SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5d9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 12 LEU B 323
GLY B 475
ASN B 477
ALA B 319
LEU B  90
None
0.99A 1bx4A-5d9aB:
undetectable
1bx4A-5d9aB:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus;
Influenza
C
virus)
4 / 8 SER B  58
SER A 198
ARG B  65
PHE B  61
None
1.30A 1eqbA-5d9aB:
undetectable
1eqbB-5d9aB:
undetectable
1eqbA-5d9aB:
20.13
1eqbB-5d9aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus;
Influenza
C
virus)
4 / 8 PHE B  61
SER B  58
SER A 198
ARG B  65
None
1.31A 1eqbA-5d9aB:
undetectable
1eqbB-5d9aB:
undetectable
1eqbA-5d9aB:
20.13
1eqbB-5d9aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus;
Influenza
C
virus)
4 / 8 SER B  58
SER A 198
ARG B  65
PHE B  61
None
1.31A 1eqbC-5d9aB:
undetectable
1eqbD-5d9aB:
undetectable
1eqbC-5d9aB:
20.13
1eqbD-5d9aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus;
Influenza
C
virus)
4 / 8 PHE B  61
SER B  58
SER A 198
ARG B  65
None
1.31A 1eqbC-5d9aB:
undetectable
1eqbD-5d9aB:
undetectable
1eqbC-5d9aB:
20.13
1eqbD-5d9aB:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 12 ILE B 304
PHE B 491
GLY B 306
SER B 444
LEU B 284
None
1.44A 1fm6X-5d9aB:
undetectable
1fm6X-5d9aB:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)
5d9a POLYMERASE ACIDIC
PROTEIN
POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
5 / 10 GLY A  66
VAL C 767
ALA A  24
ALA A  21
ILE A  38
None
1.10A 1likA-5d9aA:
2.1
1likA-5d9aA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
3 / 3 PHE B 105
LEU B 268
MET B 415
None
0.80A 1mx1D-5d9aB:
undetectable
1mx1D-5d9aB:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
5 / 10 GLY A 293
ASP A 288
ILE A 287
ILE A 324
ILE A 298
None
1.02A 1sh9B-5d9aA:
undetectable
1sh9B-5d9aA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 LEU B 442
GLN B 443
LEU B 284
PHE B 498
None
1.04A 1v55C-5d9aB:
undetectable
1v55J-5d9aB:
undetectable
1v55C-5d9aB:
16.47
1v55J-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 5 ILE A 287
SER A 275
ARG A 279
LEU A 286
None
1.11A 1y0xX-5d9aA:
undetectable
1y0xX-5d9aA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 SER B 444
GLU B 492
SER B 483
ASP B 446
None
1.33A 2cl5B-5d9aB:
undetectable
2cl5B-5d9aB:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 LEU B 442
GLN B 443
LEU B 284
PHE B 498
None
1.05A 2dysP-5d9aB:
undetectable
2dysW-5d9aB:
undetectable
2dysP-5d9aB:
16.47
2dysW-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 LEU B 442
GLN B 443
LEU B 284
PHE B 498
None
1.04A 2eijC-5d9aB:
undetectable
2eijJ-5d9aB:
undetectable
2eijC-5d9aB:
16.47
2eijJ-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 LEU B 442
GLN B 443
LEU B 284
PHE B 498
None
0.91A 2eimC-5d9aB:
undetectable
2eimJ-5d9aB:
undetectable
2eimC-5d9aB:
16.47
2eimJ-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 LEU B 442
GLN B 443
LEU B 284
PHE B 498
None
1.00A 2einC-5d9aB:
undetectable
2einJ-5d9aB:
undetectable
2einC-5d9aB:
16.47
2einJ-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 LEU B 442
GLN B 443
LEU B 284
PHE B 498
None
1.13A 2einP-5d9aB:
undetectable
2einW-5d9aB:
undetectable
2einP-5d9aB:
16.47
2einW-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 GLU B 489
ASN B 292
PRO B 488
