SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dcz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 7 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.3A)
 0.16A 1dmaA-5dczA:
6.1		 1dmaA-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 7 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.75A 1dmaA-5dczA:
6.1		 1dmaA-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		5 / 6 HIS A1031
GLY A1032
TYR A1060
ALA A1062
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-3.3A)
 0.35A 1dmaB-5dczA:
5.5		 1dmaB-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 6 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.55A 1dmaB-5dczA:
5.5		 1dmaB-5dczA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 7 ALA A1135
ARG A 980
TYR A1050
TYR A1060
 None
PO4  A1202 (-4.9A)
59B  A1203 ( 4.3A)
59B  A1203 (-4.3A)
 1.20A 2ajvH-5dczA:
undetectable
2ajvL-5dczA:
undetectable		 2ajvH-5dczA:
21.54
2ajvL-5dczA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		3 / 3 LEU A1096
ARG A1094
ILE A1153
 None
 0.58A 2xn5B-5dczA:
undetectable		 2xn5B-5dczA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5dcz TANKYRASE-2
(Homo
sapiens) 		5 / 12 TYR A1071
ILE A1051
GLY A1052
GLY A1053
ILE A1075
 59B  A1203 (-3.3A)
None
None
None
59B  A1203 (-4.8A)
 1.04A 3jayA-5dczA:
undetectable		 3jayA-5dczA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 8 GLY A1058
ILE A1039
PHE A1098
PHE A1061
 None
 1.02A 3ko0K-5dczA:
undetectable
3ko0S-5dczA:
undetectable		 3ko0K-5dczA:
19.49
3ko0S-5dczA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 5 GLU A1026
LEU A1103
HIS A1023
GLY A1104
 None
 1.28A 3pp1A-5dczA:
undetectable		 3pp1A-5dczA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 5 PHE A1098
ILE A 956
LEU A 955
LYS A 999
 None
 1.17A 3sueC-5dczA:
undetectable		 3sueC-5dczA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		8 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.23A 3u9hA-5dczA:
37.4		 3u9hA-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		8 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.23A 3u9hB-5dczA:
37.2		 3u9hB-5dczA:
96.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 6 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.3A)
 0.29A 4ae1A-5dczA:
6.8		 4ae1A-5dczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 6 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.77A 4ae1A-5dczA:
6.8		 4ae1A-5dczA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 5 HIS A1031
GLY A1032
TYR A1060
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.3A)
 0.31A 4ae1B-5dczA:
5.0		 4ae1B-5dczA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5dcz TANKYRASE-2
(Homo
sapiens) 		4 / 5 HIS A1031
GLY A1032
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.76A 4ae1B-5dczA:
5.0		 4ae1B-5dczA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		8 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.21A 4bjcA-5dczA:
34.5		 4bjcA-5dczA:
96.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5dcz TANKYRASE-2
(Homo
sapiens) 		3 / 3 TYR A1009
THR A1102
GLU A1150
 None
 0.72A 4df3A-5dczA:
undetectable		 4df3A-5dczA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5dcz TANKYRASE-2
(Homo
sapiens) 		3 / 3 TYR A1009
THR A1102
GLU A1150
 None
 0.69A 4df3B-5dczA:
undetectable		 4df3B-5dczA:
20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 7 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.90A 4hyfA-5dczA:
32.9		 4hyfA-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 7 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.44A 4hyfA-5dczA:
32.9		 4hyfA-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.90A 4hyfB-5dczA:
32.9		 4hyfB-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		7 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.50A 4hyfB-5dczA:
32.9		 4hyfB-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		5 / 8 HIS A1031
GLY A1032
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.78A 4hyfC-5dczA:
32.4		 4hyfC-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.46A 4hyfC-5dczA:
32.4		 4hyfC-5dczA:
96.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 8 HIS A1031
GLY A1032
TYR A1060
LYS A1067
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 1.08A 4hyfC-5dczA:
32.4		 4hyfC-5dczA:
96.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.91A 4rv6A-5dczA:
19.4		 4rv6A-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
 1.11A 4rv6A-5dczA:
19.4		 4rv6A-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_A_RPBA1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.43A 4rv6A-5dczA:
19.4		 4rv6A-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
ALA A1062
SER A1068
TYR A1071
GLU A1138
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
59B  A1203 (-3.7A)
 0.91A 4rv6B-5dczA:
19.4		 4rv6B-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
LYS A1067
SER A1068
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
PO4  A1202 (-2.7A)
59B  A1203 (-2.8A)
 1.11A 4rv6B-5dczA:
19.4		 4rv6B-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RV6_B_RPBB1103_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 11 HIS A1031
GLY A1032
TYR A1060
ALA A1062
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-4.1A)
59B  A1203 (-4.3A)
59B  A1203 (-3.5A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.42A 4rv6B-5dczA:
19.4		 4rv6B-5dczA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HA9_B_TP0B406_1
(POLY [ADP-RIBOSE]
POLYMERASE 1)		 5dcz TANKYRASE-2
(Homo
sapiens) 		6 / 9 HIS A1031
SER A1033
ILE A1039
TYR A1060
SER A1068
TYR A1071
 59B  A1203 (-4.1A)
59B  A1203 (-3.5A)
None
59B  A1203 (-4.3A)
59B  A1203 (-2.8A)
59B  A1203 (-3.3A)
 0.65A 5ha9B-5dczA:
17.4		 5ha9B-5dczA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5dcz TANKYRASE-2
(Homo
sapiens) 		3 / 3 ARG A1143
HIS A1123
ARG A1012
 None
 1.15A 5iaoC-5dczA:
undetectable		 5iaoC-5dczA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 5dcz TANKYRASE-2
(Homo
sapiens) 		3 / 3 ARG A1143
HIS A1123
ARG A1012
 None
 1.11A 5iaoF-5dczA:
undetectable		 5iaoF-5dczA:
18.33