SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dkk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		5 / 12 ASN A 286
CYH A 287
ASN A 329
ILE A 303
GLN A 350
 FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-4.2A)
FMN  A 401 (-3.8A)
 1.44A 4kukA-5dkkA:
19.4		 4kukA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		9 / 12 VAL A 253
ASN A 262
ASN A 286
ARG A 288
GLN A 291
ASN A 319
ASN A 329
ILE A 333
GLN A 350
 None
FMN  A 401 (-3.7A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
None
FMN  A 401 (-3.8A)
 0.55A 4kukA-5dkkA:
19.4		 4kukA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		9 / 12 VAL A 253
ASN A 262
ASN A 286
CYH A 287
ARG A 288
GLN A 291
ASN A 329
ILE A 333
GLN A 350
 None
FMN  A 401 (-3.7A)
FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.1A)
None
FMN  A 401 (-3.8A)
 0.75A 4kukA-5dkkA:
19.4		 4kukA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		6 / 12 VAL A 253
ASN A 262
ASN A 286
CYH A 287
ASN A 319
ILE A 333
 None
FMN  A 401 (-3.7A)
FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.0A)
None
 1.27A 4kukA-5dkkA:
19.4		 4kukA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		5 / 9 LEU A 290
VAL A 300
ILE A 303
PHE A 346
GLY A 348
 FMN  A 401 (-4.1A)
FMN  A 401 (-4.4A)
FMN  A 401 (-4.2A)
FMN  A 401 (-4.8A)
FMN  A 401 (-3.7A)
 0.53A 4kukA-5dkkA:
19.4		 4kukA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		8 / 12 VAL A 253
ASN A 262
ASN A 286
ARG A 288
GLN A 291
ASN A 319
ASN A 329
GLN A 350
 None
FMN  A 401 (-3.7A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.8A)
 0.69A 4kuoA-5dkkA:
18.5		 4kuoA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		8 / 12 VAL A 253
ASN A 262
ASN A 286
CYH A 287
ARG A 288
GLN A 291
ASN A 329
GLN A 350
 None
FMN  A 401 (-3.7A)
FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.8A)
 0.86A 4kuoA-5dkkA:
18.5		 4kuoA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		5 / 12 VAL A 253
ASN A 262
ASN A 286
CYH A 287
ASN A 319
 None
FMN  A 401 (-3.7A)
FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-3.0A)
 1.30A 4kuoA-5dkkA:
18.5		 4kuoA-5dkkA:
36.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		7 / 12 ARG A 288
GLN A 291
ILE A 307
ASN A 319
ASN A 329
GLY A 348
GLN A 350
 FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.84A 4r38A-5dkkA:
17.7		 4r38A-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		6 / 12 CYH A 287
ARG A 288
GLN A 291
ILE A 307
GLY A 348
GLN A 350
 FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.97A 4r38A-5dkkA:
17.7		 4r38A-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		4 / 8 ASN A 286
LEU A 290
VAL A 300
PHE A 346
 FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-4.4A)
FMN  A 401 (-4.8A)
 0.79A 4r38A-5dkkA:
17.7		 4r38A-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		8 / 12 ASN A 286
ARG A 288
GLN A 291
ILE A 307
ASN A 319
ASN A 329
GLY A 348
GLN A 350
 FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.86A 4r38B-5dkkA:
17.5		 4r38B-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		7 / 12 ASN A 286
CYH A 287
ARG A 288
GLN A 291
ILE A 307
GLY A 348
GLN A 350
 FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.96A 4r38B-5dkkA:
17.5		 4r38B-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		6 / 12 ASN A 286
CYH A 287
ARG A 288
ILE A 307
ASN A 319
GLY A 348
 FMN  A 401 (-3.0A)
FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-3.7A)
 1.29A 4r38B-5dkkA:
17.5		 4r38B-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		7 / 12 ARG A 288
GLN A 291
ILE A 307
ASN A 319
ASN A 329
GLY A 348
GLN A 350
 FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.86A 4r38C-5dkkA:
17.6		 4r38C-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		6 / 12 CYH A 287
ARG A 288
GLN A 291
ILE A 307
GLY A 348
GLN A 350
 FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.99A 4r38C-5dkkA:
17.6		 4r38C-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		7 / 12 ARG A 288
GLN A 291
ILE A 307
ASN A 319
ASN A 329
GLY A 348
GLN A 350
 FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.87A 4r38D-5dkkA:
17.7		 4r38D-5dkkA:
35.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		6 / 12 CYH A 287
ARG A 288
GLN A 291
ILE A 307
GLY A 348
GLN A 350
 FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 1.02A 4r38D-5dkkA:
17.7		 4r38D-5dkkA:
35.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		7 / 12 CYH A 287
ARG A 288
GLN A 291
ILE A 307
ASN A 319
ASN A 329
GLN A 350
 FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-2.8A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.8A)
 0.87A 4r3aA-5dkkA:
14.4		 4r3aA-5dkkA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		7 / 12 CYH A 287
ARG A 288
ILE A 307
ASN A 319
ASN A 329
GLY A 348
GLN A 350
 FMN  A 401 (-3.4A)
FMN  A 401 (-4.1A)
FMN  A 401 (-4.6A)
FMN  A 401 (-3.0A)
FMN  A 401 (-4.1A)
FMN  A 401 (-3.7A)
FMN  A 401 (-3.8A)
 0.83A 4r3aB-5dkkA:
14.4		 4r3aB-5dkkA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 5dkk LOV DOMAIN
(Phaeodactylum
tricornutum) 		4 / 6 SER A 278
LEU A 279
ASP A 280
LEU A 272
 None
 0.85A 4wozA-5dkkA:
undetectable
4wozB-5dkkA:
undetectable		 4wozA-5dkkA:
19.73
4wozB-5dkkA:
19.73