ALA B 301
None
1.21A 2ejgA-5d9aB:
1.4
2ejgA-5d9aB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 GLU B 489
ASN B 292
PRO B 488
ALA B 301
None
1.17A 2ejgB-5d9aB:
1.6
2ejgB-5d9aB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 8 THR B 515
VAL B 522
ALA B 593
ARG B 573
None
0.92A 2ij7C-5d9aB:
undetectable
2ij7C-5d9aB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 5 LEU A 691
LEU A 678
CYH A 643
THR B  21
None
1.36A 2oaxD-5d9aA:
undetectable
2oaxD-5d9aA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 7 ILE C 572
TYR C 568
TYR C 685
PHE C 674
None
1.15A 2qebB-5d9aC:
undetectable
2qebB-5d9aC:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
5 / 12 SER C 317
VAL C 320
THR C 295
ARG C 267
ILE C 266
None
1.33A 2vdyA-5d9aC:
undetectable
2vdyA-5d9aC:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus;
Influenza
C
virus)
3 / 3 HIS B  32
MET A 501
MET B  30
None
0.98A 2vj1A-5d9aB:
undetectable
2vj1A-5d9aB:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 4 ARG A 433
GLY A 436
GLU A 434
SER A 280
None
1.14A 2xctS-5d9aA:
undetectable
2xctU-5d9aA:
undetectable
2xctS-5d9aA:
22.57
2xctU-5d9aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 8 ILE C 572
VAL C 673
SER C 633
TYR C 568
None
0.96A 2yoeB-5d9aC:
undetectable
2yoeC-5d9aC:
undetectable
2yoeB-5d9aC:
16.88
2yoeC-5d9aC:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus;
Influenza
C
virus)
4 / 5 TYR C  11
GLU B 716
ARG B 750
ASP C 177
None
1.37A 2yqzA-5d9aC:
undetectable
2yqzA-5d9aC:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus;
Influenza
C
virus)
4 / 5 TYR C  11
GLU B 716
ARG B 750
ASP C 177
None
1.35A 2yqzB-5d9aC:
undetectable
2yqzB-5d9aC:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 SER B 444
GLU B 492
SER B 483
ASP B 446
None
1.29A 2zvjA-5d9aB:
undetectable
2zvjA-5d9aB:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 LEU B 442
GLN B 443
LEU B 284
PHE B 498
None
1.00A 2zxwP-5d9aB:
undetectable
2zxwW-5d9aB:
undetectable
2zxwP-5d9aB:
16.47
2zxwW-5d9aB:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 12 LEU B 148
ALA B 152
ILE B 181
ASP B 151
GLU B 682
None
1.16A 3axtA-5d9aB:
undetectable
3axtA-5d9aB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
3 / 3 TRP A 388
VAL A 399
ARG B 550
None
0.86A 3b0wA-5d9aA:
undetectable
3b0wA-5d9aA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
5 / 12 GLN A 427
CYH A 483
LEU A 440
CYH A 438
PHE A 629
None
1.35A 3cldA-5d9aA:
undetectable
3cldA-5d9aA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
5 / 12 GLN A 427
MET A 270
CYH A 483
LEU A 440
CYH A 438
None
1.28A 3cldB-5d9aA:
undetectable
3cldB-5d9aA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
5 / 12 MET A 270
CYH A 483
LEU A 440
CYH A 438
PHE A 629
None
1.26A 3cldB-5d9aA:
undetectable
3cldB-5d9aA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus;
Influenza
C
virus)
5 / 12 THR A 190
ALA B 223
VAL B 341
ILE B 181
THR B 149
None
1.23A 3dl9A-5d9aA:
undetectable
3dl9A-5d9aA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 7 GLY A  66
HIS A  41
ASP A  93
ILE A  94
None
0.93A 3fi0P-5d9aA:
undetectable
3fi0P-5d9aA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
5 / 12 CYH A 570
THR A 573
THR A 574
THR A 577
LEU A 426
None
0.98A 3gwxA-5d9aA:
undetectable
