SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dh2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 12 LEU A 358
VAL A 350
ILE A 262
LEU A 351
GLU A 226
None
1.25A 2gj5A-5dh2A:
undetectable
2gj5A-5dh2A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
4 / 6 ILE A 118
PRO A 156
LEU A 178
ILE A 159
None
0.94A 2q83B-5dh2A:
undetectable
2q83B-5dh2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
3 / 3 GLU A 101
GLY A 103
THR A 104
None
0.53A 3iazA-5dh2A:
undetectable
3iazA-5dh2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 12 THR A 200
ALA A 347
ILE A 349
ASP A 352
LEU A 351
None
1.07A 3lcvB-5dh2A:
undetectable
3lcvB-5dh2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 9 ASP A 177
ILE A 174
ILE A 160
VAL A 139
ILE A 151
None
1.09A 3nuoA-5dh2A:
undetectable
3nuoA-5dh2A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 12 LEU A 203
ARG A 205
GLY A 103
THR A 104
LEU A 201
None
1.29A 3okxB-5dh2A:
undetectable
3okxB-5dh2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
4 / 7 GLU A 101
ILE A 118
PHE A 102
TYR A 125
None
1.07A 4a97D-5dh2A:
undetectable
4a97D-5dh2A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 9 ILE A 262
GLY A 260
VAL A 224
THR A 265
GLY A 267
None
1.36A 4acaB-5dh2A:
4.9
4acaC-5dh2A:
4.7
4acaB-5dh2A:
21.06
4acaC-5dh2A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
3 / 3 TYR A 171
ARG A 164
SER A 167
None
1.03A 4khpI-5dh2A:
undetectable
4khpJ-5dh2A:
undetectable
4khpI-5dh2A:
16.56
4khpJ-5dh2A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 9 LEU A 361
GLY A 331
ALA A 330
ILE A 299
THR A 238
None
0.99A 4njtD-5dh2A:
undetectable
4njtD-5dh2A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_B_GLYB404_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
4 / 4 GLN A 274
ALA A 241
GLN A 270
THR A 239
None
1.36A 5hhjB-5dh2A:
undetectable
5hhjB-5dh2A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 9 ASP A 177
ILE A 174
ILE A 160
VAL A 139
ILE A 151
None
1.13A 5kr0A-5dh2A:
undetectable
5kr0A-5dh2A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca)
5 / 10 ASP A 177
ILE A 174
ILE A 160
VAL A 139
ILE A 151
None
0.92A 5kr1A-5dh2A:
undetectable
5kr1A-5dh2A:
17.24