SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5deu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 5 THR A1393
ASP A1384
HIS A1382
HIS A1881
 CL  A2007 (-4.5A)
FE  A2003 ( 2.4A)
FE  A2003 (-3.3A)
FE  A2003 ( 3.2A)
 0.98A 1ei6A-5deuA:
undetectable		 1ei6A-5deuA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 6 ILE A1444
LYS A1197
ALA A1196
VAL A1423
 None
 0.97A 1hk1A-5deuA:
undetectable		 1hk1A-5deuA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_B_TOYB501_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 9 ASP A1384
SER A1286
SER A1284
ALA A1283
THR A1259
 FE  A2003 ( 2.4A)
None
None
None
None
 1.41A 1m4dB-5deuA:
undetectable		 1m4dB-5deuA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 12 HIS A1382
ASP A1384
HIS A1881
SER A1898
VAL A1900
 FE  A2003 (-3.3A)
FE  A2003 ( 2.4A)
FE  A2003 ( 3.2A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
 0.61A 1uobA-5deuA:
7.6		 1uobA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 12 SER A1286
HIS A1881
LEU A1872
SER A1898
VAL A1900
 None
FE  A2003 ( 3.2A)
None
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
 1.50A 1uobA-5deuA:
7.6		 1uobA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 11 HIS A1382
ASP A1384
ARG A1896
SER A1898
VAL A1900
 FE  A2003 (-3.3A)
FE  A2003 ( 2.4A)
OGA  A2001 (-2.9A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
 1.00A 1uofA-5deuA:
7.1		 1uofA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 11 HIS A1382
ASP A1384
HIS A1881
SER A1898
VAL A1900
 FE  A2003 (-3.3A)
FE  A2003 ( 2.4A)
FE  A2003 ( 3.2A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
 0.79A 1uofA-5deuA:
7.1		 1uofA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 11 HIS A1382
THR A1393
HIS A1881
SER A1898
VAL A1900
 FE  A2003 (-3.3A)
CL  A2007 (-4.5A)
FE  A2003 ( 3.2A)
OGA  A2001 (-2.7A)
OGA  A2001 ( 4.9A)
 0.74A 1uofA-5deuA:
7.1		 1uofA-5deuA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		3 / 3 CYH A1273
CYH A1193
HIS A1380
 ZN  A2005 (-2.3A)
ZN  A2005 (-2.4A)
ZN  A2005 (-3.2A)
 0.85A 2iwkA-5deuA:
undetectable		 2iwkA-5deuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		3 / 3 CYH A1273
CYH A1193
HIS A1380
 ZN  A2005 (-2.3A)
ZN  A2005 (-2.4A)
ZN  A2005 (-3.2A)
 0.83A 2iwkB-5deuA:
undetectable		 2iwkB-5deuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 8 MET A1333
LEU A1329
PRO A1367
GLY A1370
 None
 0.98A 2qd5A-5deuA:
undetectable		 2qd5A-5deuA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 12 GLY A1282
GLY A1256
ASN A1890
THR A1249
THR A1251
 None
 1.15A 3eeyC-5deuA:
undetectable		 3eeyC-5deuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 12 GLY A1282
GLY A1256
ASN A1890
THR A1249
THR A1251
 None
 1.15A 3eeyE-5deuA:
undetectable		 3eeyE-5deuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 12 GLY A1282
GLY A1256
ASN A1890
THR A1249
THR A1251
 None
 1.15A 3eeyF-5deuA:
undetectable		 3eeyF-5deuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 7 MET A1333
LEU A1329
PRO A1367
GLY A1370
 None
 1.07A 3hcnA-5deuA:
undetectable		 3hcnA-5deuA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 8 ASP A1376
TYR A1245
SER A1898
ILE A1897
 None
None
OGA  A2001 (-2.7A)
None
 0.89A 3ihzB-5deuA:
undetectable		 3ihzB-5deuA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 5 ILE A1859
SER A1189
LYS A1188
GLY A1187
 None
 1.08A 3tkdB-5deuA:
undetectable		 3tkdB-5deuA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 5 ILE A1859
SER A1189
LYS A1188
GLY A1187
 None
 1.06A 3tkdA-5deuA:
undetectable		 3tkdA-5deuA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		3 / 3 GLN A1348
PHE A1368
TYR A1337
 None
 0.94A 3ucjB-5deuA:
undetectable		 3ucjB-5deuA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		3 / 3 GLN A1348
PHE A1368
TYR A1337
 None
 0.99A 3ucjA-5deuA:
undetectable		 3ucjA-5deuA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F92_B_SANB2201_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 9 TYR A1345
ASN A1347
GLN A1348
GLY A1391
SER A1392
 None
 1.25A 4f92B-5deuA:
0.0		 4f92B-5deuA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 7 GLY A1365
GLU A1364
GLN A1903
MET A1388
 None
 1.07A 4g0vA-5deuA:
undetectable		 4g0vA-5deuA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 6 GLY A1365
GLU A1364
GLN A1903
MET A1388
 None
 0.92A 4g0vB-5deuA:
undetectable		 4g0vB-5deuA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 8 THR A1183
GLY A1860
GLY A1861
VAL A1862
 None
 0.76A 4qvvK-5deuA:
undetectable
4qvvL-5deuA:
undetectable		 4qvvK-5deuA:
18.42
4qvvL-5deuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 8 THR A1183
GLY A1860
GLY A1861
VAL A1862
 None
 0.76A 4qvvY-5deuA:
undetectable
4qvvZ-5deuA:
undetectable		 4qvvY-5deuA:
18.42
4qvvZ-5deuA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 10 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
 OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
 1.36A 4yhaB-5deuA:
undetectable		 4yhaB-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 12 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
 OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
 1.49A 4yhaG-5deuA:
undetectable		 4yhaG-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 9 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
 OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
 1.42A 5tt3E-5deuA:
undetectable		 5tt3E-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		5 / 9 HIS A1416
HIS A1881
VAL A1395
VAL A1900
ALA A1379
 OGA  A2001 (-3.9A)
FE  A2003 ( 3.2A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.9A)
OGA  A2001 ( 4.4A)
 1.46A 5tt3G-5deuA:
undetectable		 5tt3G-5deuA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		3 / 3 LYS A1208
SER A1203
SER A1204
 None
 0.97A 6gbfA-5deuA:
undetectable		 6gbfA-5deuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens) 		4 / 8 VAL A1227
ASN A1156
GLU A1222
CYH A1221
 None
None
None
ZN  A2004 (-2.3A)
 1.17A 6gneB-5deuA:
undetectable		 6gneB-5deuA:
20.91