SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 375
HIS A 374
ALA A 337
THR A 325
 None
 0.89A 1gtfN-5dfaA:
1.4
1gtfO-5dfaA:
undetectable		 1gtfN-5dfaA:
6.85
1gtfO-5dfaA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 PHE A 389
ASN A  23
GLY A 375
TYR A 287
ALA A 323
 None
None
None
GOL  A 703 (-4.8A)
GOL  A 703 ( 4.7A)
 1.17A 1hvyA-5dfaA:
undetectable		 1hvyA-5dfaA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A  87
VAL A  51
GLY A  52
ASP A  72
 None
 0.41A 1p2yA-5dfaA:
undetectable		 1p2yA-5dfaA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A  87
VAL A  51
GLY A  52
ASP A  72
 None
 0.49A 1t88A-5dfaA:
undetectable		 1t88A-5dfaA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 LEU A  87
VAL A  51
GLY A  52
ASP A  72
 None
 0.68A 2a1oA-5dfaA:
undetectable		 2a1oA-5dfaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A  37
ASP A  77
ASN A  23
 None
 0.78A 2bm9D-5dfaA:
undetectable		 2bm9D-5dfaA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 GLU A 482
GLN A 520
ARG A 523
 None
 0.71A 2w3bB-5dfaA:
undetectable		 2w3bB-5dfaA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 663
GLU A 684
ILE A 405
ALA A 412
 None
 0.62A 2xkwA-5dfaA:
undetectable		 2xkwA-5dfaA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 MET A 402
PHE A 344
ALA A 352
VAL A 629
ILE A 644
 None
 1.21A 3dl9A-5dfaA:
undetectable		 3dl9A-5dfaA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 629
HIS A 625
ASP A 454
VAL A 642
VAL A 683
 None
GOL  A 702 (-3.5A)
GOL  A 702 ( 4.8A)
None
None
 1.30A 3fi0D-5dfaA:
undetectable		 3fi0D-5dfaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 629
HIS A 625
ASP A 454
VAL A 642
VAL A 683
 None
GOL  A 702 (-3.5A)
GOL  A 702 ( 4.8A)
None
None
 1.20A 3fi0F-5dfaA:
undetectable		 3fi0F-5dfaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 629
HIS A 625
ASP A 454
VAL A 642
VAL A 683
 None
GOL  A 702 (-3.5A)
GOL  A 702 ( 4.8A)
None
None
 1.22A 3fi0H-5dfaA:
undetectable		 3fi0H-5dfaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 629
HIS A 625
ASP A 454
VAL A 642
VAL A 683
 None
GOL  A 702 (-3.5A)
GOL  A 702 ( 4.8A)
None
None
 1.29A 3fi0J-5dfaA:
undetectable		 3fi0J-5dfaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 VAL A 629
HIS A 625
ASP A 454
VAL A 642
VAL A 683
 None
GOL  A 702 (-3.5A)
GOL  A 702 ( 4.8A)
None
None
 1.26A 3fi0K-5dfaA:
undetectable		 3fi0K-5dfaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLN A 591
THR A 497
THR A 501
HIS A 446
 None
 1.46A 3g1uA-5dfaA:
2.4		 3g1uA-5dfaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLN A 591
THR A 497
THR A 501
HIS A 446
 None
 1.45A 3g1uC-5dfaA:
undetectable		 3g1uC-5dfaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLN A 591
THR A 497
THR A 501
HIS A 446
 None
 1.49A 3glqB-5dfaA:
undetectable		 3glqB-5dfaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 ARG A 107
ARG A 120
GLY A 119
GLU A 371
 None
GOL  A 703 (-3.0A)
None
GOL  A 703 (-3.1A)
 1.11A 3k9fA-5dfaA:
undetectable
3k9fB-5dfaA:
undetectable
3k9fD-5dfaA:
undetectable		 3k9fA-5dfaA:
22.02
3k9fB-5dfaA:
22.02
3k9fD-5dfaA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
 None
 1.11A 3lxiA-5dfaA:
undetectable		 3lxiA-5dfaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 11 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
 None
 1.13A 3lxiB-5dfaA:
undetectable		 3lxiB-5dfaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 TYR A 641
VAL A 660
ILE A 644
ARG A 618
 None
 0.94A 3mssB-5dfaA:
undetectable		 3mssB-5dfaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 GLN A 591
THR A 497
THR A 501
HIS A 446
 None
 1.47A 3n58A-5dfaA:
5.2		 3n58A-5dfaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
 None
 1.18A 4c9kA-5dfaA:
undetectable		 4c9kA-5dfaA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
 None
 1.19A 4c9nB-5dfaA:
undetectable		 4c9nB-5dfaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_A_CAMA423_0
(CYTOCHROME P450)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 9 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
 None
 1.16A 4c9pA-5dfaA:
undetectable		 4c9pA-5dfaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 10 THR A  48
