SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dfm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		3 / 3 GLU A 111
TRP A 230
LYS A 273
 MAL  A 601 (-3.0A)
MAL  A 601 ( 4.9A)
None
 1.28A 1qu2A-5dfmA:
undetectable		 1qu2A-5dfmA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 6 GLU A 310
TYR A 307
ASP A 314
ARG A 316
 None
 1.41A 2a3bB-5dfmA:
undetectable		 2a3bB-5dfmA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 ALA A 231
ASP A 296
TYR A 210
ASN A 234
GLY A 228
 None
 1.29A 2dcfA-5dfmA:
undetectable		 2dcfA-5dfmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 6 ASP A 197
THR A 193
LYS A 200
ASP A 358
 None
 1.28A 2j2pE-5dfmA:
undetectable
2j2pF-5dfmA:
undetectable		 2j2pE-5dfmA:
17.89
2j2pF-5dfmA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		3 / 3 TYR A 493
GLY A 411
PHE A 413
 None
 0.71A 2m2pB-5dfmA:
undetectable		 2m2pB-5dfmA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.09A 2ve3A-5dfmA:
undetectable		 2ve3A-5dfmA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 11 ALA A 231
ASP A 296
TYR A 210
ASN A 234
GLY A 228
 None
 1.27A 2zmaA-5dfmA:
undetectable		 2zmaA-5dfmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 7 ILE A 499
LEU A 509
PHE A 474
THR A 385
 None
None
None
SO4  A 604 (-4.0A)
 0.97A 2zxwN-5dfmA:
undetectable
2zxwW-5dfmA:
undetectable		 2zxwN-5dfmA:
21.09
2zxwW-5dfmA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		3 / 3 MET A 330
GLU A 111
ASP A  14
 MAL  A 601 ( 4.3A)
MAL  A 601 (-3.0A)
SO4  A 602 ( 4.7A)
 0.97A 3a25A-5dfmA:
undetectable		 3a25A-5dfmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 ILE A 108
LEU A 262
ILE A  59
VAL A  23
LEU A  20
 None
 1.06A 3a51C-5dfmA:
undetectable		 3a51C-5dfmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 7 ILE A 499
LEU A 509
PHE A 474
THR A 385
 None
None
None
SO4  A 604 (-4.0A)
 1.01A 3ag2N-5dfmA:
undetectable
3ag2W-5dfmA:
undetectable		 3ag2N-5dfmA:
21.09
3ag2W-5dfmA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 7 ILE A 499
LEU A 509
PHE A 474
THR A 385
 None
None
None
SO4  A 604 (-4.0A)
 0.97A 3ag4N-5dfmA:
undetectable
3ag4W-5dfmA:
undetectable		 3ag4N-5dfmA:
21.09
3ag4W-5dfmA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_A_MXDA551_1
(PROSTACYCLIN
SYNTHASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 6 ALA A 188
LEU A 192
ALA A 346
THR A 345
 None
 0.92A 3b6hA-5dfmA:
undetectable		 3b6hA-5dfmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.92A 3bgdA-5dfmA:
undetectable		 3bgdA-5dfmA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.79A 3bjwC-5dfmA:
undetectable		 3bjwC-5dfmA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 7 LEU A 290
LEU A  43
LEU A  20
LEU A  76
 None
 0.86A 3g8iA-5dfmA:
undetectable		 3g8iA-5dfmA:
20.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 SO4  A 602 (-3.5A)
MAL  A 601 (-4.3A)
MAL  A 601 ( 3.7A)
MAL  A 601 (-4.0A)
MAL  A 601 ( 4.3A)
MAL  A 601 (-3.6A)
 0.51A 3jyrA-5dfmA:
60.6		 3jyrA-5dfmA:
69.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 11 GLN A 365
ALA A 364
ALA A 162
GLY A 166
ALA A 188
 None
 1.09A 3mg0V-5dfmA:
undetectable
3mg0W-5dfmA:
undetectable		 3mg0V-5dfmA:
17.47
3mg0W-5dfmA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.01A 3n8yB-5dfmA:
undetectable		 3n8yB-5dfmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 601 (-3.0A)
None
 0.83A 3tbgB-5dfmA:
undetectable		 3tbgB-5dfmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 None
None
None
MAL  A 601 (-3.0A)
None
 0.82A 3tbgD-5dfmA:
undetectable		 3tbgD-5dfmA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 10 ALA A 231
ASP A 296
TYR A 210
ASN A 234
GLY A 228
 None
 1.28A 3vwpA-5dfmA:
undetectable		 3vwpA-5dfmA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
SO4  A 606 (-4.5A)
None
