SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.68A 1ictD-5dd5L:
3.8		 1ictD-5dd5L:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.84A 2aojA-5dd5L:
undetectable		 2aojA-5dd5L:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		4 / 8 LYS L 126
GLY L 128
ASP L 185
THR L 180
 None
 0.99A 2aouA-5dd5L:
undetectable		 2aouA-5dd5L:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		5 / 9 THR H  67
LEU H  80
VAL H  20
ASP H  86
VAL H 109
 None
 1.22A 2l8mA-5dd5H:
undetectable		 2l8mA-5dd5H:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		4 / 7 TYR H  91
TYR L  36
PRO L  44
TYR L  87
 None
 0.42A 2oldA-5dd5H:
13.0
2oldB-5dd5H:
16.9		 2oldA-5dd5H:
31.65
2oldB-5dd5H:
31.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		4 / 7 TYR L  36
PRO L  44
TYR L  87
TYR H  91
 None
 0.39A 2oldA-5dd5L:
16.1
2oldB-5dd5L:
20.0		 2oldA-5dd5L:
42.11
2oldB-5dd5L:
42.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		3 / 3 GLN L 124
THR L 129
LEU H 175
 None
 0.69A 3ondA-5dd5L:
undetectable		 3ondA-5dd5L:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		3 / 3 GLN L 124
THR L 129
LEU H 175
 None
 0.71A 3ondB-5dd5L:
undetectable		 3ondB-5dd5L:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		5 / 12 TYR H  52
ILE H  37
TYR H 100
PHE H  78
ILE H  51
 None
 1.49A 3q5pA-5dd5H:
undetectable		 3q5pA-5dd5H:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		4 / 5 LEU L 179
PRO L 120
VAL L 132
ASP L 185
 None
 1.16A 3ufnA-5dd5L:
undetectable
3ufnB-5dd5L:
undetectable		 3ufnA-5dd5L:
19.14
3ufnB-5dd5L:
19.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 TRP H  33
PHE H 100
GLN L  89
GLN L  90
PRO L  96
 None
 0.87A 4uilH-5dd5H:
18.6
4uilL-5dd5H:
12.2		 4uilH-5dd5H:
51.93
4uilL-5dd5H:
24.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 TRP H  33
TRP H  47
THR H  50
PHE H 100
PRO L  96
 None
 0.83A 4uinH-5dd5H:
24.7
4uinL-5dd5H:
17.2		 4uinH-5dd5H:
51.28
4uinL-5dd5H:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.88A 5e9qA-5dd5H:
undetectable		 5e9qA-5dd5H:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.83A 5ec8A-5dd5H:
undetectable		 5ec8A-5dd5H:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.92A 5ehiA-5dd5H:
undetectable		 5ehiA-5dd5H:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.95A 5eiwA-5dd5H:
undetectable		 5eiwA-5dd5H:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.88A 5ekxA-5dd5H:
undetectable		 5ekxA-5dd5H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.86A 5ekxB-5dd5H:
undetectable		 5ekxB-5dd5H:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta) 		4 / 8 THR L  74
SER L  63
THR L  72
SER L  65
 None
 0.94A 5l4eA-5dd5L:
undetectable
5l4eB-5dd5L:
undetectable
5l4eC-5dd5L:
undetectable
5l4eD-5dd5L:
undetectable
5l4eE-5dd5L:
undetectable		 5l4eA-5dd5L:
19.94
5l4eB-5dd5L:
19.94
5l4eC-5dd5L:
19.94
5l4eD-5dd5L:
19.94
5l4eE-5dd5L:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.90A 5m5bA-5dd5H:
undetectable		 5m5bA-5dd5H:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		3 / 3 SER L  30
SER L  28
PHE H 100
 None
 0.83A 5mugA-5dd5L:
undetectable		 5mugA-5dd5L:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.85A 5njvA-5dd5H:
undetectable		 5njvA-5dd5H:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.86A 5njvB-5dd5H:
undetectable		 5njvB-5dd5H:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)		 5dd5 ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
ANTI-HIV ANTIBODY
DH570.9 FAB HEAVY
CHAIN
(Macaca
mulatta;
Macaca
mulatta) 		5 / 12 GLY H  35
GLY H 106
GLY H 104
LYS L  42
ILE H  89
 None
 0.82A 5wz2C-5dd5H:
undetectable		 5wz2C-5dd5H:
22.87