SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VM1_A_TAZA504_1 (BETA-LACTAMASE SHV-1)	5dc4	AS25 MONOBODY (Homo sapiens)	3 / 3	ASP B 32 TYR B 77 GLU B 51	None	0.85A	1vm1A-5dc4B: undetectable	1vm1A-5dc4B: 18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOQ_B_ROFB501_0 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5dc4	AS25 MONOBODY (Homo sapiens)	5 / 12	PRO B 27 TRP B 24 THR B 8 ILE B 89 SER B 4	None	1.35A	1xoqB-5dc4B: undetectable	1xoqB-5dc4B: 15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VRJ_A_1KXA301_1 (HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN 10-MER PEPTIDE)	5dc4	AS25 MONOBODY (Homo sapiens)	5 / 12	ILE B 72 VAL B 74 TYR B 34 TYR B 38 ILE B 61	None	1.08A	3vrjA-5dc4B: 4.9 3vrjC-5dc4B: undetectable	3vrjA-5dc4B: 15.69 3vrjC-5dc4B: 7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_D_EY4D500_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	5dc4	AS25 MONOBODY (Homo sapiens)	4 / 7	ILE B 72 VAL B 12 ALA B 15 THR B 16	None	0.96A	6cduC-5dc4B: 1.7 6cduD-5dc4B: undetectable	6cduC-5dc4B: 15.74 6cduD-5dc4B: 15.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1VM1_A_TAZA504_1","BETA-LACTAMASE SHV-1","5dc4","AS25 MONOBODY","Homo sapiens",3,"ASP B  32;TYR B  77;GLU B  51","None","0.85A","1vm1A-5dc4B:undetectable","1vm1A-5dc4B:18.07"],["1XOQ_B_ROFB501_0","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","5dc4","AS25 MONOBODY","Homo sapiens",5,"PRO B  27;TRP B  24;THR B   8;ILE B  89;SER B   4","None","1.35A","1xoqB-5dc4B:undetectable","1xoqB-5dc4B:15.16"],["3VRJ_A_1KXA301_1","HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN;10-MER PEPTIDE","5dc4","AS25 MONOBODY","Homo sapiens",5,"ILE B  72;VAL B  74;TYR B  34;TYR B  38;ILE B  61","None","1.08A","3vrjA-5dc4B:4.9;3vrjC-5dc4B:undetectable","3vrjA-5dc4B:15.69;3vrjC-5dc4B:7.87"],["6CDU_D_EY4D500_0","CHIMERIC ALPHA1GABAA RECEPTOR","5dc4","AS25 MONOBODY","Homo sapiens",4,"ILE B  72;VAL B  12;ALA B  15;THR B  16","None","0.96A","6cduC-5dc4B:1.7;6cduD-5dc4B:undetectable","6cduC-5dc4B:15.74;6cduD-5dc4B:15.74"]]