SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 11 TYR A 408
ILE A 405
LEU A 365
PRO A 369
LEU A 138
 None
 1.47A 1mrlA-5d8mA:
undetectable
1mrlB-5d8mA:
undetectable		 1mrlA-5d8mA:
16.43
1mrlB-5d8mA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 8 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.15A 1p7lC-5d8mA:
undetectable		 1p7lC-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 8 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.15A 1p7lD-5d8mA:
undetectable		 1p7lD-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 12 GLU A 410
ILE A 226
ASP A 224
GLY A 160
ILE A 161
 None
 1.15A 1q8jA-5d8mA:
undetectable		 1q8jA-5d8mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 12 GLU A 410
ILE A 226
ASP A 224
GLY A 160
SER A 157
 None
 1.49A 1q8jA-5d8mA:
undetectable		 1q8jA-5d8mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 8 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.15A 1rg9A-5d8mA:
undetectable		 1rg9A-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 8 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.15A 1rg9B-5d8mA:
undetectable		 1rg9B-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 8 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.14A 1rg9C-5d8mA:
undetectable		 1rg9C-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 8 PRO A 399
ASP A 183
SER A 178
THR A 388
 None
 1.15A 1rg9D-5d8mA:
undetectable		 1rg9D-5d8mA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 7 LEU A 180
ASN A 209
ILE A 213
ASP A 237
 None
 0.90A 1yc2E-5d8mA:
2.4		 1yc2E-5d8mA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 7 SER A 232
LEU A 169
GLY A 351
ASP A 350
 None
 1.04A 2ddwB-5d8mA:
4.9		 2ddwB-5d8mA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 6 ASP A 224
ARG A 251
ILE A 161
SER A 157
 None
 1.50A 3ckzA-5d8mA:
undetectable		 3ckzA-5d8mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		3 / 3 ASP A 237
SER A 206
ARG A 304
 None
 0.89A 3loqA-5d8mA:
undetectable		 3loqA-5d8mA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 11 THR A 252
THR A 230
LEU A 242
VAL A 198
VAL A 166
 None
 1.25A 3lxiB-5d8mA:
undetectable		 3lxiB-5d8mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 9 VAL A 353
LEU A 239
ILE A 262
ALA A 358
THR A 230
 None
 1.04A 3mdvA-5d8mA:
undetectable		 3mdvA-5d8mA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 10 THR A 252
THR A 230
LEU A 242
VAL A 198
VAL A 166
 None
 1.29A 4c9nB-5d8mA:
undetectable		 4c9nB-5d8mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 9 THR A 252
THR A 230
LEU A 242
VAL A 198
VAL A 166
 None
 1.27A 4c9pA-5d8mA:
undetectable		 4c9pA-5d8mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 12 GLU A 410
ILE A 226
ASP A 224
GLY A 160
SER A 157
 None
 1.44A 4djfA-5d8mA:
undetectable		 4djfA-5d8mA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 9 THR A 252
THR A 230
LEU A 242
VAL A 198
VAL A 166
 None
 1.20A 4ek1B-5d8mA:
undetectable		 4ek1B-5d8mA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 4 ASP A 412
LEU A 413
ARG A 316
THR A 364
 None
 1.46A 4kjjA-5d8mA:
undetectable		 4kjjA-5d8mA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 8 LEU A 366
PRO A 369
VAL A 376
HIS A 231
 None
 0.98A 4qknA-5d8mA:
undetectable		 4qknA-5d8mA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		5 / 12 ARG A 185
ILE A 213
LEU A 165
VAL A 198
ILE A 212
 None
 1.01A 4uw0A-5d8mA:
1.8		 4uw0A-5d8mA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 5 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 1.09A 5dzkb-5d8mA:
2.2
5dzkp-5d8mA:
undetectable		 5dzkb-5d8mA:
22.62
5dzkp-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 6 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 0.98A 5dzkB-5d8mA:
2.3
5dzkP-5d8mA:
undetectable		 5dzkB-5d8mA:
22.62
5dzkP-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 5 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 1.04A 5dzkc-5d8mA:
undetectable
5dzkq-5d8mA:
undetectable		 5dzkc-5d8mA:
22.62
5dzkq-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 7 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 0.83A 5dzkD-5d8mA:
undetectable
5dzkR-5d8mA:
undetectable		 5dzkD-5d8mA:
22.62
5dzkR-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 5 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 0.91A 5dzkf-5d8mA:
2.3
5dzkt-5d8mA:
undetectable		 5dzkf-5d8mA:
22.62
5dzkt-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 6 SER A 232
ALA A 261
HIS A 231
LEU A 352
 None
 1.04A 5dzkg-5d8mA:
undetectable
5dzku-5d8mA:
undetectable		 5dzkg-5d8mA:
22.62
5dzku-5d8mA:
2.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		3 / 3 VAL A 166
HIS A 214
VAL A 217
 None
 0.63A 5jmnC-5d8mA:
undetectable		 5jmnC-5d8mA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 7 ILE A 405
LEU A 401
ILE A 359
ALA A 371
 None
 0.82A 6b5vA-5d8mA:
undetectable
6b5vC-5d8mA:
undetectable		 6b5vA-5d8mA:
11.80
6b5vC-5d8mA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 7 ILE A 405
LEU A 401
ILE A 359
ALA A 371
 None
 0.82A 6b5vC-5d8mA:
undetectable
6b5vD-5d8mA:
undetectable		 6b5vC-5d8mA:
11.80
6b5vD-5d8mA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5d8m METAGENOMIC CARBOXYL
ESTERASE MGS0156
(uncultured
organism) 		4 / 7 ALA A 371
ILE A 405
LEU A 401
ILE A 359
 None
 0.82A 6b5vB-5d8mA:
undetectable
6b5vD-5d8mA:
undetectable		 6b5vB-5d8mA:
11.80
6b5vD-5d8mA:
11.80