SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Streptococcus
suis) 		4 / 4 LYS A 110
LEU A 106
ALA A 145
LEU A 141
 None
 1.28A 1f86B-5dbtA:
undetectable		 1f86B-5dbtA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Streptococcus
suis) 		5 / 12 ILE A  92
VAL A 123
ALA A 199
MET A 169
SER A 182
 None
 1.31A 1nbhA-5dbtA:
2.9		 1nbhA-5dbtA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Streptococcus
suis) 		5 / 12 ILE A  92
VAL A 123
ALA A 199
MET A 169
SER A 182
 None
 1.31A 1nbhC-5dbtA:
undetectable		 1nbhC-5dbtA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Streptococcus
suis) 		5 / 12 ILE A  92
VAL A 123
ALA A 199
MET A 169
SER A 182
 None
 1.30A 1nbhD-5dbtA:
undetectable		 1nbhD-5dbtA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Streptococcus
suis) 		4 / 7 PHE A  63
THR A  10
GLY A 183
THR A 152
 None
 0.93A 2a1mA-5dbtA:
undetectable		 2a1mA-5dbtA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Streptococcus
suis) 		5 / 12 GLY A  84
ILE A  81
ASP A  79
ALA A  80
VAL A  43
 None
 1.15A 3nvkI-5dbtA:
undetectable		 3nvkI-5dbtA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE
(Streptococcus
suis) 		4 / 4 THR A 152
GLY A 184
ASP A 190
SER A 153
 None
 1.38A 4rfqA-5dbtA:
undetectable		 4rfqA-5dbtA:
23.21