SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dhg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU A 322
GLU A 324
ALA A 320
LEU A 318
 None
 1.04A 1eta1-5dhgA:
undetectable		 1eta1-5dhgA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 5 LEU A 322
GLU A 324
ALA A 320
LEU A 318
 None
 1.08A 1eta2-5dhgA:
undetectable		 1eta2-5dhgA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 6 LEU A 322
GLU A 324
ALA A 320
LEU A 318
 None
 1.03A 1etb1-5dhgA:
undetectable		 1etb1-5dhgA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 8 LEU A 322
GLU A 324
ALA A 320
LEU A 318
 None
 0.96A 1sn5C-5dhgA:
undetectable		 1sn5C-5dhgA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE A 231
LEU A 264
LEU A 266
ASP A 323
ILE A  90
 None
 1.19A 1zq9A-5dhgA:
undetectable		 1zq9A-5dhgA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5dhg SOLUBLE CYTOCHROME
B562,NOCICEPTIN
RECEPTOR
(Escherichia
coli;
Homo
sapiens) 		4 / 4 ILE A  76
ARG A 162
ILE A  88
THR A  80
 None
 1.18A 3ia4C-5dhgA:
undetectable		 3ia4C-5dhgA:
16.90