SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 7 TYR B 155
VAL B 124
TYR B 146
GLY B 121
 None
 0.95A 11gsA-5disB:
undetectable		 11gsA-5disB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.71A 1a7yA-5disD:
undetectable		 1a7yA-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.71A 1a7yB-5disD:
undetectable		 1a7yB-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.87A 1a7yB-5disD:
undetectable		 1a7yB-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AJ6_A_NOVA1_1
(GYRASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ASN D 272
GLU D 278
ILE D 266
ALA D 264
ILE D  59
 None
 1.48A 1aj6A-5disD:
undetectable		 1aj6A-5disD:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.70A 1dscC-5disD:
undetectable		 1dscC-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.70A 1dscC-5disD:
undetectable		 1dscC-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.68A 1fjaC-5disD:
undetectable		 1fjaC-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.68A 1fjaD-5disD:
undetectable		 1fjaD-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dis SNURPORTIN-1
(Homo
sapiens) 		3 / 3 GLN C  16
ILE C 109
HIS C  25
 None
 0.55A 1fm9A-5disC:
undetectable		 1fm9A-5disC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE2_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.73A 1i3wE-5disD:
undetectable		 1i3wE-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_E_DVAE8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.71A 1i3wE-5disD:
undetectable		 1i3wE-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.66A 1i3wF-5disD:
undetectable		 1i3wF-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG2_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.76A 1i3wG-5disD:
undetectable		 1i3wG-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.70A 1i3wG-5disD:
undetectable		 1i3wG-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_H_DVAH8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.69A 1i3wH-5disD:
undetectable		 1i3wH-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.83A 1jnoA-5disB:
undetectable		 1jnoA-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.84A 1jnoB-5disB:
undetectable		 1jnoB-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.91A 1jo3A-5disB:
undetectable		 1jo3A-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.91A 1jo3B-5disB:
undetectable		 1jo3B-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dis SNURPORTIN-1
(Homo
sapiens) 		3 / 3 GLN C  16
ILE C 109
HIS C  25
 None
 0.55A 1k74A-5disC:
undetectable		 1k74A-5disC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1magA-5disB:
undetectable		 1magA-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1magB-5disB:
undetectable		 1magB-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.69A 1mnvD-5disD:
undetectable		 1mnvD-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.58A 1mnvD-5disD:
undetectable		 1mnvD-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.85A 1ng8A-5disB:
undetectable		 1ng8A-5disB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.85A 1ng8B-5disB:
undetectable		 1ng8B-5disB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1nruA-5disB:
undetectable		 1nruA-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ALA B  67
VAL B  16
TRP B 104
 GTP  B 201 ( 4.6A)
None
None
 0.89A 1nruB-5disB:
undetectable		 1nruB-5disB:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OVF_B_DVAB2_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.66A 1ovfB-5disD:
undetectable		 1ovfB-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.68A 1qfiA-5disD:
undetectable		 1qfiA-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ARG B 106
VAL B 101
TRP B 104
 None
 1.26A 1qwcA-5disB:
undetectable		 1qwcA-5disB:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.82A 1unjF-5disD:
undetectable		 1unjF-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.75A 1unjF-5disD:
undetectable		 1unjF-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.71A 1unjL-5disD:
undetectable		 1unjL-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.67A 1unjL-5disD:
undetectable		 1unjL-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.70A 1unjR-5disD:
undetectable		 1unjR-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.67A 1unjR-5disD:
