SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dgt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		3 / 3 MET A  79
LEU A  82
SER A  83
 None
 0.59A 1ee2A-5dgtA:
undetectable		 1ee2A-5dgtA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 7 THR A 379
GLY A 427
THR A 523
ILE A 452
 TZD  A 605 ( 4.7A)
TZD  A 605 (-3.2A)
None
None
 0.99A 1gtnJ-5dgtA:
undetectable
1gtnK-5dgtA:
undetectable		 1gtnJ-5dgtA:
11.31
1gtnK-5dgtA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 TYR A 458
ILE A 435
GLY A 427
ALA A 460
GLY A 404
 TZD  A 605 (-3.0A)
None
TZD  A 605 (-3.2A)
TZD  A 605 (-3.3A)
None
 1.20A 1kiaB-5dgtA:
2.9		 1kiaB-5dgtA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		3 / 3 ALA A  96
VAL A 158
TRP A 163
 None
 0.83A 1kqeA-5dgtA:
undetectable
1kqeE-5dgtA:
undetectable		 1kqeA-5dgtA:
2.38
1kqeE-5dgtA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		3 / 3 ALA A  96
VAL A 158
TRP A 163
 None
 0.85A 1kqeB-5dgtA:
undetectable
1kqeD-5dgtA:
undetectable		 1kqeB-5dgtA:
2.38
1kqeD-5dgtA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		3 / 3 TRP A 163
ALA A  96
VAL A 158
 None
 0.85A 1kqeB-5dgtA:
undetectable
1kqeD-5dgtA:
undetectable		 1kqeB-5dgtA:
2.38
1kqeD-5dgtA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		3 / 3 TRP A 163
ALA A  96
VAL A 158
 None
 0.85A 1kqeA-5dgtA:
undetectable
1kqeE-5dgtA:
undetectable		 1kqeA-5dgtA:
2.38
1kqeE-5dgtA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 8 PHE A 405
SER A  88
SER A  83
ALA A 399
 None
 1.15A 1pnlA-5dgtA:
undetectable
1pnlB-5dgtA:
undetectable		 1pnlA-5dgtA:
16.87
1pnlB-5dgtA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 11 LEU A 227
ALA A 200
VAL A 329
LEU A 193
HIS A 267
 None
 1.47A 1qabE-5dgtA:
undetectable		 1qabE-5dgtA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		3 / 3 ARG A 250
SER A 394
TYR A 395
 None
 0.76A 1x70A-5dgtA:
undetectable		 1x70A-5dgtA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 GLY A 274
GLY A 208
PRO A 241
ASP A 219
SER A 297
 None
 1.21A 1xdsA-5dgtA:
undetectable		 1xdsA-5dgtA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 11 TYR A  41
VAL A  51
GLY A  52
ALA A  78
LEU A  69
 None
 1.19A 2bxgA-5dgtA:
undetectable		 2bxgA-5dgtA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_B_NCAB901_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 5 ILE A 446
PRO A 447
PHE A 450
VAL A 422
 None
 1.49A 2hjhB-5dgtA:
5.4		 2hjhB-5dgtA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		3 / 3 ASP A 498
ASN A 499
THR A 357
 None
 0.71A 2pymB-5dgtA:
undetectable		 2pymB-5dgtA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 8 PHE A  35
PHE A  31
GLY A  22
ILE A  53
 None
 0.92A 2qwxA-5dgtA:
2.8
2qwxB-5dgtA:
2.3		 2qwxA-5dgtA:
18.09
2qwxB-5dgtA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 11 THR A 377
ALA A 431
ALA A 460
GLY A 459
THR A 457
 TZD  A 605 (-2.8A)
None
TZD  A 605 (-3.3A)
TZD  A 605 (-3.4A)
None
 1.09A 3mg0V-5dgtA:
undetectable
3mg0W-5dgtA:
undetectable		 3mg0V-5dgtA:
19.61
3mg0W-5dgtA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 6 VAL A 298
VAL A 211
ILE A 205
ARG A 184
 None
 0.99A 3pyyA-5dgtA:
undetectable		 3pyyA-5dgtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 GLY A  97
ALA A  96
ASN A  68
TYR A  41
PHE A  35
 None
 1.45A 3s8pA-5dgtA:
undetectable		 3s8pA-5dgtA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 GLY A  97
ALA A  96
ASN A  68
TYR A  41
PHE A  35
 None
 1.46A 4bupA-5dgtA:
undetectable		 4bupA-5dgtA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		6 / 12 LEU A 373
LEU A 407
ALA A 441
ILE A  53
ALA A 437
ILE A 446
 None
 1.27A 4o2bD-5dgtA:
2.5		 4o2bD-5dgtA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 8 PHE A  35
PHE A  31
GLY A  22
ILE A  53
 None
 0.96A 4qogA-5dgtA:
3.9
4qogB-5dgtA:
2.5		 4qogA-5dgtA:
18.09
4qogB-5dgtA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 8 PHE A  35
PHE A  31
GLY A  22
ILE A  53
 None
 0.95A 4qoiA-5dgtA:
undetectable
4qoiB-5dgtA:
4.0		 4qoiA-5dgtA:
18.09
4qoiB-5dgtA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 5 VAL A 106
TYR A 155
ILE A  93
PRO A 159
 None
 1.20A 4ze1A-5dgtA:
undetectable		 4ze1A-5dgtA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 LEU A 373
LEU A 407
ALA A 441
ALA A 437
ILE A 446
 None
 1.13A 5eypB-5dgtA:
2.4		 5eypB-5dgtA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		4 / 5 SER A 180
SER A 181
SER A 182
SER A 147
 None
 1.01A 5hswA-5dgtA:
undetectable		 5hswA-5dgtA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 VAL A 211
ASP A 210
LEU A 197
LEU A 223
ALA A 322
 None
 1.28A 5nd3B-5dgtA:
2.4		 5nd3B-5dgtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 VAL A 211
ASP A 210
LEU A 197
LEU A 223
ALA A 322
 None
 1.20A 5nd7B-5dgtA:
undetectable		 5nd7B-5dgtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		6 / 12 LEU A 373
LEU A 407
ALA A 441
ILE A  53
ALA A 437
ILE A 446
 None
 1.28A 5xiwB-5dgtA:
undetectable		 5xiwB-5dgtA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 12 LEU A 373
LEU A 407
ALA A 441
ALA A 437
ILE A 446
 None
 1.11A 5xiwD-5dgtA:
2.4		 5xiwD-5dgtA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 9 ALA A 431
ILE A 426
PHE A 405
GLY A 402
GLY A 429
 None
None
None
TZD  A 605 ( 3.8A)
TZD  A 605 (-3.4A)
 1.35A 6awoA-5dgtA:
undetectable		 6awoA-5dgtA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 9 ALA A 431
ILE A 426
PHE A 405
GLY A 402
GLY A 429
 None
None
None
TZD  A 605 ( 3.8A)
TZD  A 605 (-3.4A)
 1.35A 6awqA-5dgtA:
undetectable		 6awqA-5dgtA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5dgt BENZOYLFORMATE
DECARBOXYLASE
(Pseudomonas
putida) 		5 / 11 THR A 377
ALA A 431
ALA A 460
GLY A 459
THR A 457
 TZD  A 605 (-2.8A)
None
TZD  A 605 (-3.3A)
TZD  A 605 (-3.4A)
None
 1.08A 6hwdV-5dgtA:
undetectable		 6hwdV-5dgtA:
12.27