SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.99A 1d4fC-5d7aA:
undetectable		 1d4fC-5d7aA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ALA A  52
GLY A 111
LEU A 160
ASP A 171
PHE A 172
 ALA  A  52 (-0.0A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
 0.51A 1xkkA-5d7aA:
24.8		 1xkkA-5d7aA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		8 / 11 VAL A  31
GLY A  32
GLY A  34
VAL A  39
ALA A  52
SER A 112
LEU A 160
ASP A 171
 VAL  A  31 (-0.6A)
GLY  A  32 ( 0.0A)
GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
SER  A 112 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.72A 2evaA-5d7aA:
26.3		 2evaA-5d7aA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  39
ALA A  52
GLU A  69
PHE A 107
GLY A 111
LEU A 160
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
GLU  A  69 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
 0.75A 2hyyB-5d7aA:
24.2		 2hyyB-5d7aA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  39
ALA A  52
GLY A 111
LEU A 160
ASP A 171
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
 0.55A 3bbtB-5d7aA:
24.1		 3bbtB-5d7aA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  39
ALA A  52
LEU A 103
GLY A 111
LEU A 160
ASP A 171
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LEU  A 103 ( 0.6A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
 0.76A 3bbtD-5d7aA:
24.7		 3bbtD-5d7aA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 LEU A 138
GLY A 220
ALA A 223
ILE A 133
GLY A 156
 LEU  A 138 ( 0.6A)
GLY  A 220 ( 0.0A)
ALA  A 223 ( 0.0A)
ILE  A 133 ( 0.6A)
GLY  A 156 ( 0.0A)
 1.07A 3ebzB-5d7aA:
undetectable		 3ebzB-5d7aA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 GLY A  32
GLY A  34
GLY A  37
VAL A  39
LYS A  54
SER A 112
ASN A 158
LEU A 160
ASP A 171
 GLY  A  32 ( 0.0A)
GLY  A  34 ( 0.0A)
GLY  A  37 ( 0.0A)
VAL  A  39 (-0.6A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.94A 3eygA-5d7aA:
24.2		 3eygA-5d7aA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 GLY A  32
GLY A  37
VAL A  39
ALA A  52
LYS A  54
SER A 112
ASN A 158
LEU A 160
ASP A 171
 GLY  A  32 ( 0.0A)
GLY  A  37 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.71A 3eygA-5d7aA:
24.2		 3eygA-5d7aA:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 VAL A  31
ALA A  52
LYS A  54
GLU A  69
LEU A  73
 VAL  A  31 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
 0.48A 3hecA-5d7aA:
17.9		 3hecA-5d7aA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  31
VAL A  39
ALA A  52
LYS A  54
GLU A  69
LEU A  73
 VAL  A  31 (-0.6A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
 0.72A 3hegA-5d7aA:
21.7		 3hegA-5d7aA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  39
ALA A  52
GLU A  69
PHE A 107
GLY A 111
LEU A 160
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
GLU  A  69 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
 0.78A 3k5vB-5d7aA:
23.7		 3k5vB-5d7aA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 8 VAL A  31
ALA A  52
LYS A  54
GLU A  69
LEU A 103
 VAL  A  31 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A 103 ( 0.6A)
 0.57A 3lfaA-5d7aA:
22.0		 3lfaA-5d7aA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.21A 3o94A-5d7aA:
undetectable		 3o94A-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.22A 3o94B-5d7aA:
undetectable		 3o94B-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.21A 3o94C-5d7aA:
undetectable		 3o94C-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 ASP A  14
GLU A  63
LEU A  18
ILE A  90
SER A  16
