SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ddz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5ddz RICIN
(Ricinus
communis) 		4 / 4 HIS A  94
ALA A 118
PHE A 117
GLY A 120
 None
 1.30A 1mjoB-5ddzA:
undetectable		 1mjoB-5ddzA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5ddz RICIN
(Ricinus
communis) 		4 / 4 HIS A  94
ALA A 118
PHE A 117
GLY A 120
 None
 1.31A 1mjoA-5ddzA:
undetectable		 1mjoA-5ddzA:
16.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5ddz RICIN
(Ricinus
communis) 		6 / 9 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.47A 1mrgA-5ddzA:
33.9		 1mrgA-5ddzA:
32.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 8 GLY A 121
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.43A 1mrjA-5ddzA:
34.4		 1mrjA-5ddzA:
35.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 8 GLY A 121
TYR A 123
ILE A 172
SER A 176
GLU A 177
 None
 0.25A 1mrjA-5ddzA:
34.4		 1mrjA-5ddzA:
35.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ddz RICIN
(Ricinus
communis) 		5 / 12 ILE A 175
ALA A 178
ALA A 179
ILE A   9
PHE A  24
 None
 0.89A 2aclG-5ddzA:
undetectable		 2aclG-5ddzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_B_ADNB902_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 11 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.48A 2gl0B-5ddzA:
undetectable
2gl0C-5ddzA:
undetectable		 2gl0B-5ddzA:
16.41
2gl0C-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 12 ILE A  25
THR A  17
ALA A  16
VAL A  60
PHE A  24
 None
 1.45A 2gl0A-5ddzA:
undetectable
2gl0C-5ddzA:
undetectable		 2gl0A-5ddzA:
16.41
2gl0C-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 12 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.45A 2gl0D-5ddzA:
undetectable
2gl0E-5ddzA:
undetectable		 2gl0D-5ddzA:
16.41
2gl0E-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_E_ADNE905_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 11 PHE A  24
ILE A  25
THR A  17
ALA A  16
VAL A  60
 None
 1.47A 2gl0E-5ddzA:
undetectable
2gl0F-5ddzA:
undetectable		 2gl0E-5ddzA:
16.41
2gl0F-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 11 ILE A  25
THR A  17
ALA A  16
VAL A  60
PHE A  24
 None
 1.44A 2gl0D-5ddzA:
undetectable
2gl0F-5ddzA:
undetectable		 2gl0D-5ddzA:
16.41
2gl0F-5ddzA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5ddz RICIN
(Ricinus
communis) 		5 / 10 PHE A  24
GLU A  61
LEU A  72
LEU A  74
ILE A 175
 None
 1.25A 3kvrA-5ddzA:
undetectable		 3kvrA-5ddzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5ddz RICIN
(Ricinus
communis) 		4 / 8 ASP A  96
PHE A  93
LEU A  74
ASP A  75
 None
 0.97A 3m0wE-5ddzA:
undetectable
3m0wF-5ddzA:
undetectable
3m0wG-5ddzA:
undetectable
3m0wH-5ddzA:
undetectable		 3m0wE-5ddzA:
15.75
3m0wF-5ddzA:
15.75
3m0wG-5ddzA:
15.75
3m0wH-5ddzA:
15.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 10 ASN A 122
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.87A 3u6tA-5ddzA:
34.2		 3u6tA-5ddzA:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 5ddz RICIN
(Ricinus
communis) 		5 / 11 LEU A  45
SER A 215
LEU A 214
PHE A 181
ALA A  79
 None
 1.28A 4hwkB-5ddzA:
undetectable		 4hwkB-5ddzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 5ddz RICIN
(Ricinus
communis) 		5 / 12 LEU A  45
SER A 215
LEU A 214
PHE A 181
ALA A  79
 None
 1.26A 4hwkC-5ddzA:
undetectable		 4hwkC-5ddzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 5ddz RICIN
(Ricinus
communis) 		5 / 11 LEU A  45
SER A 215
LEU A 214
PHE A 181
ALA A  79
 None
 1.28A 4hwkD-5ddzA:
undetectable		 4hwkD-5ddzA:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 5ddz RICIN
(Ricinus
communis) 		4 / 5 ASN A 122
TYR A 123
ILE A 172
ARG A 180
 None
 0.53A 4o0oA-5ddzA:
34.3		 4o0oA-5ddzA:
32.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5ddz RICIN
(Ricinus
communis) 		3 / 3 GLU A 177
ALA A 178
PHE A 181
 None
 0.53A 4v1fA-5ddzA:
undetectable		 4v1fA-5ddzA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5ddz RICIN
(Ricinus
communis) 		3 / 3 GLU A 177
ALA A 178
PHE A 181
 None
 0.49A 4v1fC-5ddzA:
undetectable		 4v1fC-5ddzA:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5ddz RICIN
(Ricinus
communis) 		6 / 9 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.40A 4yp2B-5ddzA:
34.4		 4yp2B-5ddzA:
34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5ddz RICIN
(Ricinus
communis) 		6 / 9 PHE A  93
GLY A 121
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.40A 5cf9B-5ddzA:
34.4		 5cf9B-5ddzA:
34.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ddz RICIN
(Ricinus
communis) 		4 / 5 TYR A  84
SER A 149
ALA A 150
THR A 163
 None
 1.34A 5n4iA-5ddzA:
undetectable		 5n4iA-5ddzA:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 5ddz RICIN
(Ricinus
communis) 		5 / 6 VAL A  81
TYR A 123
ILE A 172
GLU A 177
ARG A 180
 None
 0.38A 5z3jA-5ddzA:
35.6		 5z3jA-5ddzA:
41.37