SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dhm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 11 VAL C 222
LEU C  69
LEU C 137
LEU C  66
LEU C  68
 None
 1.42A 1mx1B-5dhmC:
undetectable		 1mx1B-5dhmC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 12 THR C  87
LEU C  68
VAL C 116
VAL C 100
ALA C 118
 None
 0.94A 1q23H-5dhmC:
undetectable
1q23I-5dhmC:
undetectable		 1q23H-5dhmC:
22.30
1q23I-5dhmC:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 12 VAL C 213
ALA C 289
LEU C 315
THR C 279
ILE C 277
 None
 1.08A 1qzfA-5dhmC:
undetectable		 1qzfA-5dhmC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 12 VAL C 213
ALA C 289
LEU C 315
THR C 279
ILE C 277
 None
 1.08A 1qzfB-5dhmC:
undetectable		 1qzfB-5dhmC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 12 VAL C 213
ALA C 289
LEU C 315
THR C 279
ILE C 277
 None
 1.08A 1qzfC-5dhmC:
undetectable		 1qzfC-5dhmC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 12 VAL C 213
ALA C 289
LEU C 315
THR C 279
ILE C 277
 None
 1.09A 1qzfD-5dhmC:
undetectable		 1qzfD-5dhmC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 12 VAL C 213
ALA C 289
LEU C 315
THR C 279
ILE C 277
 None
 1.08A 1qzfE-5dhmC:
undetectable		 1qzfE-5dhmC:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 10 VAL C 100
LEU C 177
VAL C 175
VAL C 116
LEU C  66
 None
 0.82A 3gwxA-5dhmC:
undetectable		 3gwxA-5dhmC:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		5 / 12 VAL C 213
ALA C 289
LEU C 315
THR C 279
ILE C 277
 None
 1.09A 3hj3D-5dhmC:
undetectable		 3hj3D-5dhmC:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		4 / 7 LEU C 266
LEU C 205
SER C 251
ASN C 253
 None
 1.06A 3lm8B-5dhmC:
undetectable
3lm8D-5dhmC:
undetectable		 3lm8B-5dhmC:
21.05
3lm8D-5dhmC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		4 / 8 LEU C 266
LEU C 205
SER C 251
ASN C 253
 None
 1.04A 3lm8B-5dhmC:
undetectable
3lm8D-5dhmC:
undetectable		 3lm8B-5dhmC:
21.05
3lm8D-5dhmC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		4 / 4 ALA C 123
VAL C 124
ASP C 121
LEU C 157
 None
 1.47A 4e7gA-5dhmC:
undetectable		 4e7gA-5dhmC:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		4 / 7 ALA C 153
GLY C 261
ALA C 260
SER C  57
 None
 0.76A 4r1zB-5dhmC:
undetectable		 4r1zB-5dhmC:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 5dhm IMMUNOREACTIVE 32
KDA ANTIGEN
(Porphyromonas
gingivalis) 		3 / 3 LEU C 312
ARG C 314
ARG C 211
 None
 0.75A 4yiaB-5dhmC:
undetectable		 4yiaB-5dhmC:
6.74