SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dgo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 8 ARG A 255
ASN A 261
ASN A 214
ASP A 266
 None
 1.32A 1rs7B-5dgoA:
undetectable		 1rs7B-5dgoA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 564
LEU A 561
LEU A 558
MET A 537
LEU A 549
 SO4  A 607 ( 4.9A)
None
None
None
None
 0.61A 1s9pC-5dgoA:
undetectable		 1s9pC-5dgoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 564
LEU A 561
LEU A 558
MET A 537
VAL A 506
 SO4  A 607 ( 4.9A)
None
None
None
None
 0.88A 1s9pC-5dgoA:
undetectable		 1s9pC-5dgoA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 8 THR A 225
TYR A 238
LEU A 245
MET A 200
 None
EDO  A 606 (-4.3A)
None
None
 1.47A 1uw6G-5dgoA:
undetectable
1uw6H-5dgoA:
undetectable		 1uw6G-5dgoA:
17.34
1uw6H-5dgoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 8 THR A 225
TYR A 238
LEU A 245
MET A 200
 None
EDO  A 606 (-4.3A)
None
None
 1.44A 1uw6P-5dgoA:
undetectable
1uw6Q-5dgoA:
undetectable		 1uw6P-5dgoA:
17.34
1uw6Q-5dgoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 7 ARG A 536
GLU A 531
LYS A 556
ALA A 560
 None
 1.26A 2ejgA-5dgoA:
4.2		 2ejgA-5dgoA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 ASN A  76
GLY A 223
ASP A 226
ILE A 233
THR A 100
 None
 1.33A 2f9wA-5dgoA:
undetectable
2f9wB-5dgoA:
undetectable		 2f9wA-5dgoA:
17.64
2f9wB-5dgoA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 9 VAL A 229
THR A 225
VAL A 376
ASP A 375
VAL A 377
 EDO  A 602 ( 4.9A)
None
EDO  A 601 (-3.6A)
None
None
 1.35A 2l8mA-5dgoA:
undetectable		 2l8mA-5dgoA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 8 LYS A 232
HIS A 101
ASP A 543
ALA A  29
 None
 1.36A 2rk8A-5dgoA:
2.4		 2rk8A-5dgoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 7 ALA A  32
LEU A  36
PHE A   6
PHE A  10
 None
 0.84A 2vcvL-5dgoA:
1.4		 2vcvL-5dgoA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 ASN A  76
GLY A 223
ASP A 226
ILE A 233
THR A 100
 None
 1.29A 3bexC-5dgoA:
undetectable
3bexD-5dgoA:
undetectable		 3bexC-5dgoA:
16.79
3bexD-5dgoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 THR A 100
ASN A  76
GLY A 223
ASP A 226
ILE A 233
 None
 1.30A 3bexE-5dgoA:
undetectable
3bexF-5dgoA:
undetectable		 3bexE-5dgoA:
16.79
3bexF-5dgoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 ASN A  76
GLY A 223
ASP A 226
ILE A 233
THR A 100
 None
 1.30A 3bf1A-5dgoA:
undetectable
3bf1B-5dgoA:
undetectable		 3bf1A-5dgoA:
16.79
3bf1B-5dgoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 ASN A  76
GLY A 223
ASP A 226
ILE A 233
THR A 100
 None
 1.24A 3bf1C-5dgoA:
undetectable
3bf1D-5dgoA:
undetectable		 3bf1C-5dgoA:
16.79
3bf1D-5dgoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 THR A 100
ASN A  76
GLY A 223
ASP A 226
ILE A 233
 None
 1.31A 3bf1C-5dgoA:
undetectable
3bf1D-5dgoA:
undetectable		 3bf1C-5dgoA:
16.79
3bf1D-5dgoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_E_PAUE248_0
(TYPE III
PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 ASN A  76
GLY A 223
ASP A 226
ILE A 233
THR A 100
 None
 1.30A 3bf1E-5dgoA:
undetectable
