SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ddb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 299
GLU A 288
ARG A 330
ILE A 306
GLY A 305
 None
 1.26A 1g50B-5ddbA:
undetectable		 1g50B-5ddbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5ddb MENIN
(Homo
sapiens) 		5 / 11 LEU A 299
GLU A 288
ARG A 330
ILE A 306
GLY A 305
 None
 1.26A 1g50C-5ddbA:
2.2		 1g50C-5ddbA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 105
PHE A 146
ALA A 160
ALA A 164
LEU A 117
 None
 1.37A 1kt5A-5ddbA:
undetectable		 1kt5A-5ddbA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5ddb MENIN
(Homo
sapiens) 		4 / 6 ALA A  25
GLU A  26
LEU A  36
LEU A  83
 None
 0.92A 1mt1D-5ddbA:
undetectable
1mt1E-5ddbA:
undetectable		 1mt1D-5ddbA:
12.81
1mt1E-5ddbA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5ddb MENIN
(Homo
sapiens) 		4 / 6 ALA A  25
LEU A  13
GLU A  26
LEU A  36
 None
 1.02A 1mt1D-5ddbA:
undetectable
1mt1E-5ddbA:
undetectable		 1mt1D-5ddbA:
12.81
1mt1E-5ddbA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5ddb MENIN
(Homo
sapiens) 		5 / 11 PHE A 146
GLY A  99
VAL A 121
ILE A 125
VAL A 124
 None
 1.20A 1phgA-5ddbA:
undetectable		 1phgA-5ddbA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 283
ASN A 282
LEU A 280
ALA A 279
LEU A 263
 None
 1.09A 1ya3C-5ddbA:
undetectable		 1ya3C-5ddbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 286
LEU A 283
ASN A 282
LEU A 280
ALA A 279
 None
 0.96A 1ya3C-5ddbA:
undetectable		 1ya3C-5ddbA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ddb MENIN
(Homo
sapiens) 		4 / 5 GLY A  42
GLN A 141
VAL A  50
SER A 145
 None
 1.24A 1zzuB-5ddbA:
undetectable		 1zzuB-5ddbA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A  41
LEU A 263
ILE A  16
GLU A 255
PHE A  78
 None
 1.06A 2weyA-5ddbA:
undetectable		 2weyA-5ddbA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5ddb MENIN
(Homo
sapiens) 		4 / 7 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 1.03A 3asnP-5ddbA:
1.9
3asnW-5ddbA:
undetectable		 3asnP-5ddbA:
17.43
3asnW-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5ddb MENIN
(Homo
sapiens) 		4 / 7 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 1.03A 3asoP-5ddbA:
undetectable
3asoW-5ddbA:
undetectable		 3asoP-5ddbA:
17.43
3asoW-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 GLY A 163
CYH A 165
LEU A 103
VAL A 101
ILE A  97
 None
 1.09A 3g9eA-5ddbA:
undetectable		 3g9eA-5ddbA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5ddb MENIN
(Homo
sapiens) 		5 / 11 ALA A 158
ALA A 182
VAL A 196
ALA A 164
GLY A 163
 None
59Q  A 601 (-3.7A)
None
None
None
 0.89A 3mg0K-5ddbA:
undetectable
3mg0L-5ddbA:
undetectable		 3mg0K-5ddbA:
17.41
3mg0L-5ddbA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SNF_A_ACTA110_0
(PROTEIN P-30)		 5ddb MENIN
(Homo
sapiens) 		4 / 5 ILE A 318
THR A 344
THR A 346
PHE A 364
 None
 1.22A 3snfA-5ddbA:
undetectable		 3snfA-5ddbA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5ddb MENIN
(Homo
sapiens) 		4 / 5 LEU A 286
LEU A 289
LEU A 254
SER A 253
 None
 0.91A 3vhuA-5ddbA:
undetectable		 3vhuA-5ddbA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ddb MENIN
(Homo
sapiens) 		4 / 6 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 1.02A 3wg7C-5ddbA:
2.5
3wg7J-5ddbA:
undetectable		 3wg7C-5ddbA:
17.43
3wg7J-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 286
LEU A 283
ASN A 282
LEU A 280
ALA A 279
 None
 1.00A 4fn9A-5ddbA:
undetectable		 4fn9A-5ddbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A  27
ALA A  24
LEU A 263
LEU A 259
LEU A  10
 None
 1.17A 4j24D-5ddbA:
undetectable		 4j24D-5ddbA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 286
LEU A 283
ASN A 282
LEU A 280
ALA A 279
 None
 0.97A 4ltwA-5ddbA:
undetectable		 4ltwA-5ddbA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5ddb MENIN
(Homo
sapiens) 		4 / 5 TYR A 361
LEU A 413
THR A 344
MET A 322
 PG4  A 604 ( 4.6A)
None
None
59Q  A 601 (-4.4A)
 1.48A 4mbsB-5ddbA:
undetectable		 4mbsB-5ddbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 TYR A 222
SER A 178
THR A 210
THR A 193
ALA A 194
 None
None
None
DMS  A 612 ( 4.7A)
None
 1.47A 4u15A-5ddbA:
undetectable		 4u15A-5ddbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ddb MENIN
(Homo
sapiens) 		3 / 3 ARG A 415
ILE A 420
PHE A 416
 None
 0.76A 5kirA-5ddbA:
0.0		 5kirA-5ddbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 301
GLY A 281
GLU A 290
LEU A 289
GLU A 288
 None
 1.27A 5nwvA-5ddbA:
undetectable		 5nwvA-5ddbA:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 PHE A 146
PHE A  93
ALA A 242
ILE A 243
GLY A  42
 None
None
DMS  A 607 ( 3.8A)
None
None
 0.95A 5veuB-5ddbA:
undetectable		 5veuB-5ddbA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ddb MENIN
(Homo
sapiens) 		4 / 5 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 1.04A 5x19C-5ddbA:
1.9
5x19J-5ddbA:
undetectable		 5x19C-5ddbA:
17.43
5x19J-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ddb MENIN
(Homo
sapiens) 		4 / 7 LEU A 551
PHE A 553
LEU A 414
PHE A 410
 None
 0.98A 5x1fP-5ddbA:
1.9
5x1fW-5ddbA:
undetectable		 5x1fP-5ddbA:
17.43
5x1fW-5ddbA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5ddb MENIN
(Homo
sapiens) 		5 / 12 LEU A 177
GLY A 156
ALA A 182
ASP A 153
PHE A 146
 59Q  A 601 (-3.8A)
None
59Q  A 601 (-3.7A)
None
None
 1.28A 5x6yC-5ddbA:
undetectable		 5x6yC-5ddbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5ddb MENIN
(Homo
sapiens) 		4 / 4 PHE A 447
LEU A 579
LEU A 414
VAL A 441
 None
 1.21A 5xxiA-5ddbA:
undetectable		 5xxiA-5ddbA:
22.33