SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dgk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 VAL A 348
VAL A 224
TRP A 163
 None
 0.97A 1w5uA-5dgkA:
undetectable
1w5uB-5dgkA:
undetectable		 1w5uA-5dgkA:
5.02
1w5uB-5dgkA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 VAL A 224
TRP A 163
VAL A 348
 None
 0.91A 2izqC-5dgkA:
undetectable
2izqD-5dgkA:
undetectable		 2izqC-5dgkA:
5.02
2izqD-5dgkA:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 ILE A 486
ILE A 445
VAL A 452
PHE A 459
ILE A 482
 None
 1.07A 3b2rA-5dgkA:
undetectable		 3b2rA-5dgkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 ASN A 496
HIS A 498
VAL A 447
 None
 0.87A 3elzB-5dgkA:
undetectable		 3elzB-5dgkA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 PHE A 541
TYR A 472
LEU A 517
 None
 0.79A 3keeB-5dgkA:
undetectable		 3keeB-5dgkA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 ALA A 227
VAL A 355
TRP A 163
 None
 0.78A 3l8lC-5dgkA:
undetectable
3l8lD-5dgkA:
undetectable		 3l8lC-5dgkA:
5.02
3l8lD-5dgkA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 LEU A 119
TYR A 125
ALA A 360
GLY A 117
LEU A 129
 None
 1.34A 3ou6D-5dgkA:
undetectable		 3ou6D-5dgkA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 ASP A 321
GLU A 388
SER A 317
 None
 0.81A 3p2kA-5dgkA:
undetectable		 3p2kA-5dgkA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 11 ILE A 127
GLY A 257
ALA A 187
THR A 190
VAL A 402
 None
 1.08A 3rukD-5dgkA:
undetectable		 3rukD-5dgkA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 ILE A 204
ALA A 187
ILE A 306
PHE A 206
THR A 303
 None
 1.18A 4cd2A-5dgkA:
undetectable		 4cd2A-5dgkA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		4 / 6 PHE A 208
ALA A 219
GLY A 184
VAL A 181
 None
 0.94A 4dubA-5dgkA:
undetectable		 4dubA-5dgkA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 GLN A 101
THR A  74
THR A  75
 None
 0.71A 4fu9A-5dgkA:
undetectable		 4fu9A-5dgkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		3 / 3 GLN A 101
THR A  74
THR A  75
 None
 0.74A 4fufA-5dgkA:
undetectable		 4fufA-5dgkA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 VAL A 261
SER A 225
GLY A 184
ASP A 263
THR A 308
 None
None
None
MG  A 702 ( 3.9A)
None
 1.37A 4mm4A-5dgkA:
undetectable		 4mm4A-5dgkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 10 VAL A 261
SER A 225
GLY A 184
ASP A 263
THR A 308
 None
None
None
MG  A 702 ( 3.9A)
None
 1.31A 4mm7A-5dgkA:
undetectable		 4mm7A-5dgkA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		4 / 7 PHE A 334
ILE A 330
TYR A 426
PHE A 183
 None
 1.43A 4o7gA-5dgkA:
undetectable
4o7gB-5dgkA:
undetectable		 4o7gA-5dgkA:
18.25
4o7gB-5dgkA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 GLY A 117
GLY A 115
ILE A 258
LEU A 188
LEU A 126
 None
 1.02A 4qdjA-5dgkA:
undetectable		 4qdjA-5dgkA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		4 / 7 THR A 214
THR A 218
ALA A 221
THR A 308
 ANP  A 701 (-4.5A)
ANP  A 701 (-3.5A)
None
None
 0.99A 4qw0K-5dgkA:
undetectable		 4qw0K-5dgkA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		4 / 7 THR A 214
THR A 218
ALA A 221
THR A 308
 ANP  A 701 (-4.5A)
ANP  A 701 (-3.5A)
None
None
 0.98A 4qw0Y-5dgkA:
undetectable		 4qw0Y-5dgkA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 TYR A 278
LEU A 440
LEU A 323
LEU A 277
ALA A 281
 None
 1.43A 4rtbA-5dgkA:
undetectable		 4rtbA-5dgkA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA611_0
(SERUM ALBUMIN)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		4 / 4 LYS A 513
SER A 439
LEU A 440
ALA A 441
 None
 0.80A 5dbyA-5dgkA:
1.8		 5dbyA-5dgkA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 GLY A 215
ASN A 340
VAL A 171
ALA A 221
LEU A 222
 ANP  A 701 (-3.2A)
None
None
None
None
 1.08A 5kocA-5dgkA:
undetectable		 5kocA-5dgkA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 9 ILE A 445
ALA A 444
ILE A 448
ILE A 516
LEU A 544
 None
 1.01A 5mvmA-5dgkA:
undetectable
5mvmE-5dgkA:
2.5		 5mvmA-5dgkA:
10.28
5mvmE-5dgkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 10 ILE A 516
LEU A 544
ILE A 445
ALA A 444
ILE A 448
 None
 1.02A 5mvmD-5dgkA:
undetectable
5mvmE-5dgkA:
2.5		 5mvmD-5dgkA:
10.28
5mvmE-5dgkA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 VAL A 359
THR A 303
VAL A 305
SER A 307
VAL A 226
 None
 1.50A 6h7lA-5dgkA:
undetectable		 6h7lA-5dgkA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 5dgk ACTIVE HELICASE
(Staphylococcus
aureus) 		5 / 12 VAL A 359
THR A 303
VAL A 305
SER A 307
VAL A 226
 None
 1.50A 6h7lB-5dgkA:
undetectable		 6h7lB-5dgkA:
9.52