SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 162
PRO A 178
SER A 165
ALA A 190
 None
 0.87A 1gxsA-5demA:
undetectable
1gxsB-5demA:
undetectable		 1gxsA-5demA:
20.27
1gxsB-5demA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A  16
GLY A  37
GLY A  35
ILE A  40
PRO A  24
 None
 1.08A 1p91A-5demA:
undetectable		 1p91A-5demA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 137
ILE A  82
GLY A  83
GLY A 108
ILE A 119
 None
 0.97A 1sdtA-5demA:
undetectable		 1sdtA-5demA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A 137
ILE A  82
GLY A  83
GLY A 108
ILE A 119
 None
 0.95A 1sdvA-5demA:
undetectable		 1sdvA-5demA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		3 / 3 SER A  63
SER A  62
HIS A 118
 None
 0.74A 3mzeA-5demA:
undetectable		 3mzeA-5demA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 125
ILE A 173
LEU A 149
VAL A 143
THR A 105
 None
 0.84A 3n0hA-5demA:
undetectable		 3n0hA-5demA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 125
ILE A 173
LEU A 149
VAL A 143
THR A 105
 None
 0.83A 3s3vA-5demA:
undetectable		 3s3vA-5demA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  28
SER A  26
ILE A  52
ILE A  58
PHE A  61
 None
 1.18A 3w67D-5demA:
undetectable		 3w67D-5demA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 125
ILE A 173
LEU A 149
VAL A 143
THR A 105
 None
 1.04A 4kfjB-5demA:
undetectable		 4kfjB-5demA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A  92
ILE A  88
ARG A  89
ILE A  94
GLY A  83
 None
 1.05A 4kukA-5demA:
undetectable		 4kukA-5demA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A   8
VAL A  28
ILE A  40
LEU A  46
ILE A  10
 None
 1.07A 6dh6B-5demA:
undetectable		 6dh6B-5demA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5dem ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE
(Pseudomonas
aeruginosa) 		5 / 9 LEU A 149
SER A 150
THR A 153
ILE A 173
VAL A 177
 None
 1.07A 6ef6A-5demA:
undetectable		 6ef6A-5demA:
22.16