SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5db4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 11 GLY A  12
HIS A  19
HIS A  22
GLY A 110
ASP A 112
 None
ATP  A 301 (-4.0A)
ATP  A 301 (-4.0A)
ATP  A 301 (-3.0A)
ATP  A 301 (-3.2A)
 0.87A 1jzsA-5db4A:
undetectable		 1jzsA-5db4A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A  19
GLY A  21
HIS A  22
GLY A 110
ASP A 112
 ATP  A 301 (-4.0A)
ATP  A 301 (-3.7A)
ATP  A 301 (-4.0A)
ATP  A 301 (-3.0A)
ATP  A 301 (-3.2A)
 0.64A 1pg2A-5db4A:
5.4		 1pg2A-5db4A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		4 / 8 ARG A  83
THR A  98
ALA A  99
VAL A  41
 None
 0.76A 2a1hA-5db4A:
undetectable
2a1hB-5db4A:
undetectable		 2a1hA-5db4A:
21.05
2a1hB-5db4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		4 / 5 PHE A  74
PHE A  40
PHE A  15
HIS A  22
 None
None
None
ATP  A 301 (-4.0A)
 1.08A 2lh6A-5db4A:
undetectable		 2lh6A-5db4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A  19
GLY A  21
HIS A  22
GLY A 110
ASP A 112
 ATP  A 301 (-4.0A)
ATP  A 301 (-3.7A)
ATP  A 301 (-4.0A)
ATP  A 301 (-3.0A)
ATP  A 301 (-3.2A)
 0.85A 2x1lA-5db4A:
2.8		 2x1lA-5db4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 12 HIS A  19
GLY A  21
HIS A  22
GLY A 110
ASP A 112
 ATP  A 301 (-4.0A)
ATP  A 301 (-3.7A)
ATP  A 301 (-4.0A)
ATP  A 301 (-3.0A)
ATP  A 301 (-3.2A)
 0.78A 2x1lB-5db4A:
5.9		 2x1lB-5db4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 11 HIS A  19
GLY A  21
HIS A  22
GLY A 110
ASP A 112
 ATP  A 301 (-4.0A)
ATP  A 301 (-3.7A)
ATP  A 301 (-4.0A)
ATP  A 301 (-3.0A)
ATP  A 301 (-3.2A)
 0.84A 2x1lC-5db4A:
5.8		 2x1lC-5db4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 9 LEU A  23
THR A  68
PRO A 187
ILE A  66
LEU A  62
 None
 1.42A 5g48B-5db4A:
undetectable		 5g48B-5db4A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 12 ILE A 108
GLY A  21
SER A 136
GLY A 110
LEU A 114
 None
ATP  A 301 (-3.7A)
None
ATP  A 301 (-3.0A)
None
 0.75A 5i75A-5db4A:
undetectable		 5i75A-5db4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 5 GLY A  13
THR A  14
HIS A  22
SER A 168
SER A 169
 ATP  A 301 (-3.6A)
ATP  A 301 (-4.4A)
ATP  A 301 (-4.0A)
ATP  A 301 (-4.2A)
ATP  A 301 (-3.1A)
 0.50A 6jmjA-5db4A:
16.0		 6jmjA-5db4A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		6 / 7 GLY A  13
THR A  14
PHE A  15
HIS A  22
SER A 168
SER A 169
 ATP  A 301 (-3.6A)
ATP  A 301 (-4.4A)
None
ATP  A 301 (-4.0A)
ATP  A 301 (-4.2A)
ATP  A 301 (-3.1A)
 0.54A 6jnhA-5db4A:
15.9		 6jnhA-5db4A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5db4 NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE
(Mycobacteroides
abscessus) 		5 / 6 GLY A  13
THR A  14
HIS A  22
SER A 168
SER A 169
 ATP  A 301 (-3.6A)
ATP  A 301 (-4.4A)
ATP  A 301 (-4.0A)
ATP  A 301 (-4.2A)
ATP  A 301 (-3.1A)
 0.50A 6jogA-5db4A:
16.0		 6jogA-5db4A:
27.06