SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d91'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		4 / 8 LEU A -80
ALA A-127
PHE A -97
VAL A -95
 None
 0.83A 1epbB-5d91A:
undetectable		 1epbB-5d91A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		5 / 10 LEU A -71
ALA A  -5
LEU A  -1
LEU A -13
LEU A-110
 None
 1.34A 1ie4A-5d91A:
undetectable
1ie4C-5d91A:
undetectable		 1ie4A-5d91A:
17.52
1ie4C-5d91A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		5 / 12 LEU A 174
LEU A 177
LEU A 180
ALA A 181
LEU A 125
 8K6  A 337 ( 4.9A)
None
None
None
None
 0.99A 1s9pC-5d91A:
undetectable		 1s9pC-5d91A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		4 / 5 LEU A 120
PRO A 113
ALA A 116
ILE A 117
 None
None
None
8K6  A 305 ( 4.1A)
 1.03A 2aofB-5d91A:
undetectable		 2aofB-5d91A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		5 / 12 VAL A 156
PHE A  99
TYR A  47
VAL A 176
LEU A 173
 None
 1.47A 4po0A-5d91A:
1.9		 4po0A-5d91A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		5 / 11 LEU A  90
LEU A  37
ILE A  59
GLY A  42
LEU A  44
 None
8K6  A 334 ( 4.7A)
None
None
8K6  A 335 (-4.3A)
 1.22A 4pxmB-5d91A:
undetectable		 4pxmB-5d91A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Archaeoglobus
fulgidus;
Renibacterium
salmoninarum) 		4 / 6 VAL A 157
LEU A 125
SER A 126
ILE A 188
 None
 1.01A 5jw1A-5d91A:
0.6		 5jw1A-5d91A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Renibacterium
salmoninarum;
Archaeoglobus
fulgidus) 		3 / 3 ARG A-129
PHE A -48
LEU A -65
 None
 0.52A 5x1bC-5d91A:
2.4		 5x1bC-5d91A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Renibacterium
salmoninarum;
Archaeoglobus
fulgidus) 		3 / 3 TYR A-119
ARG A-109
THR A-111
 None
 1.01A 5z84J-5d91A:
undetectable		 5z84J-5d91A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 5d91 AF2299
PROTEIN,PHOSPHATIDYL
INOSITOL SYNTHASE
(Renibacterium
salmoninarum;
Archaeoglobus
fulgidus) 		3 / 3 ARG A  92
ARG A 150
ASP A  95
 None
 0.85A 6d8pA-5d91A:
undetectable		 6d8pA-5d91A:
18.31