None
None
 1.39A 3vwqA-5dfmA:
undetectable		 3vwqA-5dfmA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 11 ALA A 231
ASP A 296
TYR A 210
ASN A 234
GLY A 228
 None
 1.29A 3vwrA-5dfmA:
undetectable		 3vwrA-5dfmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.32A 3vywD-5dfmA:
undetectable		 3vywD-5dfmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 SER A 337
GLY A  68
ALA A  71
TYR A 381
GLU A  45
 None
 1.15A 4bupB-5dfmA:
undetectable		 4bupB-5dfmA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 8 ASP A 386
VAL A 407
PHE A 474
LEU A 507
 None
None
None
GOL  A 607 (-4.1A)
 0.98A 4f8hA-5dfmA:
undetectable
4f8hB-5dfmA:
undetectable		 4f8hA-5dfmA:
18.22
4f8hB-5dfmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 8 ASP A 386
VAL A 407
PHE A 474
LEU A 507
 None
None
None
GOL  A 607 (-4.1A)
 1.03A 4f8hB-5dfmA:
undetectable
4f8hC-5dfmA:
undetectable		 4f8hB-5dfmA:
18.22
4f8hC-5dfmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 8 ASP A 386
VAL A 407
PHE A 474
LEU A 507
 None
None
None
GOL  A 607 (-4.1A)
 0.98A 4f8hC-5dfmA:
undetectable
4f8hD-5dfmA:
undetectable		 4f8hC-5dfmA:
18.22
4f8hD-5dfmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 8 ASP A 386
VAL A 407
PHE A 474
LEU A 507
 None
None
None
GOL  A 607 (-4.1A)
 0.99A 4f8hD-5dfmA:
undetectable
4f8hE-5dfmA:
undetectable		 4f8hD-5dfmA:
18.22
4f8hE-5dfmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 8 VAL A 407
PHE A 474
LEU A 507
ASP A 386
 None
None
GOL  A 607 (-4.1A)
None
 1.01A 4f8hA-5dfmA:
undetectable
4f8hE-5dfmA:
undetectable		 4f8hA-5dfmA:
18.22
4f8hE-5dfmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 7 PRO A 331
ALA A 168
LYS A 256
TYR A 155
 None
None
None
MAL  A 601 (-4.0A)
 1.06A 4lb2A-5dfmA:
undetectable		 4lb2A-5dfmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 ILE A 409
VAL A 407
LEU A 383
LEU A 507
LEU A 509
 None
None
None
GOL  A 607 (-4.1A)
None
 1.04A 4m11B-5dfmA:
undetectable		 4m11B-5dfmA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.17A 4or0B-5dfmA:
undetectable		 4or0B-5dfmA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 11 ILE A 132
LEU A 139
LEU A 122
ALA A 223
LEU A 115
 None
 1.06A 4p65E-5dfmA:
undetectable
4p65F-5dfmA:
undetectable
4p65J-5dfmA:
undetectable
4p65L-5dfmA:
undetectable		 4p65E-5dfmA:
2.62
4p65F-5dfmA:
5.57
4p65J-5dfmA:
5.57
4p65L-5dfmA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		4 / 6 ILE A 499
LEU A 509
PHE A 474
THR A 385
 None
None
None
SO4  A 604 (-4.0A)
 0.98A 5b1aN-5dfmA:
2.0
5b1aW-5dfmA:
undetectable		 5b1aN-5dfmA:
21.09
5b1aW-5dfmA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.45A 5w4zA-5dfmA:
undetectable		 5w4zA-5dfmA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
 1.50A 5w4zB-5dfmA:
undetectable		 5w4zB-5dfmA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 SER A 337
GLY A  68
ALA A  71
TYR A 381
GLU A  45
 None
 1.11A 5wbvA-5dfmA:
undetectable		 5wbvA-5dfmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 SER A 337
GLY A  68
ALA A  71
TYR A 381
GLU A  45
 None
 1.11A 5wbvB-5dfmA:
undetectable		 5wbvB-5dfmA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		3 / 3 TYR A 155
ASN A 227
LEU A 113
 MAL  A 601 (-4.0A)
None
None
 0.81A 6b58A-5dfmA:
undetectable		 6b58A-5dfmA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.39A 6bm5A-5dfmA:
undetectable		 6bm5A-5dfmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 12 GLN A 365
ALA A 364
ALA A 162
GLY A 166
ALA A 188
 None
 1.00A 6hwdH-5dfmA:
undetectable
6hwdI-5dfmA:
undetectable		 6hwdH-5dfmA:
10.69
6hwdI-5dfmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19
(Escherichia
coli;
Tetrahymena
thermophila) 		5 / 11 GLN A 365
ALA A 364
ALA A 162
GLY A 166
ALA A 188
 None
 1.00A 6hwdV-5dfmA:
undetectable		 6hwdV-5dfmA:
10.69