SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5diy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_A_BHSA1610_1
(NITRIC OXIDE
SYNTHASE)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		4 / 8 VAL A  89
ARG A 147
ALA A 140
GLU A 129
 None
 1.11A 1dmiA-5diyA:
undetectable
1dmiB-5diyA:
undetectable		 1dmiA-5diyA:
22.30
1dmiB-5diyA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		3 / 3 ASP A 143
ARG A 147
ASP A 130
 None
 0.88A 1vptA-5diyA:
undetectable		 1vptA-5diyA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		8 / 11 ASP A 119
CYH A 164
TYR A 168
THR A 193
VAL A 197
ASN A 223
ASP A 228
ASN A 257
 None
 0.69A 2w4xA-5diyA:
36.0		 2w4xA-5diyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W4X_A_STZA1591_1
(O-GLCNACASE BT_4395)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		9 / 11 CYH A 164
TYR A 168
THR A 193
VAL A 197
TRP A 221
ASN A 223
VAL A 226
ASP A 228
ASN A 257
 None
 0.43A 2w4xA-5diyA:
36.0		 2w4xA-5diyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		4 / 8 TYR A  90
PHE A 118
VAL A 148
LEU A 145
 None
 0.89A 2w98B-5diyA:
undetectable		 2w98B-5diyA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		8 / 12 ASP A 119
TYR A 168
THR A 193
VAL A 197
ASN A 223
VAL A 226
ASP A 228
ASN A 257
 None
 0.63A 2x0yA-5diyA:
41.7		 2x0yA-5diyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_A_X0TA1625_1
(O-GLCNACASE NAGJ)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		8 / 12 TYR A 168
THR A 193
VAL A 197
TRP A 221
ASN A 223
VAL A 226
ASP A 228
ASN A 257
 None
 0.47A 2x0yA-5diyA:
41.7		 2x0yA-5diyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		7 / 12 ASP A 119
TYR A 168
THR A 193
ASN A 223
VAL A 226
ASP A 228
ASN A 257
 None
 0.56A 2x0yB-5diyA:
42.7		 2x0yB-5diyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		6 / 12 LYS A  43
THR A 193
ASN A 223
VAL A 226
ASP A 228
ASN A 257
 None
 0.81A 2x0yB-5diyA:
42.7		 2x0yB-5diyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0Y_B_X0TB1625_1
(O-GLCNACASE NAGJ)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		7 / 12 TYR A 168
THR A 193
TRP A 221
ASN A 223
VAL A 226
ASP A 228
ASN A 257
 None
 0.43A 2x0yB-5diyA:
42.7		 2x0yB-5diyA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		4 / 7 ILE A 161
THR A 166
THR A  98
ARG A  49
 None
 1.19A 3nxuA-5diyA:
undetectable		 3nxuA-5diyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		4 / 6 ILE A 161
LEU A 145
PHE A 118
GLY A  85
 None
 1.03A 3sj1X-5diyA:
undetectable		 3sj1X-5diyA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		5 / 12 LEU A 145
LEU A 125
LEU A 137
TYR A 176
TYR A  90
 None
 1.15A 3vw7A-5diyA:
3.0		 3vw7A-5diyA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		5 / 12 ILE A 162
GLY A 115
VAL A 121
ASP A 119
LEU A 145
 None
 1.13A 4a81A-5diyA:
undetectable		 4a81A-5diyA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		3 / 3 ASP A 143
ARG A 147
ASP A 130
 None
 0.89A 4fp9D-5diyA:
undetectable		 4fp9D-5diyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		3 / 3 TYR A 224
ARG A 243
HIS A 242
 None
 1.16A 4fubA-5diyA:
undetectable		 4fubA-5diyA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		3 / 3 ASP A 143
ARG A 147
ASP A 130
 None
 0.79A 4fzvA-5diyA:
undetectable		 4fzvA-5diyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		4 / 6 PRO A  42
ILE A  82
TYR A  56
PHE A  80
 None
 1.07A 4g10A-5diyA:
2.3		 4g10A-5diyA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		5 / 12 PHE A 191
ILE A   9
GLY A  12
ALA A  41
ILE A 162
 None
 0.91A 4nkxA-5diyA:
undetectable		 4nkxA-5diyA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		3 / 3 LEU A 381
ASP A 384
TYR A 385
 None
 0.63A 4qc6B-5diyA:
undetectable		 4qc6B-5diyA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		5 / 12 LEU A 107
LEU A 152
PHE A 118
LEU A  99
ILE A 100
 None
 1.13A 4x1fA-5diyA:
undetectable		 4x1fA-5diyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		6 / 12 VAL A 448
SER A 451
THR A 452
PHE A 335
PHE A 397
VAL A 331
 None
 1.46A 6a93B-5diyA:
undetectable		 6a93B-5diyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		6 / 12 VAL A 448
SER A 451
THR A 452
LEU A 347
PHE A 335
PHE A 397
 None
 1.30A 6a94B-5diyA:
undetectable		 6a94B-5diyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		6 / 12 VAL A 448
SER A 451
THR A 452
PHE A 335
PHE A 397
VAL A 331
 None
 1.44A 6a94B-5diyA:
undetectable		 6a94B-5diyA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		4 / 8 ILE A 391
THR A 392
THR A 398
GLU A 410
 None
 0.82A 6c06C-5diyA:
undetectable		 6c06C-5diyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		5 / 11 VAL A 448
SER A 451
THR A 452
LEU A 347
PHE A 397
 None
 1.09A 6dryA-5diyA:
undetectable		 6dryA-5diyA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5diy HYALURONIDASE
(Thermobaculum
terrenum) 		5 / 12 VAL A 448
SER A 451
THR A 452
LEU A 347
PHE A 397
 None
 1.12A 6drzA-5diyA:
4.1		 6drzA-5diyA:
22.15