 ASP  A  14 ( 0.6A)
GLU  A  63 ( 0.6A)
LEU  A  18 ( 0.6A)
ILE  A  90 ( 0.7A)
SER  A  16 ( 0.0A)
 1.21A 3o94D-5d7aA:
undetectable		 3o94D-5d7aA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 VAL A  39
ALA A  52
LYS A  54
LEU A  73
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
PHE  A 172 ( 1.3A)
 0.67A 3og7A-5d7aA:
25.5		 3og7A-5d7aA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_1
(P38A)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  31
GLY A  32
VAL A  39
ALA A  52
LYS A  54
LEU A  73
 VAL  A  31 (-0.6A)
GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
 0.43A 3ohtA-5d7aA:
18.3		 3ohtA-5d7aA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 GLY A  32
VAL A  39
ALA A  52
LYS A  54
LEU A  73
GLY A 111
 GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
GLY  A 111 (-0.0A)
 0.69A 3ohtB-5d7aA:
18.3		 3ohtB-5d7aA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 VAL A  39
ALA A  52
GLU A  69
PHE A 107
GLY A 111
LEU A 160
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
GLU  A  69 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
 0.84A 3pyyA-5d7aA:
23.9		 3pyyA-5d7aA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 VAL A  39
ALA A  52
LYS A  54
LEU A 103
MET A 105
GLY A 111
LEU A 160
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A 103 ( 0.6A)
MET  A 105 (-0.0A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
 0.90A 3ug2A-5d7aA:
16.0		 3ug2A-5d7aA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 ILE A 154
ILE A 130
ILE A 137
ARG A 277
LEU A 253
 ILE  A 154 ( 0.7A)
ILE  A 130 ( 0.7A)
ILE  A 137 ( 0.7A)
ARG  A 277 ( 0.6A)
LEU  A 253 ( 0.6A)
 1.03A 3uj6A-5d7aA:
undetectable		 3uj6A-5d7aA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		8 / 12 VAL A  39
ALA A  52
LYS A  54
LEU A  73
PHE A 107
GLY A 111
LEU A 144
HIS A 151
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.71A 3wzeA-5d7aA:
8.8		 3wzeA-5d7aA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 VAL A  39
ALA A  52
LYS A  54
GLU A  69
LEU A  73
PHE A 107
GLY A 111
LEU A 144
HIS A 151
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.79A 4asdA-5d7aA:
10.1		 4asdA-5d7aA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		7 / 12 ALA A  52
LYS A  54
GLU A  69
LEU A  73
ILE A  82
HIS A 151
LEU A 160
 ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
ILE  A  82 ( 0.7A)
HIS  A 151 ( 1.0A)
LEU  A 160 (-0.6A)
 0.91A 4c8bB-5d7aA:
25.6		 4c8bB-5d7aA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 GLY A  32
VAL A  39
ALA A  52
LEU A 103
MET A 105
GLY A 111
ASP A 115
LEU A 160
ASP A 171
 GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LEU  A 103 ( 0.6A)
MET  A 105 (-0.0A)
GLY  A 111 (-0.0A)
ASP  A 115 (-0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.94A 4i22A-5d7aA:
14.3		 4i22A-5d7aA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		9 / 12 GLY A  32
VAL A  39
ALA A  52
LYS A  54
LEU A 103
MET A 105
GLY A 111
LEU A 160
ASP A 171
 GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A 103 ( 0.6A)
MET  A 105 (-0.0A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.83A 4i22A-5d7aA:
14.3		 4i22A-5d7aA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 10 ALA A  52
MET A 105
PHE A 107
GLY A 111
LEU A 160
ASP A 171
 ALA  A  52 (-0.0A)
MET  A 105 (-0.0A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 1.03A 4ks8A-5d7aA:
29.9		 4ks8A-5d7aA:
37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 LEU A  73
ASN A 158
ASP A 171
PHE A 172
GLY A 173
 LEU  A  73 ( 0.6A)
