SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5dkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Neisseria
meningitidis) 		5 / 12 ARG A 123
ILE A  68
LEU A 108
ALA A 101
ALA A 100
 None
 0.93A 2oc8A-5dkpA:
undetectable		 2oc8A-5dkpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Neisseria
meningitidis) 		5 / 12 GLY A  78
SER A  44
PRO A  39
GLY A  72
ASN A  46
 None
 1.47A 3r24A-5dkpA:
undetectable		 3r24A-5dkpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Neisseria
meningitidis) 		3 / 3 ARG A  27
LYS A  30
ARG A  20
 None
 1.39A 3w1wA-5dkpA:
undetectable
3w1wB-5dkpA:
undetectable		 3w1wA-5dkpA:
20.74
3w1wB-5dkpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Neisseria
meningitidis) 		3 / 3 ARG A  20
ARG A  27
LYS A  30
 None
 1.36A 3w1wA-5dkpA:
undetectable
3w1wB-5dkpA:
undetectable		 3w1wA-5dkpA:
20.74
3w1wB-5dkpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Neisseria
meningitidis) 		5 / 12 LEU A 107
LEU A 108
ILE A 126
LEU A 191
HIS A 127
 None
 1.21A 5toaB-5dkpA:
undetectable		 5toaB-5dkpA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Neisseria
meningitidis) 		3 / 3 GLU A 185
TYR A 189
ARG A 166
 None
 0.86A 5uunA-5dkpA:
undetectable		 5uunA-5dkpA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5dkp ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT
(Neisseria
meningitidis) 		3 / 3 GLU A 185
TYR A 189
ARG A 166
 None
 0.84A 5uunB-5dkpA:
undetectable		 5uunB-5dkpA:
25.85