SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 9 LEU A 268
LEU A 265
ILE A 309
THR A 325
ILE A 316
 None
 1.29A 1hzeA-5d6sA:
undetectable
1hzeB-5d6sA:
undetectable		 1hzeA-5d6sA:
15.06
1hzeB-5d6sA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 9 THR A 325
ILE A 316
LEU A 268
LEU A 265
ILE A 309
 None
 1.30A 1hzeA-5d6sA:
undetectable
1hzeB-5d6sA:
undetectable		 1hzeA-5d6sA:
15.06
1hzeB-5d6sA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 10 LEU A 268
LEU A 265
ILE A 309
THR A 325
ILE A 316
 None
 1.39A 1i18A-5d6sA:
undetectable
1i18B-5d6sA:
undetectable		 1i18A-5d6sA:
15.06
1i18B-5d6sA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 10 THR A 325
ILE A 316
LEU A 268
LEU A 265
ILE A 309
 None
 1.40A 1i18A-5d6sA:
undetectable
1i18B-5d6sA:
undetectable		 1i18A-5d6sA:
15.06
1i18B-5d6sA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		4 / 5 ASP A 305
LEU A 268
ALA A 299
LEU A 303
 None
 0.90A 1nh8A-5d6sA:
undetectable		 1nh8A-5d6sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 12 LEU A 268
ILE A 298
ALA A 299
THR A 327
LEU A 312
 None
 1.03A 2japA-5d6sA:
undetectable		 2japA-5d6sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 12 LEU A 268
ILE A 298
ALA A 299
THR A 327
LEU A 312
 None
 1.06A 2japB-5d6sA:
undetectable		 2japB-5d6sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 12 LEU A 268
ILE A 298
ALA A 299
THR A 327
LEU A 312
 None
 1.03A 2japC-5d6sA:
undetectable		 2japC-5d6sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 12 LEU A 268
ILE A 298
ALA A 299
THR A 327
LEU A 312
 None
 1.05A 2japD-5d6sA:
undetectable		 2japD-5d6sA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		4 / 6 SER A  33
VAL A 135
THR A  43
THR A  44
 B12  A 403 ( 4.0A)
B12  A 403 (-4.1A)
None
B12  A 403 (-3.8A)
 0.88A 3tneA-5d6sA:
undetectable		 3tneA-5d6sA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		3 / 3 TYR A 101
GLN A 216
TRP A  97
 B12  A 403 ( 4.9A)
B12  A 403 ( 4.2A)
None
 0.95A 4kn2C-5d6sA:
undetectable		 4kn2C-5d6sA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		4 / 7 ASN A 302
LYS A 230
LEU A 292
PHE A 275
 None
 1.08A 4yv5A-5d6sA:
undetectable		 4yv5A-5d6sA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		4 / 4 ASN A 251
SER A 161
ALA A  73
VAL A  72
 None
 1.26A 5nm5A-5d6sA:
undetectable		 5nm5A-5d6sA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 12 GLU A 179
ALA A 143
GLY A  20
THR A  22
LEU A 165
 None
None
None
None
B12  A 403 (-4.4A)
 0.92A 6f6iA-5d6sA:
undetectable
6f6iB-5d6sA:
undetectable		 6f6iA-5d6sA:
10.51
6f6iB-5d6sA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5d6s EPOXYQUEUOSINE
REDUCTASE
(Streptococcus
thermophilus) 		5 / 11 LEU A 172
PHE A  21
THR A  66
ILE A  19
ALA A 113
 None
 1.06A 6h1lB-5d6sA:
undetectable		 6h1lB-5d6sA:
23.42