SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 6 LEU A 237
ASP A 240
LEU A 312
HIS A 208
 None
 1.16A 1errB-5ddsA:
undetectable		 1errB-5ddsA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 SER A 507
PHE A 466
LEU A 467
VAL A 475
PHE A 487
 None
 1.46A 1q23D-5ddsA:
undetectable
1q23E-5ddsA:
undetectable		 1q23D-5ddsA:
16.99
1q23E-5ddsA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 10 SER A 507
PHE A 466
LEU A 467
VAL A 475
PHE A 487
 None
 1.41A 1q23E-5ddsA:
undetectable		 1q23E-5ddsA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 8 HIS A  64
PRO A  65
SER A 490
THR A 494
 GOL  A 602 (-4.2A)
GOL  A 602 ( 4.7A)
None
None
 1.07A 1rg9B-5ddsA:
undetectable		 1rg9B-5ddsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 8 HIS A  64
PRO A  65
SER A 490
THR A 494
 GOL  A 602 (-4.2A)
GOL  A 602 ( 4.7A)
None
None
 1.09A 1rg9C-5ddsA:
undetectable		 1rg9C-5ddsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 8 HIS A  64
PRO A  65
SER A 490
THR A 494
 GOL  A 602 (-4.2A)
GOL  A 602 ( 4.7A)
None
None
 1.08A 1rg9D-5ddsA:
undetectable		 1rg9D-5ddsA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 8 PHE A  60
TYR A 492
LEU A 491
GLY A 322
 None
GOL  A 602 ( 4.0A)
None
None
 1.01A 1rmtC-5ddsA:
2.4		 1rmtC-5ddsA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 GLY A 320
ALA A 345
ILE A 346
THR A 341
VAL A 314
 None
 1.38A 1vq1A-5ddsA:
2.5		 1vq1A-5ddsA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 8 ARG A 104
PHE A 328
LEU A 342
LEU A 389
 None
 1.01A 2bfpA-5ddsA:
undetectable		 2bfpA-5ddsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 8 ARG A 104
PHE A 328
LEU A 342
LEU A 389
 None
 1.03A 2bfpD-5ddsA:
undetectable		 2bfpD-5ddsA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 11 ILE A 321
GLY A 329
LEU A  98
GLY A 322
GLU A 105
 None
 1.31A 2fn1A-5ddsA:
undetectable		 2fn1A-5ddsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 LEU A 171
VAL A 269
VAL A 182
LEU A 157
LEU A 150
 None
 1.35A 2hc4A-5ddsA:
undetectable		 2hc4A-5ddsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 LEU A 237
ASP A 240
LEU A 312
HIS A 208
 None
 1.16A 2jfaA-5ddsA:
undetectable		 2jfaA-5ddsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_B_SAMB500_0
(HYPOTHETICAL PROTEIN)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 6 ASP A 315
VAL A 317
PHE A 280
THR A 218
 PLP  A 601 (-3.0A)
PLP  A 601 ( 4.3A)
None
None
 1.20A 2q6oB-5ddsA:
undetectable		 2q6oB-5ddsA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 11 GLU A 105
ILE A 321
GLY A 322
GLY A 325
LEU A  98
 None
 0.91A 2qmmA-5ddsA:
undetectable
2qmmB-5ddsA:
undetectable		 2qmmA-5ddsA:
18.15
2qmmB-5ddsA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 LEU A 237
ASP A 240
LEU A 312
HIS A 208
 None
 1.18A 2qxsA-5ddsA:
undetectable		 2qxsA-5ddsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 LEU A 237
ASP A 240
LEU A 312
HIS A 208
 None
 1.19A 2qxsB-5ddsA:
undetectable		 2qxsB-5ddsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 SER A 482
LEU A 512
ALA A 464
ARG A 418
GLU A 438
 None
 1.17A 2v0mC-5ddsA:
undetectable		 2v0mC-5ddsA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		3 / 3 GLU A 393
GLN A 401
ARG A 404
 None
 0.75A 2w3bB-5ddsA:
2.1		 2w3bB-5ddsA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 ILE A 101
LEU A 342
ALA A 345
ILE A 346
VAL A 392
 None
 0.98A 3b2rA-5ddsA:
undetectable		 3b2rA-5ddsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 11 ILE A 101
LEU A 342
ALA A 345
ILE A 346
VAL A 392
 None
 0.96A 3b2rB-5ddsA:
undetectable		 3b2rB-5ddsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 7 GLN A 318
