SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dj4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 10 ILE A 173
ALA A 467
ASN A 163
ILE A 115
ILE A 162
 None
 1.21A 1j3jA-5dj4A:
undetectable		 1j3jA-5dj4A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 5dj4 SESTRIN-2
(Homo
sapiens) 		4 / 4 HIS A 454
VAL A 455
THR A 386
LEU A 416
 LEU  A 501 (-3.8A)
LEU  A 501 ( 4.9A)
LEU  A 501 (-3.0A)
None
 1.10A 1oq5A-5dj4A:
undetectable		 1oq5A-5dj4A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		3 / 3 VAL A  81
ALA A  80
HIS A  97
 None
 0.77A 1q23L-5dj4A:
undetectable		 1q23L-5dj4A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 LEU A 295
ALA A 429
LEU A 459
VAL A 455
LEU A 417
 None
None
None
LEU  A 501 ( 4.9A)
None
 1.29A 1s9pB-5dj4A:
undetectable		 1s9pB-5dj4A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 GLY A 360
GLY A 359
LEU A  96
LEU A  99
LEU A 200
 None
 1.26A 1ya4B-5dj4A:
undetectable		 1ya4B-5dj4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 11 ILE A 173
ALA A 467
ASN A 163
ILE A 115
ILE A 162
 None
 1.26A 2blaA-5dj4A:
undetectable		 2blaA-5dj4A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5dj4 SESTRIN-2
(Homo
sapiens) 		4 / 6 LEU A 194
LEU A 165
HIS A 177
TRP A 189
 None
 1.26A 3bj8C-5dj4A:
undetectable
3bj8D-5dj4A:
undetectable		 3bj8C-5dj4A:
16.84
3bj8D-5dj4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 VAL A 428
SER A 209
LEU A 459
ALA A 120
GLY A 215
 None
 1.06A 3ln1D-5dj4A:
undetectable		 3ln1D-5dj4A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5dj4 SESTRIN-2
(Homo
sapiens) 		4 / 6 LEU A 355
ARG A 477
MET A 479
THR A 480
 None
 1.19A 3wg7A-5dj4A:
undetectable
3wg7J-5dj4A:
undetectable		 3wg7A-5dj4A:
21.04
3wg7J-5dj4A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 LEU A 421
LEU A 417
GLN A 415
MET A 265
VAL A 388
 None
 1.20A 3zqtA-5dj4A:
undetectable		 3zqtA-5dj4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 10 TRP A 145
LEU A 149
GLY A 148
ALA A 467
MET A 464
 None
 1.48A 4fe1A-5dj4A:
1.8
4fe1J-5dj4A:
undetectable		 4fe1A-5dj4A:
21.11
4fe1J-5dj4A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 THR A 476
THR A 202
VAL A 199
ILE A 195
GLU A 358
 None
 1.30A 4i41A-5dj4A:
undetectable		 4i41A-5dj4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 ILE A 216
LEU A 363
TYR A  89
LEU A 207
HIS A 203
 None
 1.25A 4j03A-5dj4A:
undetectable		 4j03A-5dj4A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 11 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.94A 4j6cA-5dj4A:
undetectable		 4j6cA-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 10 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.96A 4j6cB-5dj4A:
undetectable		 4j6cB-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.98A 4j6dA-5dj4A:
undetectable		 4j6dA-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.96A 4j6dB-5dj4A:
undetectable		 4j6dB-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.94A 4jbtA-5dj4A:
undetectable		 4jbtA-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 11 ALA A 116
ALA A 119
ALA A 120
VAL A 211
LEU A  79
 None
 0.93A 4jbtB-5dj4A:
undetectable		 4jbtB-5dj4A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 ASN A 163
SER A 160
GLU A 161
ASP A 325
GLN A 332
 None
 1.37A 4uroA-5dj4A:
undetectable		 4uroA-5dj4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 ASN A 163
SER A 160
GLU A 161
ASP A 325
GLN A 332
 None
 1.31A 4uroB-5dj4A:
undetectable		 4uroB-5dj4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5dj4 SESTRIN-2
(Homo
sapiens) 		4 / 8 PHE A 367
PHE A 401
TRP A 394
TYR A 405
 None
 1.30A 5amkA-5dj4A:
undetectable		 5amkA-5dj4A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5dj4 SESTRIN-2
(Homo
sapiens) 		4 / 6 VAL A 199
HIS A 203
LEU A 200
LEU A  99
 None
 1.07A 5hrqB-5dj4A:
undetectable
5hrqI-5dj4A:
undetectable
5hrqJ-5dj4A:
undetectable		 5hrqB-5dj4A:
4.97
5hrqI-5dj4A:
4.35
5hrqJ-5dj4A:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5dj4 SESTRIN-2
(Homo
sapiens) 		5 / 12 LEU A  79
VAL A  81
LEU A  85
VAL A 453
TYR A 424
 None
 1.43A 5i8fA-5dj4A:
undetectable		 5i8fA-5dj4A:
15.56