SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4F_A_ADNA601_2 (S-ADENOSYLHOMOCYSTEI NE HYDROLASE)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 5	THR A 281 GLU A 299 THR A 300 HIS A 261	None	1.07A	1d4fA-5dggA: undetectable	1d4fA-5dggA: 17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GTI_C_CCSC47_0 (GLUTATHIONE S-TRANSFERASE)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 6	THR A 240 GLY A 186 LYS A 263 TYR A 259	None	1.18A	1gtiC-5dggA: undetectable	1gtiC-5dggA: 25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S1X_A_NVPA999_1 (REVERSE TRANSCRIPTASE)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 8	LEU A 224 VAL A 187 LEU A 148 TYR A 220	None	0.84A	1s1xA-5dggA: undetectable	1s1xA-5dggA: 16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V81_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 8	LEU A 224 VAL A 187 LEU A 148 TYR A 220	None	0.74A	3v81C-5dggA: undetectable	3v81C-5dggA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4B3Q_A_NVPA999_1 (REVERSE TRANSCRIPTASE/RIBONU CLEASE H)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 7	LEU A 224 VAL A 187 LEU A 148 TYR A 220	None	1.00A	4b3qA-5dggA: undetectable	4b3qA-5dggA: 15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWD_C_NVPC901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 8	LEU A 224 VAL A 187 LEU A 148 TYR A 220	None	0.74A	4pwdC-5dggA: undetectable	4pwdC-5dggA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U9U_A_ACTA1502_0 (NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 5	ARG A 185 GLY A 213 ALA A 214 GLY A 210	None	0.78A	4u9uA-5dggA: undetectable	4u9uA-5dggA: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U9U_B_ACTB1502_0 (NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F)	5dgg	UNCHARACTERIZED PROTEIN (Legionella pneumophila)	4 / 5	ARG A 185 GLY A 213 ALA A 214 GLY A 210	None	0.74A	4u9uB-5dggA: undetectable	4u9uB-5dggA: 22.48

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1D4F_A_ADNA601_2","S-ADENOSYLHOMOCYSTEINE HYDROLASE","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"THR A 281;GLU A 299;THR A 300;HIS A 261","None","1.07A","1d4fA-5dggA:undetectable","1d4fA-5dggA:17.28"],["1GTI_C_CCSC47_0","GLUTATHIONE S-TRANSFERASE","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"THR A 240;GLY A 186;LYS A 263;TYR A 259","None","1.18A","1gtiC-5dggA:undetectable","1gtiC-5dggA:25.00"],["1S1X_A_NVPA999_1","REVERSE TRANSCRIPTASE","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"LEU A 224;VAL A 187;LEU A 148;TYR A 220","None","0.84A","1s1xA-5dggA:undetectable","1s1xA-5dggA:16.32"],["3V81_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"LEU A 224;VAL A 187;LEU A 148;TYR A 220","None","0.74A","3v81C-5dggA:undetectable","3v81C-5dggA:14.29"],["4B3Q_A_NVPA999_1","REVERSE TRANSCRIPTASE\/RIBONUCLEASE H","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"LEU A 224;VAL A 187;LEU A 148;TYR A 220","None","1.00A","4b3qA-5dggA:undetectable","4b3qA-5dggA:15.27"],["4PWD_C_NVPC901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"LEU A 224;VAL A 187;LEU A 148;TYR A 220","None","0.74A","4pwdC-5dggA:undetectable","4pwdC-5dggA:14.29"],["4U9U_A_ACTA1502_0","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"ARG A 185;GLY A 213;ALA A 214;GLY A 210","None","0.78A","4u9uA-5dggA:undetectable","4u9uA-5dggA:22.48"],["4U9U_B_ACTB1502_0","NA(+)-TRANSLOCATING NADH-QUINONE REDUCTASE SUBUNIT F","5dgg","UNCHARACTERIZED PROTEIN","Legionella pneumophila",4,"ARG A 185;GLY A 213;ALA A 214;GLY A 210","None","0.74A","4u9uB-5dggA:undetectable","4u9uB-5dggA:22.48"]]