undetectable		 1unjR-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.71A 1unjW-5disD:
undetectable		 1unjW-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX2_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.69A 1unjX-5disD:
undetectable		 1unjX-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.69A 1unjX-5disD:
undetectable		 1unjX-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.74A 1unmE-5disD:
undetectable		 1unmE-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.70A 1unmE-5disD:
undetectable		 1unmE-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.71A 1unmF-5disD:
undetectable		 1unmF-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1944
THR D1946
PRO D1943
 None
 0.70A 1unmF-5disD:
undetectable		 1unmF-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5dis SNURPORTIN-1
(Homo
sapiens) 		5 / 9 GLY C 159
ALA C 134
SER C 154
LEU C 156
LEU C 172
 None
 1.39A 1y7iA-5disC:
undetectable		 1y7iA-5disC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 5dis SNURPORTIN-1
(Homo
sapiens) 		5 / 9 GLY C 159
ALA C 134
SER C 154
LEU C 156
TYR C 183
 None
 1.22A 1y7iA-5disC:
undetectable		 1y7iA-5disC:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		5 / 12 THR B  42
GLY B  22
GLY B  20
GLY B  68
ASP B 125
 MG  B 202 ( 2.9A)
GTP  B 201 (-3.3A)
GTP  B 201 (-3.6A)
GTP  B 201 (-3.8A)
GTP  B 201 (-2.6A)
 1.00A 2b25A-5disB:
undetectable		 2b25A-5disB:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5dis SNURPORTIN-1
(Homo
sapiens) 		4 / 7 ARG C 129
ASP C 187
ASP C 173
TYR C 266
 PRO  C 301 (-4.4A)
None
None
None
 1.11A 2e5dA-5disC:
undetectable
2e5dB-5disC:
undetectable		 2e5dA-5disC:
20.28
2e5dB-5disC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5dis SNURPORTIN-1
(Homo
sapiens) 		4 / 7 ASP C 173
TYR C 266
ARG C 129
ASP C 187
 None
None
PRO  C 301 (-4.4A)
None
 1.12A 2e5dA-5disC:
undetectable
2e5dB-5disC:
undetectable		 2e5dA-5disC:
20.28
2e5dB-5disC:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		4 / 8 GLY D2015
THR D2016
ALA D2017
ALA D2018
 None
 0.59A 2ej3A-5disD:
undetectable		 2ej3A-5disD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR D 193
ALA D 346
ALA D 190
GLY D 191
ALA D 188
 None
 1.19A 2f16H-5disD:
undetectable
2f16I-5disD:
undetectable		 2f16H-5disD:
17.50
2f16I-5disD:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 11 THR D 193
ALA D 346
ALA D 190
GLY D 191
ALA D 188
 None
 1.18A 2f16V-5disD:
undetectable
2f16W-5disD:
undetectable		 2f16V-5disD:
17.50
2f16W-5disD:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 8 TYR B 155
VAL B 124
TYR B 146
GLY B 121
 None
 0.92A 2gssA-5disB:
undetectable		 2gssA-5disB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 8 TYR B 155
VAL B 124
TYR B 146
GLY B 121
 None
 0.93A 2gssB-5disB:
undetectable		 2gssB-5disB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5dis SNURPORTIN-1
(Homo
sapiens) 		3 / 3 SER C 267
TYR C 266
HIS C 265
 None
 0.43A 2r2vD-5disC:
undetectable		 2r2vD-5disC:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 TRP D 230
ALA D 231
THR D 320
GLY D 260
PRO D 257
 None
 1.05A 2ve3B-5disD:
undetectable		 2ve3B-5disD:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5dis SNURPORTIN-1
(Homo
sapiens) 		3 / 3 SER C  13
GLU C 106
ASP C 110
 None
 0.75A 2zulA-5disC:
undetectable		 2zulA-5disC:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.90A 316dC-5disD:
undetectable		 316dC-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE D 108
LEU D 262
ILE D  59
VAL D  23
LEU D  20
 None
 1.11A 3a51C-5disD:
undetectable		 3a51C-5disD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5dis SNURPORTIN-1
(Homo
sapiens) 		3 / 3 SER C  13
GLU C 106
ASP C 110
 None
 0.76A 3dmhA-5disC:
undetectable		 3dmhA-5disC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 7 TYR B 155
VAL B 124
TYR B 146
GLY B 121
 None
 0.92A 3gssA-5disB:
undetectable		 3gssA-5disB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 7 TYR B 155
VAL B 124
TYR B 146
GLY B 121
 None
 0.94A 3gssB-5disB:
undetectable		 3gssB-5disB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 VAL D 343
GLY D 187
ALA D 188
LEU D 192
LEU D 160
 None
 0.99A 3hs6A-5disD:
undetectable		 3hs6A-5disD:
21.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 7 ASN D  12