3gwxA-5d9aA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
5 / 12 CYH A 570
THR A 573
THR A 574
THR A 577
LEU A 426
None
0.97A 3gwxB-5d9aA:
undetectable
3gwxB-5d9aA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
3 / 3 MET C  67
CYH C 111
PRO B 628
None
0.80A 3h52C-5d9aC:
undetectable
3h52C-5d9aC:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
3 / 3 GLU A 266
GLU A 267
TRP A 381
None
1.34A 3hrdA-5d9aA:
undetectable
3hrdE-5d9aA:
undetectable
3hrdF-5d9aA:
undetectable
3hrdA-5d9aA:
20.77
3hrdE-5d9aA:
20.77
3hrdF-5d9aA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
3 / 3 THR B  57
LYS B 379
GLU B  55
None
1.01A 3ijdB-5d9aB:
undetectable
3ijdB-5d9aB:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 8 GLU A 385
ASN A 383
MET A 387
ILE A 390
None
1.23A 3kp6A-5d9aA:
1.9
3kp6B-5d9aA:
2.5
3kp6A-5d9aA:
13.93
3kp6B-5d9aA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 6 MET A 387
ILE A 390
GLU A 385
ASN A 383
None
1.12A 3kp6A-5d9aA:
1.8
3kp6B-5d9aA:
2.5
3kp6A-5d9aA:
13.93
3kp6B-5d9aA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 ILE A 350
GLU B 367
LYS B 366
ASN B 361
None
1.40A 3kp6A-5d9aA:
1.8
3kp6B-5d9aA:
2.5
3kp6A-5d9aA:
13.93
3kp6B-5d9aA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 8 ASP C 590
TYR C 595
LEU C 597
LEU C 585
None
0.98A 3lm8A-5d9aC:
undetectable
3lm8C-5d9aC:
undetectable
3lm8A-5d9aC:
13.81
3lm8C-5d9aC:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 8 ASP C 590
TYR C 595
LEU C 597
LEU C 585
None
0.98A 3lm8B-5d9aC:
undetectable
3lm8D-5d9aC:
undetectable
3lm8B-5d9aC:
13.81
3lm8D-5d9aC:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 7 TYR A  83
ASP A  96
LYS A 100
SER A  54
None
1.30A 3lslA-5d9aA:
undetectable
3lslD-5d9aA:
undetectable
3lslA-5d9aA:
17.23
3lslD-5d9aA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 7 SER A  54
TYR A  83
ASP A  96
LYS A 100
None
1.39A 3lslA-5d9aA:
undetectable
3lslD-5d9aA:
undetectable
3lslA-5d9aA:
17.23
3lslD-5d9aA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 8 LEU A 639
CYH A 684
GLN A 646
PHE A 631
None
1.28A 3po7A-5d9aA:
undetectable
3po7A-5d9aA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 GLU B  77
ASP B  48
TYR B  49
LYS B  44
None
1.42A 3pocB-5d9aB:
undetectable
3pocB-5d9aB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
3 / 3 THR C 321
ASP C 524
GLU C 515
None
0.85A 3qowA-5d9aC:
undetectable
3qowA-5d9aC:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 8 ASP C 581
GLY C 578
GLU C 599
ARG C 757
None
1.00A 3s3mA-5d9aC:
undetectable
3s3mA-5d9aC:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 8 ASP C 581
GLY C 578
GLU C 599
ARG C 757
None
1.01A 3s3nA-5d9aC:
undetectable
3s3nA-5d9aC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 ILE B  18
LYS B 482
LYS B 237
GLY B 236
None
1.19A 3sj0X-5d9aB:
undetectable
3sj0X-5d9aB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 5 ILE A 238
PRO A 667
SER A 662
GLY A 664
None
0.98A 3tkdB-5d9aA:
undetectable
3tkdB-5d9aA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 5 ILE A 238
PRO A 667
SER A 662
GLY A 664
None
0.96A 3tkdA-5d9aA:
undetectable
3tkdA-5d9aA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus;
Influenza
C
virus)
3 / 3 LYS B 747
ARG C 739
LEU B 719
None
1.29A 3v4tE-5d9aB:
undetectable