GLY A 289
GLY A 286
ALA A 436
 PLP  A 601 (-3.4A)
None
None
None
 0.72A 3fpjB-5ddsA:
undetectable		 3fpjB-5ddsA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 6 GLN A 408
LEU A 410
GLU A 411
LEU A 435
 None
 0.60A 3h5gA-5ddsA:
undetectable
3h5gC-5ddsA:
undetectable		 3h5gA-5ddsA:
5.02
3h5gC-5ddsA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 6 LEU A 435
GLN A 408
LEU A 410
GLU A 411
 None
 1.00A 3h5gB-5ddsA:
undetectable
3h5gC-5ddsA:
undetectable		 3h5gB-5ddsA:
5.02
3h5gC-5ddsA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 LEU A 164
THR A 163
ALA A 162
LEU A 261
LEU A 259
 None
 1.12A 3hm1A-5ddsA:
undetectable		 3hm1A-5ddsA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 6 ILE A 335
VAL A 293
LEU A 297
HIS A 302
 None
 0.90A 3kp6A-5ddsA:
1.3
3kp6B-5ddsA:
0.6		 3kp6A-5ddsA:
14.53
3kp6B-5ddsA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 ILE A  59
THR A 324
GLU A 105
GLU A 316
 None
 1.37A 3ny4A-5ddsA:
undetectable		 3ny4A-5ddsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 VAL A 314
GLY A 337
GLY A 334
SER A 330
ALA A 326
 None
 0.97A 3sufD-5ddsA:
undetectable		 3sufD-5ddsA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 6 ARG A 194
GLN A 136
PHE A 273
PRO A 274
 None
 1.43A 3tgvB-5ddsA:
undetectable		 3tgvB-5ddsA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 6 ARG A 194
GLN A 136
PHE A 273
PRO A 274
 None
 1.39A 3tgvD-5ddsA:
undetectable		 3tgvD-5ddsA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 GLY A 322
ALA A 326
ILE A 321
ILE A  59
VAL A 403
 None
 1.00A 4ax8A-5ddsA:
undetectable		 4ax8A-5ddsA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 VAL A 417
MET A 413
GLU A 415
LEU A 437
 None
 1.20A 4hojA-5ddsA:
undetectable		 4hojA-5ddsA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 GLU A 250
ARG A 303
LEU A 308
ILE A 279
LEU A 203
 None
 1.45A 4k36A-5ddsA:
undetectable		 4k36A-5ddsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 GLU A 250
ARG A 303
LEU A 308
ILE A 279
LEU A 203
 None
 1.42A 4k36B-5ddsA:
undetectable		 4k36B-5ddsA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 11 GLU A 250
ARG A 303
LEU A 308
ILE A 279
LEU A 203
 None
 1.43A 4k37A-5ddsA:
undetectable		 4k37A-5ddsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 11 GLU A 250
ARG A 303
LEU A 308
ILE A 279
LEU A 203
 None
 1.38A 4k37B-5ddsA:
undetectable		 4k37B-5ddsA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 GLN A 318
THR A 319
THR A 294
LEU A 203
 PLP  A 601 (-3.4A)
None
None
None
 1.31A 4lvcC-5ddsA:
undetectable		 4lvcC-5ddsA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 4 VAL A 276
ALA A 234
ILE A 279
THR A 202
 None
 1.20A 5e4dB-5ddsA:
undetectable		 5e4dB-5ddsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 12 LEU A 333
THR A 431
PRO A 283
VAL A 281
LEU A 332
 None
 1.41A 5jo9A-5ddsA:
2.4		 5jo9A-5ddsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 ILE A 346
PHE A 116
SER A  95
ALA A 385
 None
 1.15A 5msdA-5ddsA:
4.0		 5msdA-5ddsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		5 / 9 HIS A  51
VAL A 475
LEU A 505
THR A 501
ALA A 504
 None
 1.45A 5tt3E-5ddsA:
undetectable		 5tt3E-5ddsA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		3 / 3 LEU A 259
VAL A 179
ASP A 180
 None
 0.52A 5x23A-5ddsA:
undetectable		 5x23A-5ddsA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5dds CRMG
(Actinoalloteichu
s
sp.
WH1-2216-6) 		4 / 5 GLN A 318
THR A 319
THR A 294
LEU A 203
 PLP  A 601 (-3.4A)
None
None
None
 1.37A 6gbnA-5ddsA:
undetectable		 6gbnA-5ddsA:
21.70