ASN  A 158 ( 0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
GLY  A 173 ( 0.0A)
 0.72A 4lmnA-5d7aA:
29.6		 4lmnA-5d7aA:
30.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 MET A 105
ASN A 158
ASP A 171
PHE A 172
GLY A 173
 MET  A 105 (-0.0A)
ASN  A 158 ( 0.6A)
ASP  A 171 ( 0.5A)
PHE  A 172 ( 1.3A)
GLY  A 173 ( 0.0A)
 1.00A 4lmnA-5d7aA:
29.6		 4lmnA-5d7aA:
30.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 8 GLY A  34
VAL A  39
ALA A  52
ASN A 158
LEU A 160
ASP A 171
 GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.58A 4ogrA-5d7aA:
26.3		 4ogrA-5d7aA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 9 GLY A  34
VAL A  39
ALA A  52
ASN A 158
LEU A 160
ASP A 171
 GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
ASN  A 158 ( 0.6A)
LEU  A 160 (-0.6A)
ASP  A 171 ( 0.5A)
 0.53A 4ogrI-5d7aA:
26.7		 4ogrI-5d7aA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 6 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.84A 4pgfA-5d7aA:
undetectable		 4pgfA-5d7aA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 GLY A  32
VAL A  39
ALA A  52
MET A 105
GLY A 109
LEU A 160
 GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
MET  A 105 (-0.0A)
GLY  A 109 ( 0.0A)
LEU  A 160 (-0.6A)
 0.51A 4qmzA-5d7aA:
24.6		 4qmzA-5d7aA:
43.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RZV_B_032B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 12 VAL A  39
ALA A  52
LYS A  54
SER A 112
PHE A 172
 VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
SER  A 112 (-0.0A)
PHE  A 172 ( 1.3A)
 0.65A 4rzvB-5d7aA:
25.4		 4rzvB-5d7aA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 LYS A 186
ARG A 152
VAL A 174
 ASN  A 186 ( 0.0A)
ARG  A 152 ( 0.6A)
VAL  A 174 ( 0.6A)
 0.88A 4x3uA-5d7aA:
undetectable
4x3uB-5d7aA:
undetectable		 4x3uA-5d7aA:
10.97
4x3uB-5d7aA:
10.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 ALA A  52
LYS A  54
GLU A  69
LEU A  73
LEU A 144
HIS A 151
 ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
GLU  A  69 ( 0.6A)
LEU  A  73 ( 0.6A)
LEU  A 144 ( 0.6A)
HIS  A 151 ( 1.0A)
 0.92A 5hi2A-5d7aA:
24.7		 5hi2A-5d7aA:
31.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5HIE_C_P06C801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 GLY A  32
GLY A  34
VAL A  39
ALA A  52
LYS A  54
ASP A 171
 GLY  A  32 ( 0.0A)
GLY  A  34 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
ASP  A 171 ( 0.5A)
 0.83A 5hieC-5d7aA:
25.8		 5hieC-5d7aA:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		6 / 12 GLU A  29
ALA A  52
GLU A  69
PHE A 107
GLY A 111
LEU A 160
 GLU  A  29 ( 0.6A)
ALA  A  52 (-0.0A)
GLU  A  69 ( 0.6A)
PHE  A 107 ( 1.3A)
GLY  A 111 (-0.0A)
LEU  A 160 (-0.6A)
 0.65A 5te0A-5d7aA:
24.8		 5te0A-5d7aA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		3 / 3 LEU A 242
ILE A 200
TYR A 210
 LEU  A 242 ( 0.6A)
ILE  A 200 ( 0.7A)
TYR  A 210 ( 1.3A)
 0.63A 5uunB-5d7aA:
undetectable		 5uunB-5d7aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.92A 6aphA-5d7aA:
undetectable		 6aphA-5d7aA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		4 / 5 THR A 222
THR A 280
HIS A 145
LEU A 169
 THR  A 222 ( 0.8A)
THR  A 280 ( 0.8A)
HIS  A 145 ( 1.0A)
LEU  A 169 ( 0.6A)
 0.92A 6gbnB-5d7aA:
undetectable		 6gbnB-5d7aA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE
(Homo
sapiens) 		5 / 11 LEU A 283
THR A 280
GLY A 140
ILE A 137
ILE A 289
 LEU  A 283 ( 0.6A)
THR  A 280 ( 0.8A)
GLY  A 140 ( 0.0A)
ILE  A 137 ( 0.7A)
ILE  A 289 ( 0.7A)
 1.08A 6gp2A-5d7aA:
undetectable		 6gp2A-5d7aA:
12.33