3v4tE-5d9aB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
5 / 12 SER C 317
VAL C 320
THR C 295
ARG C 267
ILE C 266
None
1.38A 4c49B-5d9aC:
undetectable
4c49B-5d9aC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
5 / 12 SER C 317
VAL C 320
THR C 295
ARG C 267
ILE C 266
None
1.37A 4c49C-5d9aC:
undetectable
4c49C-5d9aC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
5 / 12 SER C 317
VAL C 320
THR C 295
ARG C 267
ILE C 266
None
1.39A 4c49D-5d9aC:
undetectable
4c49D-5d9aC:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 5 PHE A 156
PHE A  12
ILE A  40
GLY A  39
None
0.93A 4ejjC-5d9aA:
undetectable
4ejjC-5d9aA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 7 GLY C 338
MET C 450
TYR C 447
ASN C 451
None
1.07A 4fgkB-5d9aC:
undetectable
4fgkB-5d9aC:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 8 GLY C 745
PRO B 704
PHE B 692
ILE B 710
None
0.97A 4j4vC-5d9aC:
undetectable
4j4vC-5d9aC:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 12 PRO B 631
ALA C  71
ILE B 576
ARG B 573
GLY B 572
None
1.35A 4l9qA-5d9aB:
3.6
4l9qA-5d9aB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus;
Influenza
C
virus)
4 / 8 GLY B 128
THR B 131
LEU B 146
TRP C  38
None
1.09A 4m5mA-5d9aB:
undetectable
4m5mA-5d9aB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 8 GLY C 332
LEU C 341
LEU C 342
LYS C 344
None
0.69A 4mwzB-5d9aC:
undetectable
4mwzB-5d9aC:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 11 VAL B 419
LEU B 416
LEU B  90
LEU B 323
ALA B 319
None
1.13A 4p65B-5d9aB:
undetectable
4p65D-5d9aB:
undetectable
4p65G-5d9aB:
undetectable
4p65H-5d9aB:
undetectable
4p65B-5d9aB:
4.17
4p65D-5d9aB:
4.17
4p65G-5d9aB:
4.02
4p65H-5d9aB:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 12 GLY C 745
GLN C 744
ALA B 713
PHE B 696
SER B 698
None
1.23A 4pb1A-5d9aC:
undetectable
4pb1A-5d9aC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 12 GLY C 745
GLN C 744
ALA B 713
PHE B 696
SER B 698
None
1.25A 4pd5A-5d9aC:
undetectable
4pd5A-5d9aC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
5 / 12 GLY C 400
ILE C 503
ILE C 402
SER C 381
ALA C 382
None
0.97A 4qtuD-5d9aC:
undetectable
4qtuD-5d9aC:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
3 / 3 THR B  52
ASN B  84
SER B  50
None
0.73A 4tvtA-5d9aB:
undetectable
4tvtA-5d9aB:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 CYH B 169
ILE B 173
PRO B 252
ILE B 256
None
1.01A 4w5oA-5d9aB:
undetectable
4w5oA-5d9aB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 5 ARG A 433
GLY A 436
GLU A 434
SER A 280
None
1.09A 4z3oA-5d9aA:
undetectable
4z3oB-5d9aA:
0.6
4z3oA-5d9aA:
22.75
4z3oB-5d9aA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 CYH B 169
ILE B 173
PRO B 252
ILE B 256
None
0.98A 4z4eA-5d9aB:
undetectable
4z4eA-5d9aB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 7 CYH B 169
ILE B 173
PRO B 252
ILE B 256
None
0.99A 4z4gA-5d9aB:
undetectable
4z4gA-5d9aB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
3 / 3 ASP A 482
ARG A 464
TYR A 462
None
0.79A 5a7mA-5d9aA:
undetectable
5a7mA-5d9aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
3 / 3 ASP A 482
ARG A 464
TYR A 462
None
0.77A 5a7mB-5d9aA:
undetectable
5a7mB-5d9aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 5 SER A 280
