SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dbx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_B_ESTB2_1
(ESTROGEN RECEPTOR)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 10 MET A 268
ALA A 275
LEU A 278
ILE A 220
LEU A 189
None
1.40A 1a52B-5dbxA:
undetectable
1a52B-5dbxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 ILE A  81
VAL A  89
ALA A 102
LEU A 152
GLY A 156
LEU A 211
ANP  A 401 ( 4.1A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
None
0.71A 2y7jA-5dbxA:
23.4
2y7jA-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 10 ILE A  81
ALA A 102
LEU A 152
GLY A 156
ASP A 160
LEU A 211
ANP  A 401 ( 4.1A)
ANP  A 401 ( 4.0A)
None
None
None
None
0.84A 2y7jC-5dbxA:
23.5
2y7jC-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_C_B49C1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 10 ILE A  81
VAL A  89
ALA A 102
LEU A 152
ASP A 160
LEU A 211
ANP  A 401 ( 4.1A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
None
0.75A 2y7jC-5dbxA:
23.5
2y7jC-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 10 ILE A  81
VAL A  89
ALA A 102
LEU A 152
ASP A 160
LEU A 211
ANP  A 401 ( 4.1A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
None
0.87A 2y7jD-5dbxA:
23.5
2y7jD-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C7Q_A_XINA1172_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 GLY A  82
ALA A 102
LYS A 104
VAL A 134
GLY A 156
LEU A 211
ANP  A 401 ( 3.9A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
None
0.55A 3c7qA-5dbxA:
20.4
3c7qA-5dbxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 12 ILE A 210
GLU A 277
ILE A 162
LEU A 362
ILE A 184
None
1.09A 3cd2A-5dbxA:
undetectable
3cd2A-5dbxA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 12 GLY A 208
LEU A 205
ASP A 160
LEU A 278
LEU A 176
None
1.10A 3cjtG-5dbxA:
undetectable
3cjtG-5dbxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
8 / 12 GLY A  82
GLY A  84
VAL A  89
ALA A 102
VAL A 134
MET A 150
LEU A 153
LEU A 211
ANP  A 401 ( 3.9A)
ANP  A 401 (-3.3A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
ANP  A 401 (-4.0A)
ANP  A 401 (-4.1A)
None
0.73A 3fupB-5dbxA:
20.0
3fupB-5dbxA:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 12 ALA A 352
LYS A 347
LEU A 328
LEU A 325
LEU A 344
None
CAS  A 346 ( 2.8A)
None
CAS  A 346 ( 4.8A)
None
1.03A 3hecA-5dbxA:
19.2
3hecA-5dbxA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
4 / 8 VAL A 133
VAL A 134
LEU A 211
ILE A 220
None
0.66A 3wzeA-5dbxA:
20.1
3wzeA-5dbxA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
7 / 12 GLY A  82
VAL A  89
ALA A 102
LYS A 104
LEU A 148
GLY A 156
LEU A 211
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
None
0.46A 4ifgA-5dbxA:
23.2
4ifgA-5dbxA:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
3 / 3 VAL A 166
GLY A 169
LYS A 172
None
0.76A 4k50I-5dbxA:
undetectable
4k50I-5dbxA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
4 / 7 ARG A  72
ARG A 105
SER A 154
VAL A  80
None
1.26A 4klrA-5dbxA:
undetectable
4klrA-5dbxA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 GLY A  82
VAL A  89
ALA A 102
MET A 150
LEU A 153
LEU A 211
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
ANP  A 401 (-4.1A)
None
0.58A 4qmzA-5dbxA:
27.8
4qmzA-5dbxA:
43.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 ILE A  81
GLY A  82
VAL A  89
ALA A 102
LEU A 153
LEU A 211
ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.1A)
None
0.76A 4qmzA-5dbxA:
27.8
4qmzA-5dbxA:
43.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 VAL A  89
ALA A 102
LEU A 195
HIS A 202
ALA A 221
GLY A 224
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
MG  A 402 ( 4.6A)
None
0.89A 4v04A-5dbxA:
20.7
4v04A-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
4 / 7 PHE A 349
THR A 274
LEU A 205
MET A 268
None
0.81A 4zdzA-5dbxA:
undetectable
4zdzA-5dbxA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
4 / 6 GLU A 214
GLY A 213
GLY A 216
ASP A 215
None
0.95A 5a06D-5dbxA:
undetectable
5a06D-5dbxA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 ILE A  81
GLY A  82
VAL A  89
ALA A 102
VAL A 134
LEU A 211
ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
0.67A 5l2iA-5dbxA:
5.2
5l2iA-5dbxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 ILE A  81
GLY A  82
VAL A  89
ALA A 102
VAL A 134
LEU A 211
ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
0.96A 5l2tA-5dbxA:
21.4
5l2tA-5dbxA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 9 ILE A  81
GLY A  82
VAL A  89
ALA A 102
MET A 150
ANP  A 401 ( 4.1A)
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
0.56A 5lw1B-5dbxA:
18.8
5lw1B-5dbxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 10 GLY A  82
VAL A  89
ALA A 102
MET A 150
LEU A 152
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
None
0.42A 5lw1E-5dbxA:
18.4
5lw1E-5dbxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 9 GLY A  82
VAL A  89
ALA A 102
MET A 150
LEU A 152
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-4.0A)
None
0.42A 5lw1H-5dbxA:
18.8
5lw1H-5dbxA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 10 ILE A 181
ILE A 180
ILE A 161
ILE A 162
ILE A 165
None
0.85A 5murE-5dbxA:
undetectable
5murE-5dbxA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
6 / 12 GLY A  82
VAL A  89
ALA A 102
LYS A 104
LEU A 148
LEU A 211
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
0.63A 5yu9A-5dbxA:
22.0
5yu9A-5dbxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
7 / 12 GLY A  82
VAL A  89
ALA A 102
LYS A 104
LEU A 148
ASP A 160
LEU A 211
ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
None
0.95A 5yu9B-5dbxA:
22.2
5yu9B-5dbxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 12 VAL A  89
ALA A 102
LYS A 104
LEU A 148
ASP A 160
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
0.70A 5yu9C-5dbxA:
22.0
5yu9C-5dbxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus
musculus)
5 / 12 LEU A 330
ALA A 279
PHE A 322
LEU A 326
LEU A 185
None
1.10A 6ew0G-5dbxA:
undetectable
6ew0G-5dbxA:
14.76