SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNN_H_ESTH350_1
(MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN
MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN KAPPA
CHAIN)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		5 / 10 GLU A 178
LYS A 176
TYR A 199
LEU A 171
TYR A 192
 None
 1.34A 1jnnH-5dbkA:
undetectable
1jnnL-5dbkA:
undetectable		 1jnnH-5dbkA:
17.07
1jnnL-5dbkA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 TYR A 192
GLY A 190
VAL A  84
ALA A 196
LEU A 175
 None
 1.34A 1kiaD-5dbkA:
undetectable		 1kiaD-5dbkA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 299
ALA A 270
LEU A 273
ASN A 275
MET A 276
 None
 1.17A 1sa1A-5dbkA:
undetectable
1sa1B-5dbkA:
undetectable		 1sa1A-5dbkA:
22.34
1sa1B-5dbkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_1
(HYPOTHETICAL PROTEIN)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		4 / 4 GLU A  70
ASP A  77
ASP A 107
TYR A 113
 None
 1.06A 2yvlA-5dbkA:
undetectable		 2yvlA-5dbkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 ARG A 120
LEU A 117
ARG A  93
GLU A  78
GLU A  97
 None
 1.33A 3ua5A-5dbkA:
undetectable		 3ua5A-5dbkA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		5 / 11 LEU A 117
ARG A  93
GLU A  78
MET A 102
GLU A  97
 None
 1.36A 3ua5A-5dbkA:
undetectable		 3ua5A-5dbkA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A 299
LEU A 273
ASN A 275
MET A 276
ALA A 259
 None
 1.13A 3ut5D-5dbkA:
undetectable		 3ut5D-5dbkA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		3 / 3 LEU A 106
MET A 102
ASP A  71
 None
 0.75A 3v5wA-5dbkA:
2.2		 3v5wA-5dbkA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		5 / 12 LEU A  83
TRP A  79
VAL A  91
LEU A 131
LEU A 122
 None
 1.38A 4yvpB-5dbkA:
undetectable		 4yvpB-5dbkA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		3 / 4 ARG A 220
GLY A 218
GLU A 217
 None
 0.49A 4z2dB-5dbkA:
1.4
4z2dC-5dbkA:
undetectable		 4z2dB-5dbkA:
22.10
4z2dC-5dbkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 GLU A 370
LYS A 366
GLU A 405
PHE A 397
 None
 1.31A 5onlA-5dbkA:
undetectable		 5onlA-5dbkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_B_ADNB503_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 LEU A  76
VAL A  72
GLU A 101
LEU A  98
 None
 1.03A 5xooB-5dbkA:
undetectable		 5xooB-5dbkA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		4 / 6 GLU A 326
LEU A 330
LYS A 290
LEU A 294
 None
 1.09A 5yvnA-5dbkA:
3.8		 5yvnA-5dbkA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 5dbk TRANSCRIPTIONAL
REGULATOR/TPR DOMAIN
PROTEIN
(Bacillus
thuringiensis) 		4 / 5 GLU A 370
LYS A 366
GLU A 405
PHE A 397
 None
 1.30A 6hrjA-5dbkA:
undetectable		 6hrjA-5dbkA:
21.04