6oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		3 / 3 TRP A 224
GLU A 227
GLU A 238
 None
GOL  A 405 (-3.2A)
None
 0.48A 6fhwA-5d6oA:
undetectable		 6fhwA-5d6oA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5d6o HOMOSERINE
O-ACETYLTRANSFERASE
(Corynebacterium
glutamicum) 		4 / 5 GLN A  88
THR A  56
THR A  17
GLY A  90
 None
 1.03A 6gbnC-5d6oA:
4.8		 6gbnC-5d6oA:
22.60