SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 5 LEU A 310
SER A 228
LEU A 264
GLY A 278
 None
 1.07A 1a4lB-5d8gA:
undetectable		 1a4lB-5d8gA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 9 VAL A 362
VAL A 442
LEU A 385
ILE A 348
LEU A 367
 CME  A 352 ( 4.0A)
None
None
None
None
 1.04A 1eqgA-5d8gA:
undetectable		 1eqgA-5d8gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 11 VAL A 362
VAL A 442
LEU A 385
ILE A 348
LEU A 367
 CME  A 352 ( 4.0A)
None
None
None
None
 1.03A 1eqgB-5d8gA:
undetectable		 1eqgB-5d8gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 11 LEU A 210
LEU A 207
ALA A 208
GLU A 242
LEU A 173
 None
 1.27A 1g50A-5d8gA:
undetectable		 1g50A-5d8gA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 10 LEU A 210
LEU A 207
ALA A 208
GLU A 242
LEU A 173
 None
 1.23A 1gwrA-5d8gA:
undetectable		 1gwrA-5d8gA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 11 LEU A 279
GLY A 278
GLY A 277
LEU A 310
LEU A  83
 None
 1.15A 1mx1A-5d8gA:
undetectable		 1mx1A-5d8gA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 11 LEU A 322
ALA A 268
VAL A  87
MET A 266
LEU A 264
 None
 1.22A 1qabE-5d8gA:
undetectable		 1qabE-5d8gA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 10 LEU A 322
ALA A 268
VAL A  87
MET A 266
LEU A 264
 None
 1.19A 1rlbE-5d8gA:
undetectable		 1rlbE-5d8gA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 LEU A 367
HIS A 370
ILE A 371
 None
 0.58A 1s9pB-5d8gA:
undetectable		 1s9pB-5d8gA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 ASP A 172
GLU A 182
TYR A 220
 None
 0.84A 1wsvA-5d8gA:
undetectable		 1wsvA-5d8gA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 5 ILE A  31
LEU A 452
ALA A 380
GLU A 384
 None
 1.17A 1xvaA-5d8gA:
3.5
1xvaB-5d8gA:
3.5		 1xvaA-5d8gA:
21.74
1xvaB-5d8gA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 GLN A 107
HIS A 142
ARG A 103
 None
 0.77A 1zlqA-5d8gA:
undetectable		 1zlqA-5d8gA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 ARG A 241
GLN A 203
PRO A 204
 None
 0.97A 2qhfA-5d8gA:
undetectable		 2qhfA-5d8gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 PHE A  39
ASN A  37
PHE A 399
 None
 1.09A 2zbuD-5d8gA:
undetectable		 2zbuD-5d8gA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 5 GLN A 140
THR A 138
HIS A 463
LEU A 400
 None
None
None
EPE  A1003 (-4.3A)
 1.15A 2zj0A-5d8gA:
2.8		 2zj0A-5d8gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 11 LEU A 322
ALA A 268
VAL A  87
MET A 266
LEU A 264
 None
 1.26A 3bszE-5d8gA:
undetectable		 3bszE-5d8gA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 5 GLN A 140
THR A 138
HIS A 463
LEU A 400
 None
None
None
EPE  A1003 (-4.3A)
 1.19A 3ce6A-5d8gA:
undetectable		 3ce6A-5d8gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 5 GLN A 140
THR A 138
HIS A 463
LEU A 400
 None
None
None
EPE  A1003 (-4.3A)
 1.16A 3ce6C-5d8gA:
2.4		 3ce6C-5d8gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 5 GLN A 140
THR A 138
HIS A 463
LEU A 400
 None
None
None
EPE  A1003 (-4.3A)
 1.17A 3ce6D-5d8gA:
undetectable		 3ce6D-5d8gA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 10 ALA A 208
ASN A 133
GLU A 242
ALA A 193
ILE A 195
 None
 1.10A 3fl9F-5d8gA:
undetectable		 3fl9F-5d8gA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 ASP A 324
ASN A 327
SER A  62
 None
 1.02A 3lsfB-5d8gA:
undetectable
3lsfE-5d8gA:
undetectable		 3lsfB-5d8gA:
20.97
3lsfE-5d8gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 ASP A 324
ASN A 327
SER A  62
 None
 0.91A 3lslA-5d8gA:
undetectable
3lslD-5d8gA:
undetectable		 3lslA-5d8gA:
20.97
3lslD-5d8gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 SER A  62
ASP A 324
ASN A 327
 None
 0.91A 3lslA-5d8gA:
undetectable
3lslD-5d8gA:
0.7		 3lslA-5d8gA:
20.97
3lslD-5d8gA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 7 ILE A  90
LEU A 318
THR A  60
ARG A 230
 None
 1.03A 3nxuA-5d8gA:
undetectable		 3nxuA-5d8gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 11 ILE A 422
THR A 421
ALA A 393
LEU A  50
LEU A 341
 MG  A1005 (-4.9A)
MG  A1005 (-4.5A)
None
None
None
 1.07A 4g1bB-5d8gA:
undetectable		 4g1bB-5d8gA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 11 PHE A 237
GLY A 356
GLY A 357
ALA A 360
GLN A 337
 None
None
None
CME  A 352 ( 4.2A)
None
 1.17A 4l8fD-5d8gA:
3.1		 4l8fD-5d8gA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 5 THR A 139
THR A 138
HIS A 358
ASN A 133
 None
 1.41A 4pgfB-5d8gA:
2.8		 4pgfB-5d8gA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 12 ALA A  58
HIS A   6
PHE A  11
GLU A   9
TYR A 333
 None
 1.48A 4r7lA-5d8gA:
undetectable		 4r7lA-5d8gA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 12 LEU A 452
LEU A 461
PHE A  39
LEU A 418
ARG A 419
 None
None
None
None
EPE  A1003 (-2.9A)
 1.19A 4retA-5d8gA:
2.9		 4retA-5d8gA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		3 / 3 CYH A 383
MET A  36
ASN A  37
 None
 1.17A 5qh8A-5d8gA:
undetectable		 5qh8A-5d8gA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		4 / 7 ILE A  90
LEU A 318
THR A  60
ARG A 230
 None
 1.04A 5vc0A-5d8gA:
undetectable		 5vc0A-5d8gA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5d8g TRYPTOPHANASE
(Escherichia
coli) 		5 / 9 LEU A 176
ILE A 222
PRO A 185
VAL A 188
ILE A 180
 None
 1.28A 6ef6A-5d8gA:
undetectable		 6ef6A-5d8gA:
21.84