SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dgx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		5 / 12 LEU A 530
PHE A 532
ILE A 519
LEU A 551
THR A 414
 None
 1.23A 1ddrB-5dgxA:
undetectable		 1ddrB-5dgxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		5 / 12 LEU A 530
PHE A 532
ILE A 519
LEU A 551
THR A 414
 None
 1.18A 1jolA-5dgxA:
undetectable		 1jolA-5dgxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		5 / 11 LEU A 530
PHE A 532
ILE A 519
LEU A 551
THR A 414
 None
 1.26A 1jomA-5dgxA:
undetectable		 1jomA-5dgxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		4 / 7 SER A 445
HIS A 446
THR A 439
LEU A 438
 None
 1.11A 3arrA-5dgxA:
undetectable		 3arrA-5dgxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		5 / 12 LEU A 530
PHE A 532
ILE A 519
LEU A 551
THR A 414
 None
 1.19A 3hj3A-5dgxA:
undetectable		 3hj3A-5dgxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		4 / 6 LEU A 387
SER A 378
PHE A 379
ILE A 416
 None
 0.86A 3ko0B-5dgxA:
undetectable		 3ko0B-5dgxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		5 / 11 VAL A 372
LEU A 430
HIS A 446
LEU A 447
ALA A 527
 None
 1.14A 4p65B-5dgxA:
undetectable
4p65D-5dgxA:
undetectable
4p65G-5dgxA:
undetectable
4p65H-5dgxA:
undetectable		 4p65B-5dgxA:
10.34
4p65D-5dgxA:
10.34
4p65G-5dgxA:
15.79
4p65H-5dgxA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		5 / 11 LEU A 530
PHE A 532
ILE A 519
LEU A 551
THR A 414
 None
 1.17A 4qlfA-5dgxA:
undetectable		 4qlfA-5dgxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		5 / 12 LEU A 530
PHE A 532
ILE A 519
LEU A 551
THR A 414
 None
 1.11A 4rgcA-5dgxA:
undetectable		 4rgcA-5dgxA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5dgx LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA
(Francisella
tularensis) 		4 / 7 ARG A 436
GLU A 437
ASP A 434
GLU A 427
 None
 1.34A 6mn5E-5dgxA:
undetectable		 6mn5E-5dgxA:
26.95