SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5djs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JKH_A_EFZA999_1
(HIV-1 RT, A-CHAIN
HIV-1 RT, B-CHAIN)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 11 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.36A 1jkhA-5djsA:
undetectable
1jkhB-5djsA:
undetectable		 1jkhA-5djsA:
19.37
1jkhB-5djsA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 11 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.42A 1lwcA-5djsA:
undetectable		 1lwcA-5djsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 ILE A 342
GLY A 343
VAL A  93
PRO A 418
ALA A 125
 None
 0.88A 1nv8A-5djsA:
3.7		 1nv8A-5djsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 ILE A 342
GLY A 343
VAL A  93
PRO A 418
ALA A 125
 None
 0.88A 1nv8B-5djsA:
2.8		 1nv8B-5djsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 TYR A 297
ASP A 442
HIS A 133
LEU A 137
 None
 1.25A 1pk2A-5djsA:
undetectable		 1pk2A-5djsA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 ILE A 342
GLY A 343
VAL A  93
PRO A 418
ALA A 125
 None
 0.89A 1sg9B-5djsA:
2.9		 1sg9B-5djsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 10 VAL A 346
LEU A 364
LEU A 347
TYR A 468
ILE A 353
 None
 1.44A 1sq5D-5djsA:
undetectable		 1sq5D-5djsA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 ILE A 342
GLY A 343
VAL A  93
PRO A 418
ALA A 125
 None
 0.90A 1vq1B-5djsA:
2.2		 1vq1B-5djsA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 9 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.45A 1vrtA-5djsA:
undetectable		 1vrtA-5djsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 5 LEU A 354
GLY A 474
PRO A 331
ALA A 360
 None
 0.89A 2aohA-5djsA:
undetectable		 2aohA-5djsA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 10 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.40A 2hndA-5djsA:
undetectable		 2hndA-5djsA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 10 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.39A 2hnyA-5djsA:
undetectable		 2hnyA-5djsA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 ASP A 371
LEU A 369
GLY A 368
GLY A  57
LEU A 339
 None
 1.02A 2nxeB-5djsA:
3.9		 2nxeB-5djsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 7 LEU A 417
LEU A 414
ILE A 471
GLN A 465
 None
 1.07A 2qqcA-5djsA:
undetectable
2qqcF-5djsA:
undetectable		 2qqcA-5djsA:
8.65
2qqcF-5djsA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 7 LEU A 417
LEU A 414
ILE A 471
GLN A 465
 None
 1.07A 2qqcG-5djsA:
undetectable
2qqcJ-5djsA:
undetectable		 2qqcG-5djsA:
8.65
2qqcJ-5djsA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		3 / 3 SER A  78
TYR A  81
HIS A  80
 None
 0.76A 2r2vD-5djsA:
undetectable		 2r2vD-5djsA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 ILE A 410
GLY A 334
LEU A 362
LEU A 392
 None
 0.88A 2vctA-5djsA:
undetectable		 2vctA-5djsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 ILE A 410
GLY A 334
LEU A 362
LEU A 392
 None
 0.85A 2vctB-5djsA:
undetectable		 2vctB-5djsA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 11 GLY A 476
GLY A 474
ILE A 353
ALA A 360
THR A 481
 None
 1.25A 2vdvF-5djsA:
4.9		 2vdvF-5djsA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 ALA A  11
ILE A   9
SER A  14
LEU A  13
ARG A  21
 None
 1.25A 3gyqA-5djsA:
3.6
3gyqB-5djsA:
3.7		 3gyqA-5djsA:
20.30
3gyqB-5djsA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 GLU A 466
ARG A 463
VAL A 436
ASP A 470
ILE A 471
 None
 1.43A 3jayA-5djsA:
2.7		 3jayA-5djsA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		3 / 3 ARG A  95
LEU A  87
THR A 374
 None
 0.72A 3oxcA-5djsA:
undetectable		 3oxcA-5djsA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 10 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.45A 3qipA-5djsA:
undetectable		 3qipA-5djsA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_C_D16C301_1
(THYMIDYLATE SYNTHASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 11 SER A 340
LEU A  51
LEU A 100
GLY A  84
TYR A 110
 None
 1.47A 4foxC-5djsA:
undetectable		 4foxC-5djsA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_A_TFPA203_1
(CALMODULIN)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 ILE A 240
LEU A 163
ALA A 519
VAL A 263
 None
 0.70A 4rjdA-5djsA:
undetectable		 4rjdA-5djsA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 6 TRP A 246
ILE A 271
ILE A  97
VAL A  93
 None
 0.89A 4zj8A-5djsA:
14.6		 4zj8A-5djsA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 LEU A 181
LEU A 214
ARG A 190
LEU A 207
 None
 0.83A 5dxeA-5djsA:
undetectable		 5dxeA-5djsA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 5 ALA A 103
TYR A  81
GLY A 445
LEU A 248
 None
 0.99A 5eslA-5djsA:
undetectable		 5eslA-5djsA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		3 / 3 THR A 225
ASP A 226
ALA A 227
 None
 0.00A 5g5gB-5djsA:
undetectable		 5g5gB-5djsA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5J_A_MF8A600_1
(CYTOCHROME P450 3A4)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 4 ARG A 377
SER A  90
ARG A  67
ALA A  63
 None
 0.89A 5g5jA-5djsA:
0.0		 5g5jA-5djsA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 11 LEU A 181
VAL A 242
VAL A 195
GLY A 166
LEU A 268
 None
 1.48A 5hbmA-5djsA:
undetectable		 5hbmA-5djsA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 7 THR A 401
LEU A 404
THR A 406
VAL A 433
 None
 1.13A 5ov9A-5djsA:
undetectable		 5ov9A-5djsA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 THR A 401
LEU A 404
THR A 406
VAL A 433
 None
 1.10A 5ov9B-5djsA:
undetectable		 5ov9B-5djsA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 VAL A 184
VAL A 177
ALA A 444
LEU A 244
LEU A 508
 None
 1.27A 6a7pB-5djsA:
undetectable		 6a7pB-5djsA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 LEU A 181
LEU A 214
ARG A 190
LEU A 207
 None
 0.84A 6cbzA-5djsA:
undetectable		 6cbzA-5djsA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		5 / 12 SER A  78
TYR A 110
ASN A  85
LEU A  87
LEU A  66
 None
 1.43A 6chgC-5djsA:
undetectable		 6chgC-5djsA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN
(Thermobaculum
terrenum) 		4 / 8 VAL A  88
ASN A  82
TYR A  81
GLU A  55
 None
 1.33A 6gneB-5djsA:
18.1		 6gneB-5djsA:
22.00