3bf1F-5dgoA:
undetectable		 3bf1E-5dgoA:
16.79
3bf1F-5dgoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 11 THR A 100
ASN A  76
GLY A 223
ASP A 226
ILE A 233
 None
 1.30A 3bf1E-5dgoA:
undetectable
3bf1F-5dgoA:
undetectable		 3bf1E-5dgoA:
16.79
3bf1F-5dgoA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A  74
GLY A  78
LEU A 117
LEU A  83
LEU A  87
 None
 1.03A 3cjtC-5dgoA:
4.0		 3cjtC-5dgoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A  74
GLY A  78
LEU A 117
LEU A  83
LEU A  87
 None
 1.04A 3cjtG-5dgoA:
4.0		 3cjtG-5dgoA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		3 / 3 ARG A 406
THR A 360
THR A 380
 None
EDO  A 602 ( 4.7A)
None
 0.61A 3k2hB-5dgoA:
undetectable		 3k2hB-5dgoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 10 VAL A 107
ASP A  85
LEU A 185
ARG A 181
VAL A 106
 None
 1.46A 4eilB-5dgoA:
undetectable		 4eilB-5dgoA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 12 GLY A 223
GLN A 227
ALA A 199
LEU A 245
ILE A 233
 None
 1.14A 4pd5A-5dgoA:
1.0		 4pd5A-5dgoA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 5 HIS A 541
ASP A  99
ASP A 123
TYR A 193
 None
 1.37A 4qdjA-5dgoA:
2.7		 4qdjA-5dgoA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		3 / 3 THR A 225
HIS A 369
LEU A 412
 None
None
EDO  A 601 ( 4.2A)
 0.79A 5axdA-5dgoA:
3.0		 5axdA-5dgoA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 10 LEU A 565
PHE A 445
ALA A 529
VAL A 492
PRO A 511
 None
 1.37A 5m0oA-5dgoA:
undetectable		 5m0oA-5dgoA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		5 / 7 LEU A 311
PHE A 300
SER A 304
ILE A 430
ASN A 292
 None
 1.48A 5n5dA-5dgoA:
undetectable		 5n5dA-5dgoA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 8 ASP A 543
HIS A 101
HIS A 194
HIS A 541
 None
 0.99A 5nekB-5dgoA:
undetectable		 5nekB-5dgoA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 6 ASP A 543
HIS A 101
HIS A 194
HIS A 541
 None
 0.90A 5nelA-5dgoA:
undetectable
5nelD-5dgoA:
undetectable		 5nelA-5dgoA:
17.89
5nelD-5dgoA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 6 ARG A 251
HIS A 252
LEU A 213
SER A 210
 None
 1.24A 5syjA-5dgoA:
2.7		 5syjA-5dgoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 6 ARG A 251
HIS A 252
LEU A 213
SER A 210
 None
 1.25A 5syjB-5dgoA:
2.7		 5syjB-5dgoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		3 / 3 GLU A 388
HIS A 396
ARG A 462
 None
None
EDO  A 605 (-3.7A)
 0.99A 5uunA-5dgoA:
undetectable		 5uunA-5dgoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		3 / 3 ARG A 255
PHE A 203
ARG A 251
 None
 1.03A 5y9yA-5dgoA:
undetectable		 5y9yA-5dgoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_G_6ELG501_0
(PROTEIN CEREBLON)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 8 HIS A 541
TRP A  55
HIS A 194
THR A 100
 None
 1.28A 5yj1G-5dgoA:
undetectable
5yj1Y-5dgoA:
undetectable		 5yj1G-5dgoA:
12.23
5yj1Y-5dgoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens) 		4 / 5 ILE A 221
PHE A 361
ARG A 247
THR A 240
 None
 1.30A 5z84N-5dgoA:
undetectable
5z84W-5dgoA:
undetectable		 5z84N-5dgoA:
20.69
5z84W-5dgoA:
7.06