SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dbo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 VAL A 162
GLY A 163
MET A 166
LEU A 216
MET A 222
 None
 1.39A 1a27A-5dboA:
5.0		 1a27A-5dboA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ARG A 291
ASN A 396
ILE A 395
PHE A 169
ILE A 175
 None
 1.44A 1q8jA-5dboA:
undetectable		 1q8jA-5dboA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 7 ASP A 427
TYR A 433
MET A 379
ASP A 376
 None
 1.33A 1t03A-5dboA:
undetectable		 1t03A-5dboA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 357
VAL A 437
GLY A 366
VAL A 388
VAL A 390
 None
 1.04A 2nnpB-5dboA:
undetectable		 2nnpB-5dboA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 11 LEU A 299
LEU A 300
LEU A 325
GLY A 358
LEU A 391
 None
 1.22A 3hm1B-5dboA:
undetectable		 3hm1B-5dboA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 330
VAL A 295
THR A 288
 None
 0.77A 3k4vD-5dboA:
undetectable		 3k4vD-5dboA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ILE A 334
VAL A 311
ILE A 286
ASN A 281
ILE A 280
 None
 1.14A 3kpdB-5dboA:
undetectable		 3kpdB-5dboA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 9 GLY A 358
GLU A 360
LEU A 294
LEU A 391
ILE A 272
 None
 1.42A 3nbqA-5dboA:
undetectable		 3nbqA-5dboA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		3 / 3 ARG A 330
VAL A 295
THR A 288
 None
 0.73A 3ndtA-5dboA:
undetectable		 3ndtA-5dboA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 LEU A 368
GLU A 269
GLY A 358
LEU A 391
ALA A 268
 None
 1.23A 3ou6C-5dboA:
4.5		 3ou6C-5dboA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		4 / 5 ASP A 420
ILE A 133
PRO A 134
PHE A 137
 None
 0.96A 3s3vA-5dboA:
undetectable		 3s3vA-5dboA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 12 ALA A 352
GLY A 283
ASN A 281
ILE A 334
LEU A 299
 None
 1.04A 4n48B-5dboA:
2.2		 4n48B-5dboA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN
(Chaetomium
thermophilum) 		5 / 8 ILE A 286
VAL A 295
THR A 429
ALA A 378
THR A 374
 None
 1.17A 5og9A-5dboA:
2.2		 5og9A-5dboA:
22.14