THR A  10
LEU A 359
LEU A 320
VAL A 406
 None
 1.16A 4c9pB-5dfaA:
undetectable		 4c9pB-5dfaA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ARG A 227
TRP A 192
GLY A 220
 None
 0.67A 4e7cA-5dfaA:
undetectable		 4e7cA-5dfaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 604
GLY A 597
ILE A 595
 None
 0.55A 4k50A-5dfaA:
undetectable		 4k50A-5dfaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 HIS A 604
GLY A 597
ILE A 595
 None
 0.55A 4k50I-5dfaA:
undetectable		 4k50I-5dfaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 346
MET A 350
ASP A 299
 None
 0.95A 4mm4B-5dfaA:
undetectable		 4mm4B-5dfaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 LEU A 359
SER A 283
LEU A  17
ASN A 158
 None
None
None
GOL  A 703 ( 4.0A)
 1.16A 4n09B-5dfaA:
3.8		 4n09B-5dfaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A  17
ASN A  47
MET A  41
VAL A 377
 None
 1.18A 4okbA-5dfaA:
undetectable		 4okbA-5dfaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A 597
TYR A 556
TYR A 576
ALA A 581
ASN A 542
 None
 1.41A 4ymgA-5dfaA:
undetectable		 4ymgA-5dfaA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 TRP A 176
ARG A 227
LEU A 188
 None
 1.00A 5dbyA-5dfaA:
undetectable		 5dbyA-5dfaA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 ILE A  16
ILE A 351
ARG A 634
LEU A  17
 None
 0.84A 5dzkh-5dfaA:
undetectable
5dzkn-5dfaA:
undetectable
5dzkv-5dfaA:
undetectable		 5dzkh-5dfaA:
15.48
5dzkn-5dfaA:
15.48
5dzkv-5dfaA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 375
HIS A 374
ALA A 337
THR A 325
 None
 0.89A 5eezL-5dfaA:
undetectable
5eezV-5dfaA:
undetectable		 5eezL-5dfaA:
6.85
5eezV-5dfaA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 375
HIS A 374
ALA A 337
THR A 325
 None
 0.89A 5ef1L-5dfaA:
0.9
5ef1V-5dfaA:
undetectable		 5ef1L-5dfaA:
6.85
5ef1V-5dfaA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 8 GLY A 375
HIS A 374
ALA A 337
THR A 325
 None
 0.89A 5ef2L-5dfaA:
0.8
5ef2V-5dfaA:
undetectable		 5ef2L-5dfaA:
6.85
5ef2V-5dfaA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		5 / 12 TYR A 160
PHE A  75
GLY A 146
THR A 248
LEU A 244
 None
 1.19A 5esgA-5dfaA:
undetectable		 5esgA-5dfaA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 HIS A 291
LEU A 300
PRO A 288
SER A 346
 None
 1.10A 5syjA-5dfaA:
undetectable		 5syjA-5dfaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 HIS A 291
LEU A 300
PRO A 288
SER A 346
 None
 1.11A 5syjB-5dfaA:
undetectable		 5syjB-5dfaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 7 LEU A 141
ALA A  88
ILE A 253
LEU A 244
 None
 1.00A 5te8A-5dfaA:
undetectable		 5te8A-5dfaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 SER A 347
HIS A 343
TYR A 360
 None
 0.92A 5y2tA-5dfaA:
undetectable		 5y2tA-5dfaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 606
ARG A 549
ASP A 601
 None
 0.85A 5zvgA-5dfaA:
undetectable		 5zvgA-5dfaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 606
ARG A 549
ASP A 601
 None
 0.83A 5zvgB-5dfaA:
undetectable		 5zvgB-5dfaA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 6 LYS A 470
ARG A 468
GLU A 413
ALA A 412
 None
 0.98A 6an0A-5dfaA:
undetectable		 6an0A-5dfaA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_2
(-)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLN A 591
THR A 497
THR A 501
HIS A 446
 None
 1.50A 6f3nA-5dfaA:
undetectable		 6f3nA-5dfaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_2
(-)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLN A 591
THR A 497
THR A 501
HIS A 446
 None
 1.49A 6f3nC-5dfaA:
undetectable		 6f3nC-5dfaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_2
(-)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 4 GLN A 591
THR A 497
THR A 501
HIS A 446
 None
 1.49A 6f3nD-5dfaA:
undetectable		 6f3nD-5dfaA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		4 / 5 TYR A 145
GLY A 146
HIS A 148
ASP A  76
 None
 1.03A 6gh9A-5dfaA:
undetectable		 6gh9A-5dfaA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 5dfa BETA-GALACTOSIDASE
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 578
SER A 550
SER A 543
 None
 0.75A 6mxtA-5dfaA:
undetectable		 6mxtA-5dfaA:
23.01