ARG A 433
GLY A 436
GLU A 434
None
1.08A 5cdqA-5d9aA:
undetectable
5cdqB-5d9aA:
undetectable
5cdqC-5d9aA:
undetectable
5cdqA-5d9aA:
23.77
5cdqB-5d9aA:
14.70
5cdqC-5d9aA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 5 SER A 280
ARG A 433
GLY A 436
GLU A 434
None
1.07A 5cdqR-5d9aA:
undetectable
5cdqS-5d9aA:
undetectable
5cdqT-5d9aA:
undetectable
5cdqR-5d9aA:
23.77
5cdqS-5d9aA:
14.70
5cdqT-5d9aA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 6 LEU C 536
THR C 532
GLN C 446
MET C 412
None
1.41A 5h8tA-5d9aC:
undetectable
5h8tA-5d9aC:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 8 TRP A 388
GLU A 385
HIS A 261
THR A 272
None
1.42A 5hqaA-5d9aA:
undetectable
5hqaA-5d9aA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
5 / 12 LEU B 238
LEU A 671
LEU A 670
PHE A 642
ALA A 688
None
1.34A 5ieoA-5d9aB:
undetectable
5ieoA-5d9aB:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 6 GLN A 319
CYH A 551
THR A 523
PHE A 525
None
1.25A 5mwyA-5d9aA:
undetectable
5mwyA-5d9aA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
3 / 3 SER B 455
ALA B 454
THR B 463
None
0.74A 5n0xB-5d9aB:
undetectable
5n0xB-5d9aB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT
POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus;
Influenza
C
virus)
5 / 11 GLY C 399
GLY C 501
SER B 290
THR C 383
GLU C 378
None
0.96A 5o96G-5d9aC:
undetectable
5o96G-5d9aC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
5 / 12 PHE C 337
GLY C 377
PHE C 416
ILE C 529
ALA C 531
None
0.98A 5veuH-5d9aC:
undetectable
5veuH-5d9aC:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 8 ALA B 282
THR B 286
THR B 289
ALA C 384
None
0.87A 5x2tI-5d9aB:
undetectable
5x2tJ-5d9aB:
4.0
5x2tK-5d9aB:
undetectable
5x2tL-5d9aB:
undetectable
5x2tI-5d9aB:
11.32
5x2tJ-5d9aB:
10.99
5x2tK-5d9aB:
11.32
5x2tL-5d9aB:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus;
Influenza
C
virus)
4 / 8 PHE B  61
SER A 198
PHE B 403
LEU B 224
None
0.85A 5y2tB-5d9aB:
undetectable
5y2tB-5d9aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 5 ARG B 557
ALA B 558
GLN B 554
ILE B 551
None
1.25A 6f6sA-5d9aB:
undetectable
6f6sB-5d9aB:
undetectable
6f6sA-5d9aB:
7.83
6f6sB-5d9aB:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 TRP C  38
GLY B 247
ALA B 145
LEU B 146
None
0.97A 6fosA-5d9aC:
undetectable
6fosA-5d9aC:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)
5d9a POLYMERASE BASIC
PROTEIN 2
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza
C
virus)
4 / 6 TRP C  38
TRP B 134
ALA B 145
LEU B 146
None
0.92A 6fosA-5d9aC:
undetectable
6fosA-5d9aC:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)
5d9a POLYMERASE ACIDIC
PROTEIN

(Influenza
C
virus)
4 / 8 ASN A  77
PHE A 102
SER A  82
TYR A  83
None
1.12A 6huoC-5d9aA:
undetectable
6huoD-5d9aA:
undetectable
6huoC-5d9aA:
9.24
6huoD-5d9aA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
3 / 3 ILE C 533
THR C 532
PRO C 444
None
0.63A 6ncsA-5d9aC:
undetectable
6ncsA-5d9aC:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5d9a POLYMERASE BASIC
PROTEIN 2

(Influenza
C
virus)
4 / 7 ASP C 421
TYR C 422
TRP C 369
LEU C 463
None
1.17A 6nmfA-5d9aC:
undetectable
6nmfC-5d9aC:
undetectable
6nmfP-5d9aC:
undetectable
6nmfA-5d9aC:
21.05
6nmfC-5d9aC:
15.06
6nmfP-5d9aC:
15.06