SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		4 / 5 GLN H 716
THR H 715
ARG H 551
ALA H 552
 None
 1.41A 2qhfA-5dfwH:
undetectable		 2qhfA-5dfwH:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		5 / 9 THR H 306
LEU H 104
ARG H 103
ILE H 252
GLY H 255
 None
 1.26A 3cv9A-5dfwH:
undetectable		 3cv9A-5dfwH:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		3 / 3 LYS H 501
GLU H 556
TRP H 754
 None
 1.40A 3v4tH-5dfwH:
undetectable		 3v4tH-5dfwH:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		3 / 3 LEU H 104
LYS H 102
THR H 124
 None
 0.59A 4lj0A-5dfwH:
undetectable		 4lj0A-5dfwH:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		3 / 3 THR H 518
ASN H 722
SER H 723
 None
 0.51A 4tvtA-5dfwH:
undetectable		 4tvtA-5dfwH:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		5 / 12 TYR H 602
GLN H 604
ILE H 308
THR H 124
PHE H 753
 None
 1.29A 5fsaB-5dfwH:
undetectable		 5fsaB-5dfwH:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		4 / 7 GLY H 214
TYR H 602
TRP H 798
TYR H 328
 None
 1.17A 5vlmG-5dfwH:
undetectable		 5vlmG-5dfwH:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		5 / 12 TYR H 602
LEU H 612
PHE H 152
HIS H 199
LEU H 598
 None
 0.98A 6djzA-5dfwH:
undetectable		 6djzA-5dfwH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		5 / 12 TYR H 602
LEU H 612
PHE H 152
HIS H 199
LEU H 598
 None
 1.10A 6djzB-5dfwH:
undetectable		 6djzB-5dfwH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5dfw SINGLE CHAIN FV
FRAGMENT
(Mus
musculus) 		4 / 5 GLY H 289
ASN H 290
ASP H 253
ARG H 251
 None
 1.38A 6dwdB-5dfwH:
undetectable
6dwdD-5dfwH:
undetectable		 6dwdB-5dfwH:
17.77
6dwdD-5dfwH:
17.77