TRP D  62
GLU D 153
MET D 330
ARG D 344
 None
 0.98A 3jyrA-5disD:
43.5		 3jyrA-5disD:
73.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 8 TYR B 155
VAL B 124
TYR B 146
GLY B 121
 None
 0.93A 3n9jA-5disB:
undetectable		 3n9jA-5disB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)		 5dis SNURPORTIN-1
(Homo
sapiens) 		4 / 6 LEU C 224
SER C 153
ARG C 161
LEU C 155
 None
 1.09A 3rd0A-5disC:
undetectable		 3rd0A-5disC:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE D 156
GLY D 300
LEU D 299
GLU D 111
ASP D  14
 None
 1.28A 3tbgA-5disD:
undetectable		 3tbgA-5disD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		6 / 12 PHE D 156
GLY D 300
LEU D 299
GLU D 111
ALA D 231
ASP D  14
 None
 1.28A 3tbgB-5disD:
undetectable		 3tbgB-5disD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 PHE D 156
GLY D 300
LEU D 299
GLU D 111
ASP D  14
 None
 1.30A 3tbgC-5disD:
undetectable		 3tbgC-5disD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		6 / 12 PHE D 156
GLY D 300
LEU D 299
GLU D 111
ALA D 231
ASP D  14
 None
 1.29A 3tbgD-5disD:
undetectable		 3tbgD-5disD:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_1
(HIV-1 PROTEASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		6 / 11 GLY D 300
ALA D 301
VAL D 259
GLY D 260
THR D  93
PRO D 107
 None
 1.44A 3ufnA-5disD:
undetectable		 3ufnA-5disD:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HIV_D_DVAD2_0
(ACTINOMYCIN D)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		3 / 3 THR D1946
PRO D1943
THR D1944
 None
 0.74A 4hivD-5disD:
undetectable		 4hivD-5disD:
2.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ILE D 266
ALA D 105
LEU D  20
VAL D  23
ILE D  59
 None
 1.05A 4m2xG-5disD:
undetectable		 4m2xG-5disD:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 9 ALA D 264
ALA D 105
LEU D 103
LEU D 262
VAL D 261
 None
 1.15A 4or0B-5disD:
undetectable		 4or0B-5disD:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ALA D 213
ASP D  14
GLY D 228
GLU D 111
 None
 0.91A 5btdA-5disD:
undetectable
5btdB-5disD:
undetectable
5btdC-5disD:
undetectable		 5btdA-5disD:
21.10
5btdB-5disD:
20.21
5btdC-5disD:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ALA D 213
ASP D  14
GLY D 228
GLU D 111
 None
 0.92A 5btdA-5disD:
undetectable
5btdC-5disD:
undetectable
5btdD-5disD:
undetectable		 5btdA-5disD:
21.10
5btdC-5disD:
21.10
5btdD-5disD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		4 / 7 ALA D 213
ASP D  14
GLY D 228
GLU D 111
 None
 0.90A 5btgA-5disD:
undetectable
5btgC-5disD:
undetectable
5btgD-5disD:
undetectable		 5btgA-5disD:
21.10
5btgC-5disD:
21.10
5btgD-5disD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		4 / 5 SER D 238
ARG D 316
GLY D 243
THR D 320
 None
 1.15A 5btiC-5disD:
undetectable
5btiD-5disD:
undetectable		 5btiC-5disD:
21.06
5btiD-5disD:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		3 / 3 ARG B 106
VAL B 101
TRP B 104
 None
 1.25A 5fvoA-5disB:
undetectable		 5fvoA-5disB:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5dis SNURPORTIN-1
(Homo
sapiens) 		4 / 6 VAL C 122
TYR C 260
MET C 208
ASP C 173
 None
 1.05A 5iwuA-5disC:
undetectable		 5iwuA-5disC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 5dis GTP-BINDING NUCLEAR
PROTEIN RAN
(Homo
sapiens) 		4 / 8 LEU B  50
LEU B  15
MET B  89
ILE B  87
 None
 0.98A 5mzjA-5disB:
undetectable		 5mzjA-5disB:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA D 342
ALA D 338
GLY D 166
ALA D 188
VAL D 181
 None
 0.76A 5w4zA-5disD:
undetectable		 5w4zA-5disD:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		5 / 12 ALA D 342
ALA D 338
GLY D 166
ALA D 188
VAL D 181
 None
 0.78A 5w4zB-5disD:
undetectable		 5w4zB-5disD:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5dis SNURPORTIN-1
(Homo
sapiens) 		3 / 3 GLN C  16
ILE C 109
HIS C  25
 None
 0.62A 5z12B-5disC:
undetectable		 5z12B-5disC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA609_0
(ALPHA-AMYLASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLY D 243
TRP D 232
ASP D 236
TYR D 242
 None
 1.48A 6ag0A-5disD:
undetectable		 6ag0A-5disD:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214
(Escherichia
coli;
Homo
sapiens) 		4 / 7 GLY D 243
TRP D 232
ASP D 236
TYR D 242
 None
 1.48A 6ag0C-5disD:
undetectable		 6ag0C-5disD:
11.44