SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5de0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 118
ILE A  97
LEU A  37
PRO A  38
ILE A 115
 None
 0.87A 1dhjB-5de0A:
undetectable		 1dhjB-5de0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 7 MET A 259
SER A 232
ALA A 248
ILE A 228
 HEM  A 401 (-3.8A)
None
None
HEM  A 401 ( 4.7A)
 1.06A 1fxhA-5de0A:
undetectable
1fxhB-5de0A:
undetectable		 1fxhA-5de0A:
21.36
1fxhB-5de0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 4 HIS A 100
ALA A 101
PHE A  15
GLY A  13
 None
 0.78A 1mj2B-5de0A:
undetectable		 1mj2B-5de0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 4 HIS A 100
ALA A 101
PHE A  15
GLY A  13
 None
 0.83A 1mj2D-5de0A:
undetectable		 1mj2D-5de0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 4 HIS A 100
ALA A 101
PHE A  15
GLY A  13
 None
 0.82A 1mjoB-5de0A:
undetectable		 1mjoB-5de0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 4 HIS A 100
ALA A 101
PHE A  15
GLY A  13
 None
 0.90A 1mjoA-5de0A:
undetectable		 1mjoA-5de0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 4 HIS A 100
ALA A 101
PHE A  15
GLY A  13
 None
 0.79A 1mjoD-5de0A:
undetectable		 1mjoD-5de0A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 9 LEU A  21
LEU A  34
VAL A  55
ALA A   7
GLN A   5
 None
 1.18A 1tbfA-5de0A:
undetectable		 1tbfA-5de0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 10 ALA A  33
ILE A 115
ASP A  94
LEU A  21
ILE A 122
 None
 0.94A 1yi4A-5de0A:
undetectable		 1yi4A-5de0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CPP_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 7 THR A  91
LEU A  21
VAL A 125
VAL A 173
 None
 0.71A 2cppA-5de0A:
undetectable		 2cppA-5de0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		3 / 3 LYS A 150
ARG A 230
LYS A 220
 None
HEM  A 401 (-2.6A)
None
 1.28A 3okxA-5de0A:
undetectable		 3okxA-5de0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		3 / 3 TYR A 133
ASP A 135
ASP A 201
 None
 0.81A 3ou6B-5de0A:
undetectable		 3ou6B-5de0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 228
VAL A 217
LEU A 260
GLY A 145
ASP A 144
 HEM  A 401 ( 4.7A)
HEM  A 401 (-4.3A)
HEM  A 401 ( 4.5A)
HEM  A 401 (-3.2A)
HEM  A 401 ( 4.7A)
 0.97A 3uq6A-5de0A:
undetectable		 3uq6A-5de0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 228
VAL A 217
LEU A 260
GLY A 145
ASP A 144
 HEM  A 401 ( 4.7A)
HEM  A 401 (-4.3A)
HEM  A 401 ( 4.5A)
HEM  A 401 (-3.2A)
HEM  A 401 ( 4.7A)
 0.95A 3uq6B-5de0A:
undetectable		 3uq6B-5de0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 228
VAL A 217
LEU A 260
GLY A 145
ASP A 144
 HEM  A 401 ( 4.7A)
HEM  A 401 (-4.3A)
HEM  A 401 ( 4.5A)
HEM  A 401 (-3.2A)
HEM  A 401 ( 4.7A)
 0.98A 3vaqA-5de0A:
undetectable		 3vaqA-5de0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 228
VAL A 217
LEU A 260
GLY A 145
ASP A 144
 HEM  A 401 ( 4.7A)
HEM  A 401 (-4.3A)
HEM  A 401 ( 4.5A)
HEM  A 401 (-3.2A)
HEM  A 401 ( 4.7A)
 1.04A 3vaqB-5de0A:
undetectable		 3vaqB-5de0A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 228
VAL A 217
LEU A 260
GLY A 145
ASP A 144
 HEM  A 401 ( 4.7A)
HEM  A 401 (-4.3A)
HEM  A 401 ( 4.5A)
HEM  A 401 (-3.2A)
HEM  A 401 ( 4.7A)
 0.96A 3vasA-5de0A:
undetectable		 3vasA-5de0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 228
VAL A 217
LEU A 260
GLY A 145
ASP A 144
 HEM  A 401 ( 4.7A)
HEM  A 401 (-4.3A)
HEM  A 401 ( 4.5A)
HEM  A 401 (-3.2A)
HEM  A 401 ( 4.7A)
 1.03A 3vasB-5de0A:
undetectable		 3vasB-5de0A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 8 THR A  91
LEU A  21
VAL A 125
VAL A 173
 None
 0.70A 4l4aA-5de0A:
undetectable		 4l4aA-5de0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 118
THR A  19
LEU A  37
PRO A  38
ILE A 115
 None
 1.05A 4p3qA-5de0A:
undetectable		 4p3qA-5de0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 ILE A 118
THR A  19
ILE A  97
LEU A  37
PRO A  38
 None
 1.10A 5eajB-5de0A:
undetectable		 5eajB-5de0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 7 ALA A   7
THR A   6
VAL A  41
HIS A 100
 None
 1.16A 5ecnA-5de0A:
undetectable		 5ecnA-5de0A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 GLY A 114
LEU A  40
ILE A 247
TYR A 129
TYR A  18
 None
 1.46A 5fepA-5de0A:
undetectable		 5fepA-5de0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 12 GLY A 114
LEU A  40
ILE A 247
TYR A 129
TYR A  18
 None
 1.45A 5fesA-5de0A:
undetectable		 5fesA-5de0A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 11 LEU A 253
TYR A 285
GLY A  62
ILE A  76
PRO A  72
 None
 1.31A 5hjiA-5de0A:
undetectable		 5hjiA-5de0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		3 / 3 TYR A 264
TYR A 285
GLN A 174
 None
None
HEM  A 401 (-4.3A)
 1.11A 5jsdA-5de0A:
undetectable
5jsdB-5de0A:
undetectable		 5jsdA-5de0A:
18.25
5jsdB-5de0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		3 / 3 TYR A 264
TYR A 285
GLN A 174
 None
None
HEM  A 401 (-4.3A)
 1.11A 5jsdB-5de0A:
undetectable
5jsdC-5de0A:
undetectable		 5jsdB-5de0A:
18.25
5jsdC-5de0A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		3 / 3 GLU A 206
LEU A 205
ARG A 197
 None
None
HEM  A 401 (-4.8A)
 0.71A 6d8fA-5de0A:
undetectable		 6d8fA-5de0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_B_DZPB502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		5 / 11 LEU A  37
PRO A  38
THR A   6
MET A 293
LEU A 297
 None
 1.49A 6hupA-5de0A:
undetectable
6hupB-5de0A:
undetectable		 6hupA-5de0A:
16.42
6hupB-5de0A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 5de0 DEFERROCHELATASE
(Vibrio
cholerae) 		4 / 6 MET A 139
THR A 140
THR A 278
LEU A 186
 None
HEM  A 401 ( 4.6A)
HEM  A 401 (-3.5A)
None
 1.15A 6mvxA-5de0A:
undetectable
6mvxB-5de0A:
undetectable
6mvxC-5de0A:
undetectable		 6mvxA-5de0A:
20.19
6mvxB-5de0A:
20.19
6mvxC-5de0A:
20.19